Design, synthesis and pharmacological evaluation of novel tetrasubstituted thiophene analogues as anti-inflammatory agents

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 23, Issue 6, 2008, Pages 819-828

  Molvi, Khurshid I ^a   Sudarsanam, Vasudevan ^b   Patel, Madhubhai M ^c   Haque, Navedul ^a  

^a JIMMA UNIVERSITY   (Ethiopia)

^b B V PATEL PHARMACEUTICAL EDUCATION AND RESEARCH DEVELOPMENT PERD CENTRE   (India)

^c GANPAT UNIVERSITY   (India)

Author keywords

Analgesic activity; Anti inflammatory activity; Antioxidant activity; COX inhibitors; Tetrasubstituted thiophenes

Indexed keywords

2 (4 METHOXYANILINO) 5 (4 NITROBENZOYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID; 2 (4 METHOXYLANILINO) 5 (3 NITROBENZOYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID; 2 (4 METHYLANILINO) 5 (3 NITROBENZOYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID; 2 (4 METHYLANILINO) 5 (4 CHLOROBENZOYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID; 2 (4 METHYLANILINO) 5 (4 NITROBENZOYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID; 2 ANILINO 5 (4 NITROBENZOYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID; ANTIINFLAMMATORY AGENT; ASCORBIC ACID; IBUPROFEN; MEFENAMIC ACID; METHYL 2 (2 FUROYLAMINO) 5 (2,4 DICHLOROBENZOYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID; METHYL 2 (2 FUROYLAMINO) 5 (3 NITROBENZOYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID; METHYL 2 (2 FUROYLAMINO) 5 (4 METHOXYBENZOYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID; METHYL 2 (2 FUROYLAMINO) 5 (4 NITROBENZOYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID; METHYL 2 (4 METHOXYANILINO) 5 (4 NITROBENZOYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID; METHYL 2 (4 METHOXYCANILINO) 5 (3 NITROBENZOYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID; METHYL 2 (4 METHYLANILINO) 5 (3 NITROBENZOYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID; METHYL 2 (4 METHYLANILINO) 5 (4 CHLOROBENZOYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID; METHYL 2 (4 METHYLANILINO) 5 (4 NITROBENZOYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID; METHYL 2 ANILINO 5 (4 NITROBENZOYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID; METHYL 2 BENZOYLANILINO 5 (2,4 DICHLOROBENZOYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID; METHYL 2 BENZOYLANILINO 5 (3 NITROBENZOYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID; METHYL 2 BENZOYLANILINO 5 (4 METHOXYBENZOYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID; METHYL 2 BENZOYLANILINO 5 (4 METHYLBENZOYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID; METHYL 2 BENZOYLANILINO 5 (4 NITROBENZOYL) 4 METHYLTHIOPHENE 3 CARBOXYLIC ACID; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG DOSE COMPARISON; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; IN VITRO STUDY; MALE; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; RAT; WRITHING TEST;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; DRUG DESIGN; EDEMA; FEMALE; MALE; MOLECULAR STRUCTURE; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

MUS; RATTUS;

EID: 56449085002     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360701608692     Document Type: Article

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