Dexamethasone induces dendritic alteration but not apoptosis in the neurons of the hippocampus in postnatal rats

Neuroscience Letters

Volumn 326, Issue 3, 2002, Pages 206-210

  Tan, C K ^a   Yan, J ^a   Ananth, C ^a   Kaur, C ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Dexamethasone; Hippocampus; Neuronal apoptosis; Postnatal rats

Indexed keywords

CASPASE 3; DEXAMETHASONE; ENZYME ANTIBODY; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2; SODIUM CHLORIDE; GLUCOCORTICOID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN NERVE CELL; CELL ULTRASTRUCTURE; CELL VACUOLE; CONTROLLED STUDY; DENDRITE; DENTATE GYRUS; GRANULE CELL; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; DRUG EFFECT; ELECTRON MICROSCOPY; NERVE CELL; NEWBORN; PATHOLOGY; ULTRASTRUCTURE;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; DENDRITES; DEXAMETHASONE; GLUCOCORTICOIDS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MICROSCOPY, ELECTRON; NEURONS; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0037025084     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(02)00349-X     Document Type: Article

References (17)

1. Subtle shifts in the ratio between pro- and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate
2. Domoic acid-induced neuronal damage in the rat hippocampus: Changes in apoptosis related genes (Bcl-2, Bax, caspase-3) and microglial response
3. The adverse neuro-developmental effects of postnatal steroids in the preterm infant: A systematic review of RCTs
4. Dexamethasone prevents apoptosis in a neonatal rat model of hypoxic-ischemic encephalopathy (HIE) by a reactive oxygen species-independent mechanism
5. New members of the Bcl-2 family and their protein partners
6. Neonatal dexamethasone on day 7 causes mild hyperactivity and cerebellar stunting
7. Neonatal dexamethasone on day 7 in rats causes behavioral alterations reflective of hippocampal, but not cerebellar, deficits
8. Adrenal steroids regulate postnatal development of the rat dentate gyrus: I. Effects of glucocorticoids on cell death
9. Naturally occurring cell death in the developing dentate gyrus of the rat
10. Dexamethasone induces limited apoptosis and extensive sublethal damage to specific subregions of the striatum and hippocampus: Implications for mood disorders
11. Bcl-2 and Bax function independently to regulate cell death
12. Bcl-2 gene family in the nervous system
13. Randomized placebo-controlled trial of a 42-day tapering course of dexamethasone to reduce the duration of ventilator dependency in very low birth weight infants: Outcome of study participants at 1-year adjusted age
14. Controversies surrounding glucocorticoid-mediated cell death in the hippocampus
15. Perinatal glucocorticoids disrupt learning: A sexually dimorphic response
16. Antenatal steroids and the developing brain
17. Early postnatal dexamethasone therapy for the prevention of chronic lung disease in preterm infants with respiratory distress syndrome: A multicenter clinical trial