Mechanism of carcinogenesis induced by a veterinary antimicrobial drug, nitrofurazone, via oxidative DNA damage and cell proliferation

Cancer Letters

Volumn 215, Issue 2, 2004, Pages 141-150

  Hiraku, Yusuke ^a   Sekine, Aki ^a   Nabeshi, Hiromi ^a   Midorikawa, Kaoru ^a   Murata, Mariko ^a   Kumagai, Yoshito ^b   Kawanishi, Shosuke ^a  

^a MIE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Cytochrome P450 reductase; DNA damage; Estrogenic activity; Initiation; Nitrofurazone; Promotion

Indexed keywords

ALCOHOL; ANTIINFECTIVE AGENT; BATHOCUPROINE; CATALASE; CHELATING AGENT; COPPER; CYTOCHROME P450 REDUCTASE; DNA; DNA FRAGMENT; DRUG METABOLITE; ESTRADIOL; ESTROGEN; FORMATE SODIUM; MANNITOL; METHIONAL; NITROFURAL; PHOSPHORUS 32; PROTEIN P53; SCAVENGER; UNCLASSIFIED DRUG;

ARTICLE; CANCER; CARCINOGENESIS; CELL PROLIFERATION; CELL STIMULATION; CELL STRAIN MCF 7; CONTROLLED STUDY; DISEASE COURSE; DNA DAMAGE; DNA SEQUENCE; HUMAN; HUMAN CELL; ISOTOPE LABELING; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL;

ANTI-INFECTIVE AGENTS; CARCINOGENICITY TESTS; CARCINOGENS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA DAMAGE; FREE RADICALS; GENES, P53; HUMANS; NADPH-FERRIHEMOPROTEIN REDUCTASE; NEOPLASMS, HORMONE-DEPENDENT; NITROFURAZONE; OXIDATION-REDUCTION; OXIDATIVE STRESS;

ANIMALIA; MINK CELL FOCUS-FORMING VIRUS;

EID: 5644244248     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2004.05.016     Document Type: Article

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