Electronic spin resonance detection of superoxide and hydroxyl radicals during the reductive metabolism of drugs by rat brain preparations and isolated cerebral microvessels

Free Radical Biology and Medicine

Volumn 24, Issue 7-8, 1998, Pages 1074-1081

  Ghersi Egea, Jean François ^a   Maupoil, Véronique ^b,d   Ray, David ^c   Rochette, Luc ^d  

^a INSTITUT PASTEUR DE LILLE   (France)

^b UNIVERSITÉ DE FRANCHE COMTÉ   (France)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

^d UNIVERSITÉ DE BOURGOGNE   (France)

Author keywords

Blood brain barrier; Drug metabolism; Free radical; Imminium; Nitro compounds; Quinone

Indexed keywords

1,4 BENZOQUINONE; DEFEROXAMINE; DIMETHYL SULFOXIDE; FREE RADICAL; HETEROCYCLIC NITRO COMPOUND; HYDROXYL RADICAL; MENADIONE; NITROFURAL; PARAQUAT; PYRIDINIUM DERIVATIVE; SUPEROXIDE; SUPEROXIDE DISMUTASE; XENOBIOTIC AGENT;

ARTICLE; BLOOD BRAIN BARRIER; BRAIN; BRAIN METABOLISM; BRAIN MICROCIRCULATION; DRUG METABOLISM; ELECTRON SPIN RESONANCE; PRIORITY JOURNAL; XENOBIOTIC METABOLISM;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; ELECTRON SPIN RESONANCE SPECTROSCOPY; ELECTRON TRANSPORT; HYDROXYL RADICAL; MALE; MICROCIRCULATION; NAD; NADP; NITROFURAZONE; OXIDATION-REDUCTION; PARAQUAT; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDES; VITAMIN K; XENOBIOTICS;

EID: 0032078722     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(97)00387-0     Document Type: Article

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