A mechanistic study of ovarian carcinogenesis induced by nitrofurazone using rasH2 mice

Toxicologic Pathology

Volumn 28, Issue 5, 2000, Pages 649-655

  Takegawa, K ^a   Mitsumori, K ^a   Yasuhara, K ^a   Moriyasu, M ^a   Sakamori, M ^a   Onodera, H ^a   Hirose, M ^a   Nomura, T ^a  

^a NONE   (Japan)

Author keywords

Endocrine gland; Granulosa cell; Ovarian atrophy; Transgenic mouse

Indexed keywords

CYCLINE; GONADOTROPIN; LUTEINIZING HORMONE; NITROFURAL;

ARTICLE; ATROPHY; CARCINOGENESIS; CARCINOGENICITY; CONTROLLED STUDY; FEMALE; GENOTOXICITY; GRANULOSA CELL; HISTOPATHOLOGY; MALE; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; ONCOGENE RAS; OVARY CANCER; OVARY FOLLICLE ATRESIA; PRIORITY JOURNAL; RAT STRAIN; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS;

EID: 0033793721     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/019262330002800503     Document Type: Article

References (23)

1. Granulosa cell tumor, ovary, mouse
2. Ovary
3. Nitrofurazone-genotoxicity studies in mammalian cells in vitro and in vivo
4. Preliminary studies on the ability of Drosophila microsomal preparations to activate mutagens and carcinogens
5. Estrogen receptor-beta mRNA expression in rat ovary: Down-regulation by gonadotropins
6. Effect of corticotropin-releasing hormone on ovarian estrogen production in vitro
7. A morphologic classification and incidence of spontaneous ovarian neoplasms in three strains of mice
8. Studies on the effect of ascorbic acid and selenium on the genotoxicity of nitrofurans: Nitrofurazone and furazolidone
9. Animal models for tumors of the ovary
10. Pathological features of spontaneous and induced tumors in transgenic mice carrying a human prototype c-Ha-ras gene used for six-month carcinogenicity studies
11. Susceptibility of transgenic mice carrying human prototype c-Ha-ras gene in a short-term carcinogenicity study of vinyl carbamate and ras gene analysis of the induced tumors
12. Major experimental models of ovarian tumors: Histogenesis and evaluation
13. Sequential observation of spontaneous endometrial adenocarcinoma development in Donryu rats
14. Damage to mammalian cell DNA by nitrofurans
15. Spontaneous ovarian tumors in Han: NMRI mice: Histologic classification, incidence, and influence of food restriction
16. Chromosome aberrations and DNA repair synthesis in cultured human cells exposed to nitrofurans
17. Rapid carcinogenic response of transgenic mice harboring the human prototype c-Ha-ras gene to various carcinogens
18. Rapid carcinogenicity testing system with transgenic mice harboring human prototype c-HRAS gene
19. Rapid induction of more malignant tumors by various genotoxic carcinogens in transgenic mice harboring a human prototype c-Ha-ras gene than in control non-transgenic mice
20. Validation of transgenic mice carrying the human prototype c-Ha-ras gene as a bioassay model for rapid carcinogenicity testing