Glial cell-derived neurotrophic factor gene delivery enhances survival of human corneal epithelium in culture and the overexpression of GDNF in bioengineered constructs

Experimental Eye Research

Volumn 87, Issue 6, 2008, Pages 580-586

  Qi, Hong ^a,d   David Shine, H ^b,c   Li, De Quan ^a   de Paiva, Cintia S ^a   Farley, William J ^a   Jones, Dan B ^a   Pflugfelder, Stephen C ^a  

^a CULLEN EYE INSTITUTE   (United States)

^b CENTER FOR CELL AND GENE THERAPY   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d PEKING UNIVERSITY   (China)

Author keywords

adenoviral vector; bioengineering; cornea; epithelium; gene therapy; glial cell derived neurotrophic factor

Indexed keywords

ADENOVIRUS VECTOR; ENHANCED GREEN FLUORESCENT PROTEIN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR;

ARTICLE; AUTOGRAFT; BIOENGINEERING; CELL CULTURE; CELL POPULATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CORNEA EPITHELIUM; EX VIVO STUDY; GENE TARGETING; HUMAN; HUMAN CELL; NICK END LABELING; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENOVIRIDAE; ADULT; AGED; BIOMEDICAL ENGINEERING; CELL SURVIVAL; CELLS, CULTURED; CORNEAL TRANSPLANTATION; EPITHELIUM, CORNEAL; GENE THERAPY; GENETIC VECTORS; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HUMANS; MIDDLE AGED; STEM CELLS; TRANSDUCTION, GENETIC; YOUNG ADULT;

EID: 56349158379     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2008.09.012     Document Type: Article

References (36)

1. Ang L.P., and Tan D.T. Ocular surface stem cells and disease: current concepts and clinical applications. Ann. Acad. Med. Singapore 33 (2004) 576-580
2. Araki-Sasaki K., Ohashi Y., Sasabe T., Hayashi K., Watanabe H., Tano Y., and Handa H. An SV40-immortalized human corneal epithelial cell line and its characterization. Investig. Ophthalmol. Vis. Sci. 36 (1995) 614-621
3. Baumgartner B.J., and Shine H.D. Targeted transduction of CNS neurons with adenoviral vectors carrying neurotrophic factor genes confers neuroprotection that exceeds the transduced population. J. Neurosci. 17 (1997) 6504-6511
4. Baumgartner B.J., and Shine H.D. Neuroprotection of spinal motoneurons following targeted transduction with an adenoviral vector carrying the gene for glial cell line-derived neurotrophic factor. Exp. Neurol. 153 (1998) 102-112
5. Borras T., Gabelt B.T., Klintworth G.K., Peterson J.C., and Kaufman P.L. Non-invasive observation of repeated adenoviral GFP gene delivery to the anterior segment of the monkey eye in vivo. J. Gene Med. 3 (2001) 437-449
6. Borras T., Tamm E.R., and Zigler Jr. J.S. Ocular adenovirus gene transfer varies in efficiency and inflammatory response. Investig. Ophthalmol. Vis. Sci. 37 (1996) 1282-1293
7. Bradshaw J.J., Obritsch W.F., Cho B.J., Gregerson D.S., and Holland E.J. Ex vivo transduction of corneal epithelial progenitor cells using a retroviral vector. Investig. Ophthalmol. Vis. Sci. 40 (1999) 230-235
8. Chen Z., De Paiva C.S., Luo L., Kretzer F.L., Pflugfelder S.C., and Li D.-Q. Characterization of putative stem cell phenotype in human limbal epithelia. Stem Cells 22 (2004) 355-366
9. Fehervari Z., Rayner S.A., Oral H.B., George A.J., and Larkin D.F. Gene transfer to ex vivo stored corneas. Cornea 16 (1997) 459-464
10. Fibbe W.E., Daha M.R., Hiemstra P.S., Duinkerken N., Lurvink E., Ralph P., Altrock B.W., Kaushansky K., Willemze R., and Falkenburg J.H. Interleukin 1 and poly(rI).poly(rC) induce production of granulocyte CSF, macrophage CSF, and granulocyte-macrophage CSF by human endothelial cells. Exp. Hematol. 17 (1989) 229-234
11. Frasson M., Picaud S., Leveillard T., Simonutti M., Mohand-Said S., Dreyfus H., Hicks D., and Sabel J. Glial cell line-derived neurotrophic factor induces histologic and functional protection of rod photoreceptors in the rd/rd mouse. Investig. Ophthalmol. Vis. Sci. 40 (1999) 2724-2734
12. Hoffman L.M., Maguire A.M., and Bennett J. Cell-mediated immune response and stability of intraocular transgene expression after adenovirus-mediated delivery. Investig. Ophthalmol. Vis. Sci. 38 (1997) 2224-2233
13. Kim H.S., Jun S.X., De Paiva C.S., Chen Z., Pflugfelder S.C., and Li D.-Q. Phenotypic characterization of human corneal epithelial cells expanded ex vivo from limbal explant and single cell cultures. Exp. Eye Res. 79 (2004) 41-49
14. Klausner E.A., Peer D., Chapman R.L., Multack R.F., and Andurkar S.V. Corneal gene therapy. J. Control Release 124 (2007) 107-133
15. Klebe S., Sykes P.J., Coster D.J., Krishnan R., and Williams K.A. Prolongation of sheep corneal allograft survival by ex vivo transfer of the gene encoding interleukin-10. Transplantation 71 (2001) 1214-1220
16. Koeberle P.D., and Ball A.K. Effects of GDNF on retinal ganglion cell survival following axotomy. Vision Res. 38 (1998) 1505-1515
17. Koizumi N., Inatomi T., Suzuki T., Sotozono C., and Kinoshita S. Cultivated corneal epithelial stem cell transplantation in ocular surface disorders. Ophthalmology 108 (2001) 1569-1574
18. Mashhour B., Couton D., Perricaudet M., and Briand P. In vivo adenovirus-mediated gene transfer into ocular tissues. Gene Ther. 1 (1994) 122-126
19. Massague J., Attisano L., and Wrana J.L. The TGF-beta family and its composite receptors. Trends Cell Biol. 4 (1994) 172-178
20. Meng X., Lindahl M., Hyvonen M.E., Parvinen M., de Rooij D.G., Hess M.W., Raatikainen-Ahokas A., Sainio K., Rauvala H., Lakso M., Pichel J.G., Westphal H., Saarma M., and Sariola H. Regulation of cell fate decision of undifferentiated spermatogonia by GDNF. Science 287 (2000) 1489-1493
21. Mohan R.R., Sharma A., Netto M.V., Sinha S., and Wilson S.E. Gene therapy in the cornea. Prog. Retin. Eye Res. 24 (2005) 537-559
22. Nishida K., Yamato M., Hayashida Y., Watanabe K., Maeda N., Watanabe H., Yamamoto K., Nagai S., Kikuchi A., Tano Y., and Okano T. Functional bioengineered corneal epithelial sheet grafts from corneal stem cells expanded ex vivo on a temperature-responsive cell culture surface. Transplantation 77 (2004) 379-385
23. Oatley J.M., Avarbock M.R., Telaranta A.I., Fearon D.T., and Brinster R.L. Identifying genes important for spermatogonial stem cell self-renewal and survival. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 9524-9529
24. Pellegrini G., Traverso C.E., Franzi A.T., Zingirian M., Cancedda R., and De Luca M. Long-term restoration of damaged corneal surfaces with autologous cultivated corneal epithelium. Lancet 349 (1997) 990-993
25. Qi H., Chuang E.Y., Yoon K.C., de Paiva C.S., Shine H.D., Jones D.B., Pflugfelder S.C., and Li D.-Q. Patterned expression of neurotrophic factors and receptors in human limbal and corneal regions. Mol. Vis. 13 (2007) 1934-1941
26. Rosenblatt M.I., and Azar D.T. Gene therapy of the corneal epithelium. Int. Ophthalmol. Clin. 44 (2004) 81-90
27. Schwab I.R., Reyes M., and Isseroff R.R. Successful transplantation of bioengineered tissue replacements in patients with ocular surface disease. Cornea 19 (2000) 421-426
28. Tong L., Chen Z., De Paiva C.S., Beuerman R., Li D.-Q., and Pflugfelder S.C. Transglutaminase participates in UVB-induced cell death pathways in human corneal epithelial cells. Investig. Ophthalmol. Vis. Sci. 47 (2006) 4295-4301
29. Tsai R.J., Li L.M., and Chen J.K. Reconstruction of damaged corneas by transplantation of autologous limbal epithelial cells. N. Engl. J. Med. 343 (2000) 86-93
30. Tsubota K., Inoue H., Ando K., Ono M., Yoshino K., and Saito I. Adenovirus-mediated gene transfer to the ocular surface epithelium. Exp. Eye Res. 67 (1998) 531-538
31. Wang X., Appukuttan B., Ott S., Patel R., Irvine J., Song J., Park J.H., Smith R., and Stout J.T. Efficient and sustained transgene expression in human corneal cells mediated by a lentiviral vector. Gene Ther. 7 (2000) 196-200
32. Watanabe K., Yamato M., Hayashida Y., Yang J., Kikuchi A., Okano T., Tano Y., and Nishida K. Development of transplantable genetically modified corneal epithelial cell sheets for gene therapy. Biomaterials 28 (2007) 745-749
33. Yan Q., Wang J., Matheson C.R., and Urich J.L. Glial cell line-derived neurotrophic factor (GDNF) promotes the survival of axotomized retinal ganglion cells in adult rats: comparison to and combination with brain-derived neurotrophic factor (BDNF). J. Neurobiol. 38 (1999) 382-390
34. Yeh S., Song X.J., Farley W., Li D.-Q., Stern M.E., and Pflugfelder S.C. Apoptosis of ocular surface cells in experimentally induced dry eye. Investig. Ophthalmol. Vis. Sci. 44 (2003) 124-129
35. You L., Ebner S., and Kruse F.E. Glial cell-derived neurotrophic factor (GDNF)-induced migration and signal transduction in corneal epithelial cells. Investig. Ophthalmol. Vis. Sci. 42 (2001) 2496-2504
36. Zhou L., and Shine H.D. Neurotrophic factors expressed in both cortex and spinal cord induce axonal plasticity after spinal cord injury. J. Neurosci. Res. 74 (2003) 221-226