Interleukin-6-174-genotype, sepsis and cerebral injury in very low birth weight infants

Genes and Immunity

Volumn 7, Issue 1, 2006, Pages 65-68

  Gopel W ^a   Hartel C ^a   Ahrens, P ^a   Konig I ^a   Kattner, E ^b   Kuhls, E ^c   Kuster H ^d   Moller J ^e   Muller D ^f   Roth, B ^g   Segerer, H ^h   Wieg, C ⁱ   Herting, E ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

^b Kinderklinik auf der Bult   (Germany)

^c OLGAHOSPITAL   (Germany)

^d UNIVERSITY OF GREIFSWALD   (Germany)

^e Childrens Hospital Saarbrucken   (Germany)

^f Children's Hospital   (Germany)

^g UNIVERSITY OF COLOGNE   (Germany)

^h Kinderklinik St Hedwig   (Germany)

ⁱ KLINIKUM ASCHAFFENBURG   (Germany)

Author keywords

Interleukin 6; Intraventricular hemorrhage; Preterm infants; Sepsis

Indexed keywords

INTERLEUKIN 6; INTERLEUKIN 6 174; UNCLASSIFIED DRUG;

ARTICLE; BLOOD CULTURE; BRAIN HEMORRHAGE; BRAIN INJURY; BRAIN VENTRICLE PERITONEUM SHUNT; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; ENCEPHALOMALACIA; FEMALE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HETEROZYGOTE; HUMAN; INFANT; INFANT MORTALITY; MAJOR CLINICAL STUDY; MALE; PREMATURITY; PRIORITY JOURNAL; SEPSIS; VERY LOW BIRTH WEIGHT;

BLOOD; CEREBRAL HEMORRHAGE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, VERY LOW BIRTH WEIGHT; INTERLEUKIN-6; LEUKOMALACIA, PERIVENTRICULAR; MALE; PROMOTER REGIONS, GENETIC; SEPSIS; VENTRICULOPERITONEAL SHUNT;

EID: 33645137794     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/sj.gene.6364264     Document Type: Article

References (9)

1. Harding D, Dhamrait S, Millar A, Humphries S, Marlow N, Whitelaw A et al. Is interleukin-6-174 genotype associated with the development of septicemia in preterm infants? Pediatrics 2003; 112: 800-803.
2. Ahrens P, Kattner W, Köhler B, Härtel C, Seidenberg J, Segerer H et al. Mutations of genes involved in the innate immune system as predictors of sepsis in very low birth weight infants. Pediatr Res 2004; 55: 652-656.
3. Harding DR, Dhamrait S, Whitelaw A, Humphries SE, Marlow N, Montgomery HE. Does interleukin6 genotype influence cerebral injury or developmental progress after preterm birth? Pediatrics 2004; 114: 941-947.
4. Kilpinen S, Hulkkonen J, Wang XY, Hurme M. The promoter polymorphism of the interleukin-6 gene regulates interleukin-6 production in neonates but not in adults. Eur Cytokine Network 2001; 12: 62-68.
5. Endler G, Marsik C, Joukhadar C, Marculescu R, Mayr F, Mannhalter C et al. The interleukin-6 G(-174)C promoter polymorphism does not determine plasma interleukin-6 concentrations in experimental endotoxemia in humans. Clin Chem 2004; 50: 195-200.
6. Fishman D, Faulds G, Jeffery R, Mohamed-Ali V, Yudkin JS, Humphries S et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 1998; 102: 1369-1376.
7. Bennermo M, Held C, Stemme S, Ericsson CG, Silveira A, Green F et al. Genetic predisposition of the interleukin-6 response to inflammation: implications for a variety of major diseases? Clin Chem 2004; 50: 2136-2140.
8. Treszl A, Kocsis I, Szathmari M, Schuler A, Heninger E, Tulassay T et al. Genetic variants of TNF-alpha, IL-1beta, IL-4 receptor-alpha-chain, IL-6 and IL-10 genes are not risk factors for sepsis in low-birth-weight infants. Biol Neonate 2003; 83: 241-245.
9. Sutherland AM, Walley KR, Manocha S, Russell JA. The association of interleukin 6 haplotype clades with mortality in critically ill adults. Arch Intern Med 2005; 165: 75-82.