Synthesis of spiro-1,2-dioxolanes and their activity against Plasmodium falciparum

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 24, 2008, Pages 6521-6524

  Martyn, Derek C ^a   Ramirez, Armando P ^b   Beattie, Meaghan J ^a   Cortese, Joseph F ^a   Patel, Vishal ^a,c   Rush, Margaret A ^a,c   Woerpel, K A ^b   Clardy, Jon ^a,c  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Dioxolane; Endoperoxide; Malaria; Plasmodium

Indexed keywords

ANTIMALARIAL AGENT; ARTEMISIN; CHLOROQUINE; MOLECULAR SCAFFOLD; OZ 277; SPIRO 1,2 DIOXOLANE DERIVATIVE; SPIRO COMPOUND; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; DIASTEREOISOMER; DRUG SYNTHESIS; NONHUMAN; PLASMODIUM FALCIPARUM; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

AMINES; AMINO ACID MOTIFS; ANIMALS; ANTIGENS, PROTOZOAN; ANTIMALARIALS; ANTIPROTOZOAL AGENTS; CHEMISTRY, PHARMACEUTICAL; DIOXOLANES; DRUG DESIGN; HEME; HUMANS; MALARIA; MODELS, CHEMICAL; PEROXIDES; PLASMODIUM FALCIPARUM;

PLASMODIUM FALCIPARUM;

EID: 56249138250     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.10.083     Document Type: Article

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