메뉴 건너뛰기




Volumn 19, Issue 3, 2008, Pages 107-113

Bevirimat: A novel maturation inhibitor for the treatment of HIV-1 infection

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; ATAZANAVIR; BEVIRIMAT; GAG PROTEIN; NUCLEOSIDE; PLACEBO; PROTEINASE INHIBITOR; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR;

EID: 56249119547     PISSN: 09563202     EISSN: None     Source Type: Journal    
DOI: 10.1177/095632020801900301     Document Type: Review
Times cited : (88)

References (43)
  • 1
    • 35348888625 scopus 로고    scopus 로고
    • AIDS: Is there an answer to the global pandemic? The immune system in HIV infection and control
    • Maplanka C. AIDS: is there an answer to the global pandemic? The immune system in HIV infection and control. Viral Immunol 2007; 20:331-342.
    • (2007) Viral Immunol , vol.20 , pp. 331-342
    • Maplanka, C.1
  • 2
    • 0038679007 scopus 로고    scopus 로고
    • Challenges of the unmet needs in the treatment-experienced patient
    • Montaner JS. Challenges of the unmet needs in the treatment-experienced patient. AIDS Read 2003; 13 Suppl 6:S5-S9.
    • (2003) AIDS Read , vol.13 , Issue.SUPPL. 6
    • Montaner, J.S.1
  • 3
    • 33645566339 scopus 로고    scopus 로고
    • Limitations of current antiretroviral agents and opportunities for development
    • Jain R, Clark NM, Diaz-Linares M, Grim SA. Limitations of current antiretroviral agents and opportunities for development. Curr Pharm Des 2006; 12:1065-1074.
    • (2006) Curr Pharm Des , vol.12 , pp. 1065-1074
    • Jain, R.1    Clark, N.M.2    Diaz-Linares, M.3    Grim, S.A.4
  • 4
    • 33750322006 scopus 로고    scopus 로고
    • Changing antiretroviral therapy in the setting of virologic relapse: Review of the current literature
    • Anderson AM, Bartlett JA. Changing antiretroviral therapy in the setting of virologic relapse: review of the current literature. Curr HIV/AIDS Rep 2006; 3:79-85.
    • (2006) Curr HIV/AIDS Rep , vol.3 , pp. 79-85
    • Anderson, A.M.1    Bartlett, J.A.2
  • 5
    • 24144500343 scopus 로고    scopus 로고
    • Approach to the treatment-experienced patient
    • Gallant JE. Approach to the treatment-experienced patient. Curr HIV/ AIDS Rep 2005; 2:83-89.
    • (2005) Curr HIV/ AIDS Rep , vol.2 , pp. 83-89
    • Gallant, J.E.1
  • 6
    • 32944471634 scopus 로고    scopus 로고
    • Management of HIV-infected patients with multidrug-resistant virus
    • Harris M, Montaner JS. Management of HIV-infected patients with multidrug-resistant virus. Curr HIV/AIDS Rep 2004; 1:116-121.
    • (2004) Curr HIV/AIDS Rep , vol.1 , pp. 116-121
    • Harris, M.1    Montaner, J.S.2
  • 7
    • 0347995130 scopus 로고    scopus 로고
    • Treatment of antiretroviral-drug-resistant HIV-1 infection
    • Deeks SG. Treatment of antiretroviral-drug-resistant HIV-1 infection. Lancet 2004; 362:2002-2011.
    • (2004) Lancet , vol.362 , pp. 2002-2011
    • Deeks, S.G.1
  • 8
    • 20244384565 scopus 로고    scopus 로고
    • French national sentinel survey of antiretroviral drug resistance in patients with HIV-1 primary infection and in antiretroviral-naive chronically infected patients in 2001-2002
    • Descamps D, Chaix ML, André P, et al. French national sentinel survey of antiretroviral drug resistance in patients with HIV-1 primary infection and in antiretroviral-naive chronically infected patients in 2001-2002. J Acquir Immune Defic Syndr 2005; 38:545-552.
    • (2005) J Acquir Immune Defic Syndr , vol.38 , pp. 545-552
    • Descamps, D.1    Chaix, M.L.2    André, P.3
  • 9
    • 0037043652 scopus 로고    scopus 로고
    • Antiretroviral-drug resistance among patients recently infected with HIV
    • Little SJ, Holte S, Routy JP, et al. Antiretroviral-drug resistance among patients recently infected with HIV. N Engl J Med 2002; 347:385-394.
    • (2002) N Engl J Med , vol.347 , pp. 385-394
    • Little, S.J.1    Holte, S.2    Routy, J.P.3
  • 10
    • 16544376890 scopus 로고    scopus 로고
    • Primary drug-resistance in HIV-positive patients on initiation of first-line antiretroviral therapy in Germany
    • Oette M, Kaiser R, Daumer M, et al. Primary drug-resistance in HIV-positive patients on initiation of first-line antiretroviral therapy in Germany. Eur J Med Res 2004; 9:273-278.
    • (2004) Eur J Med Res , vol.9 , pp. 273-278
    • Oette, M.1    Kaiser, R.2    Daumer, M.3
  • 11
    • 33745436260 scopus 로고    scopus 로고
    • A population-based approach to determine the prevalence of transmitted drug-resistant HIV among recent versus established HIV infections: Results from the Canadian HIV strain and drug resistance surveillance program
    • Jayaraman GC, Archibald CP, Kim J, et al. A population-based approach to determine the prevalence of transmitted drug-resistant HIV among recent versus established HIV infections: results from the Canadian HIV strain and drug resistance surveillance program. J Acquir Immune Defic Syndr 2006; 42:86-90.
    • (2006) J Acquir Immune Defic Syndr , vol.42 , pp. 86-90
    • Jayaraman, G.C.1    Archibald, C.P.2    Kim, J.3
  • 12
    • 27444442983 scopus 로고    scopus 로고
    • Should resistance testing be performed for treatment-naive HIV-infected patients? A cost-effectiveness analysis
    • Sax PE, Islam R, Walensky RP, et al. Should resistance testing be performed for treatment-naive HIV-infected patients? A cost-effectiveness analysis. Clin Infect Dis 2005; 41:1316-1323.
    • (2005) Clin Infect Dis , vol.41 , pp. 1316-1323
    • Sax, P.E.1    Islam, R.2    Walensky, R.P.3
  • 13
  • 14
    • 18744416007 scopus 로고    scopus 로고
    • Highly active antiretroviral therapy: Current state of the art, new agents and their pharmacological interactions useful for improving therapeutic outcome
    • Barbaro G, Scozzafava A, Mastrolorenzo A, Supuran CT. Highly active antiretroviral therapy: current state of the art, new agents and their pharmacological interactions useful for improving therapeutic outcome. Curr Pharm Des 2005; 11:1805-1843.
    • (2005) Curr Pharm Des , vol.11 , pp. 1805-1843
    • Barbaro, G.1    Scozzafava, A.2    Mastrolorenzo, A.3    Supuran, C.T.4
  • 15
    • 36749088862 scopus 로고    scopus 로고
    • HIV drug development: The next 25 years
    • Flexner C. HIV drug development: the next 25 years. Nature Rev Drug Discov 2007; 6:959-966.
    • (2007) Nature Rev Drug Discov , vol.6 , pp. 959-966
    • Flexner, C.1
  • 16
    • 14744276810 scopus 로고    scopus 로고
    • Orally active antiviral tripeptide glycyl-prolyl-glycinamide is activated by CD26 (dipeptidyl peptidase IV) before transport across the intestinal epithelium
    • Hubatsch I, Lazorova L, Vahlne A, Artursson P. Orally active antiviral tripeptide glycyl-prolyl-glycinamide is activated by CD26 (dipeptidyl peptidase IV) before transport across the intestinal epithelium. Antimicrob Agents Chemother 2005; 49:1087-1092.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 1087-1092
    • Hubatsch, I.1    Lazorova, L.2    Vahlne, A.3    Artursson, P.4
  • 17
    • 0345686713 scopus 로고    scopus 로고
    • PA-457: A potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing
    • Li F, Goila-Gaur R, Salzwedel K, et al. PA-457: a potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing. Proc Natl Acad Sci U S A 2003; 100:13555-13560.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 13555-13560
    • Li, F.1    Goila-Gaur, R.2    Salzwedel, K.3
  • 18
    • 33744937903 scopus 로고    scopus 로고
    • 3-O-(3′,3′-dimethysuccinyl) betulinic acid inhibits maturation of the human immunodeficiency virus type 1 gag precursor assembled in vitro
    • Sakalian M, McMurtrey CP, Deeg FJ, et al. 3-O-(3′,3′-dimethysuccinyl) betulinic acid inhibits maturation of the human immunodeficiency virus type 1 gag precursor assembled in vitro. J Virol 2006; 80:5716-5722.
    • (2006) J Virol , vol.80 , pp. 5716-5722
    • Sakalian, M.1    McMurtrey, C.P.2    Deeg, F.J.3
  • 19
    • 0346688636 scopus 로고    scopus 로고
    • Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturation
    • Zhou J, Yuan X, Dismuke D, et al. Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturation. J Virol 2004; 78:922-929.
    • (2004) J Virol , vol.78 , pp. 922-929
    • Zhou, J.1    Yuan, X.2    Dismuke, D.3
  • 20
    • 24344496912 scopus 로고    scopus 로고
    • Emerging drug targets for antiretroviral therapy
    • Reeves JD, Piefer AJ. Emerging drug targets for antiretroviral therapy. Drugs 2005; 65:1747-1766.
    • (2005) Drugs , vol.65 , pp. 1747-1766
    • Reeves, J.D.1    Piefer, A.J.2
  • 21
    • 55349140821 scopus 로고    scopus 로고
    • Determinants of activity of the HIV-1 maturation inhibitor PA-457 map to the N-terminal half of the Gag SP1 domain
    • 25-30 May, Cold Spring Harbor, NY, USA. Session 14
    • Li F, Zoumplis D, Matallana C, et al. Determinants of activity of the HIV-1 maturation inhibitor PA-457 map to the N-terminal half of the Gag SP1 domain. Cold Spring Harbor Laboratory Meeting on Retroviruses. 25-30 May 2004, Cold Spring Harbor, NY, USA. Session 14.
    • (2004) Cold Spring Harbor Laboratory Meeting on Retroviruses
    • Li, F.1    Zoumplis, D.2    Matallana, C.3
  • 22
    • 0028176540 scopus 로고
    • Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids
    • Fujioka T, Kashiwada Y, Kilkuskie RE, et al. Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids. J Nat Prod 1994; 57:243-247.
    • (1994) J Nat Prod , vol.57 , pp. 243-247
    • Fujioka, T.1    Kashiwada, Y.2    Kilkuskie, R.E.3
  • 24
    • 33750990206 scopus 로고    scopus 로고
    • Determinants of activity of the HIV-1 maturation inhibitor PA-457
    • Li F, Zoumplis D, Matallana C, et al. Determinants of activity of the HIV-1 maturation inhibitor PA-457. Virology 2006; 356:217-224.
    • (2006) Virology , vol.356 , pp. 217-224
    • Li, F.1    Zoumplis, D.2    Matallana, C.3
  • 25
    • 43449132695 scopus 로고    scopus 로고
    • Potent activity of the HIV-1 maturation inhibitor bevirimat in SCID-hu Thy/Liv mice
    • Stoddart CA, Joshi P, Sloan B, et al. Potent activity of the HIV-1 maturation inhibitor bevirimat in SCID-hu Thy/Liv mice. PLoS ONE 2007; 2:e1251.
    • (2007) PLoS ONE , vol.2
    • Stoddart, C.A.1    Joshi, P.2    Sloan, B.3
  • 26
    • 4344615371 scopus 로고    scopus 로고
    • The sequence of the CA-SP1 junction accounts for the differential sensitivity of HIV-1 and SIV to the small molecule maturation inhibitor 3-O-{3′,3′-dimethylsuccinyl}-betulinic acid
    • Zhou J, Chen CH, Aiken C. The sequence of the CA-SP1 junction accounts for the differential sensitivity of HIV-1 and SIV to the small molecule maturation inhibitor 3-O-{3′,3′-dimethylsuccinyl}-betulinic acid. Retrovirology 2004; 1:15.
    • (2004) Retrovirology , vol.1 , pp. 15
    • Zhou, J.1    Chen, C.H.2    Aiken, C.3
  • 27
    • 33750695698 scopus 로고    scopus 로고
    • In vitro resistance to the human immunodeficiency virus type 1 maturation inhibitor PA-457 (bevirimat)
    • Adamson CS, Ablan SD, Boeras I, et al. In vitro resistance to the human immunodeficiency virus type 1 maturation inhibitor PA-457 (bevirimat). J Virol 2006; 80:10957-10971.
    • (2006) J Virol , vol.80 , pp. 10957-10971
    • Adamson, C.S.1    Ablan, S.D.2    Boeras, I.3
  • 28
    • 34147127041 scopus 로고    scopus 로고
    • Primary genotypic resistance of HIV-1 to the maturation inhibitor PA-457 in protease inhibitor-experienced patients
    • Malet I, Wirden M, Derache A, et al. Primary genotypic resistance of HIV-1 to the maturation inhibitor PA-457 in protease inhibitor-experienced patients. AIDS 2007; 21:871-873.
    • (2007) AIDS , vol.21 , pp. 871-873
    • Malet, I.1    Wirden, M.2    Derache, A.3
  • 30
    • 34347393916 scopus 로고    scopus 로고
    • The first-in-class maturation inhibitor, PA-457, is a potent inhibitor of HIV-1 drug-resistant isolates and acts synergistically with approved HIV drugs
    • 5-8 February, Denver, CO, USA. Abstract 509
    • Kilgore N, Reddick M, Zuiderhof M, et al. The first-in-class maturation inhibitor, PA-457, is a potent inhibitor of HIV-1 drug-resistant isolates and acts synergistically with approved HIV drugs in vitro. 13th Conference on Retroviruses and Opportunistic Infections. 5-8 February 2006, Denver, CO, USA. Abstract 509.
    • (2006) vitro. 13th Conference on Retroviruses and Opportunistic Infections
    • Kilgore, N.1    Reddick, M.2    Zuiderhof, M.3
  • 32
    • 34948903088 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of bevirimat (PA-457), a novel inhibitor of human immunodeficiency virus maturation, in healthy volunteers
    • Martin DE, Blum R, Wilton J, et al. Safety and pharmacokinetics of bevirimat (PA-457), a novel inhibitor of human immunodeficiency virus maturation, in healthy volunteers. Antimicrob Agents Chemother 2007; 51:3063-3066.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 3063-3066
    • Martin, D.E.1    Blum, R.2    Wilton, J.3
  • 33
    • 34347370621 scopus 로고    scopus 로고
    • Multiple dose pharmacokinetics and safety of bevirimat, a novel inhibitor of human immunodeficiency virus maturation, in healthy volunteers
    • Martin DE, Blum R, Doto J, Galbraith H, Ballow C. Multiple dose pharmacokinetics and safety of bevirimat, a novel inhibitor of human immunodeficiency virus maturation, in healthy volunteers. Clin Pharmacokinet 2007; 46:589-598.
    • (2007) Clin Pharmacokinet , vol.46 , pp. 589-598
    • Martin, D.E.1    Blum, R.2    Doto, J.3    Galbraith, H.4    Ballow, C.5
  • 34
    • 34948888180 scopus 로고    scopus 로고
    • Phase I and II study of the safety, virologic effect, and pharmacokinetics/pharmacodynamics of single-dose 3-O-(3′,3′-dimethylsuccinyl) betulinic acid (bevirimat) against human immunodeficiency virus infection
    • Smith PF, Ogundele A, Forrest A, et al. Phase I and II study of the safety, virologic effect, and pharmacokinetics/pharmacodynamics of single-dose 3-O-(3′,3′-dimethylsuccinyl) betulinic acid (bevirimat) against human immunodeficiency virus infection. Antimicrob Agents Chemother 2007; 51:3574-3581.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 3574-3581
    • Smith, P.F.1    Ogundele, A.2    Forrest, A.3
  • 35
    • 33444474567 scopus 로고    scopus 로고
    • The safety, tolerability and pharmacokinetics of multiple oral doses of PA-457, a first-in-class HIV maturation inhibitor, in healthy volunteers
    • 22-25 February, Boston, MA, USA. Abstract 551
    • Martin DE, Ballow CH, Blum R, Doto J, Wild CT, Allaway GP. The safety, tolerability and pharmacokinetics of multiple oral doses of PA-457, a first-in-class HIV maturation inhibitor, in healthy volunteers. 12th Conference on Retroviruses and Opportunistic Infections. 22-25 February 2005, Boston, MA, USA. Abstract 551.
    • (2005) 12th Conference on Retroviruses and Opportunistic Infections
    • Martin, D.E.1    Ballow, C.H.2    Blum, R.3    Doto, J.4    Wild, C.T.5    Allaway, G.P.6
  • 36
    • 85036892625 scopus 로고    scopus 로고
    • Minimal effect of ritonavir (RTV) on the pharmacokinetics of bevirimat (BVM) in healthy volunteers
    • 22-25 July, Sydney, Australia. Abstract WEPEB015
    • Martin DE, Galbraith H, Schettler J, et al. Minimal effect of ritonavir (RTV) on the pharmacokinetics of bevirimat (BVM) in healthy volunteers. 4th International AIDS Society Conference. 22-25 July 2007, Sydney, Australia. Abstract WEPEB015.
    • (2007) 4th International AIDS Society Conference
    • Martin, D.E.1    Galbraith, H.2    Schettler, J.3
  • 38
    • 85036878321 scopus 로고    scopus 로고
    • Martin DE, Smith P, Goila-Gaur R, et al. Determinants of activity, in vitro metabolism and in vivo disposition of the novel maturation inhibitor PA-457. 11th Conference on Retroviruses and Opportunistic Infections. 8-11 February 2004, San Francisco, CA, USA. Abstract 545.
    • Martin DE, Smith P, Goila-Gaur R, et al. Determinants of activity, in vitro metabolism and in vivo disposition of the novel maturation inhibitor PA-457. 11th Conference on Retroviruses and Opportunistic Infections. 8-11 February 2004, San Francisco, CA, USA. Abstract 545.
  • 39
    • 33747853847 scopus 로고    scopus 로고
    • Structural characterization of anti-HIV drug candidate PA-457 and its acyl glucuronide metabolites in rat bile and human urine and evaluation of in vitro stability by liquid chromatography-electrospray ionization-mass spectrometry
    • Wen Z, Stern ST, Martin DE, Lee KH, Smith PC. Structural characterization of anti-HIV drug candidate PA-457 and its acyl glucuronide metabolites in rat bile and human urine and evaluation of in vitro stability by liquid chromatography-electrospray ionization-mass spectrometry. Drug Metab Dispos 2006; 34:1436-1442.
    • (2006) Drug Metab Dispos , vol.34 , pp. 1436-1442
    • Wen, Z.1    Stern, S.T.2    Martin, D.E.3    Lee, K.H.4    Smith, P.C.5
  • 40
    • 33847375101 scopus 로고    scopus 로고
    • Glucuronidation of anti-HIV drug candidate bevirimat: Identification of human UDP-glucuronosyltransferases and species differences
    • Wen Z, Martin DE, Bullock P, Lee KH, Smith PC. Glucuronidation of anti-HIV drug candidate bevirimat: identification of human UDP-glucuronosyltransferases and species differences. Drug Metab Dispos 2007; 35:440-448.
    • (2007) Drug Metab Dispos , vol.35 , pp. 440-448
    • Wen, Z.1    Martin, D.E.2    Bullock, P.3    Lee, K.H.4    Smith, P.C.5
  • 41
    • 33749519278 scopus 로고    scopus 로고
    • Safety and antiviral activity of PA-457, the first-in-class maturation inhibitor, in a 10-day monotherapy study in HIV-1 infected patients
    • 16-19 December, Washington, DC, USA. Abstract H-416d
    • Beatty G, Jacobson J, Lalezari J, et al. Safety and antiviral activity of PA-457, the first-in-class maturation inhibitor, in a 10-day monotherapy study in HIV-1 infected patients. 45th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. 16-19 December 2005, Washington, DC, USA. Abstract H-416d.
    • (2005) 45th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Beatty, G.1    Jacobson, J.2    Lalezari, J.3
  • 42
    • 1842415431 scopus 로고    scopus 로고
    • Co-receptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype
    • Björndal A, Deng H, Jansson M, et al. Co-receptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype. J Virol 1997; 71:7478-7487.
    • (1997) J Virol , vol.71 , pp. 7478-7487
    • Björndal, A.1    Deng, H.2    Jansson, M.3
  • 43
    • 85036902393 scopus 로고    scopus 로고
    • Multiple dosing of the novel HIV-1 maturation inhibitor bevirimat (BVM): Aggregate adverse event (AE) and laboratory data from four short-term studies
    • 22-25 July, Sydney, Australia. Abstract WEPEA110
    • McCallister S, Doto J, Allaway G, et al. Multiple dosing of the novel HIV-1 maturation inhibitor bevirimat (BVM): aggregate adverse event (AE) and laboratory data from four short-term studies. 4th International AIDS Society Conference. 22-25 July 2007, Sydney, Australia. Abstract WEPEA110.
    • (2007) 4th International AIDS Society Conference
    • McCallister, S.1    Doto, J.2    Allaway, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.