Structural characterization of anti-HIV drug candidate PA-457 [3-O-(3′,3′-dimethylsuccinyl)-betulinic acid] and its acyl glucuronides in rat bile and evaluation of in vitro stability in human and animal liver microsomes and plasma

Drug Metabolism and Disposition

Volumn 34, Issue 9, 2006, Pages 1436-1442

  Wen, Zhiming ^a   Stern, Stephan T ^a,c   Martin, David E ^b   Lee, Kuo Hsiung ^a   Smith, Philip C ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b Panacos Pharmaceuticals   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 O (3',3' DIMETHYLSUCCINYL) BETULINIC ACID; 3 O (3,3 DIMETHYLSUCCINYL)BETULIC ACID; ACYL GLUCURONIDE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BETA GLUCURONIDASE; BETULIC ACID; DIMETHYLSUCCINIC ACID; GLUCURONIDE; GLUCURONOSYLTRANSFERASE; SUCCINIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BILE; BLOOD LEVEL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ELIMINATION; DRUG METABOLISM; DRUG SCREENING; DRUG STABILITY; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; GLUCURONIDATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ANALYSIS;

ANIMALS; ANTI-HIV AGENTS; BILE; BIOTRANSFORMATION; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; GLUCURONIDES; HUMANS; LIVER; MALE; MICE; MICROSOMES, LIVER; MOLECULAR STRUCTURE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUCCINATES; TRITERPENES;

ANIMALIA; RODENTIA;

EID: 33747853847     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.106.009233     Document Type: Article

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