Inhibition of pontine noradrenergic A7 cells reduces hypoglossal nerve activity in rats

Neuroscience

Volumn 157, Issue 2, 2008, Pages 473-482

  Fenik, V B ^a   Rukhadze, I ^a   Kubin, L ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

locus coeruleus; norepinephrine; obstructive sleep apnea; pons; sleep; upper airway

Indexed keywords

12 ETHYLSULFONYL 5,8,8A,9,10,11,12,12A,13,13A DECAHYDRO 3 METHOXY 6H ISOQUINO[2,1 G][1,6]NAPHTHYRIDINE; CLONIDINE; PROTEIN FOS; TYROSINE 3 MONOOXYGENASE;

ARTICLE; BREATHING RATE; CELL ACTIVITY; CONTROLLED STUDY; HYPOGLOSSAL NERVE; IMMUNOHISTOCHEMISTRY; MALE; MOTONEURON; NERVE CONDUCTION; NONHUMAN; NORADRENERGIC SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANALYSIS OF VARIANCE; ANIMALS; BLOOD PRESSURE; CLONIDINE; ELECTROENCEPHALOGRAPHY; GENE EXPRESSION REGULATION; HYPOGLOSSAL NERVE; ISOQUINOLINES; MALE; NAPHTHYRIDINES; NEURAL INHIBITION; NEURONS; NOREPINEPHRINE; ONCOGENE PROTEINS V-FOS; PONS; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATION; TYROSINE 3-MONOOXYGENASE;

EID: 56149118963     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2008.08.069     Document Type: Article

References (50)

1. Aldes L.D., Shaw B., Chronister R.B., and Haycock J.W. Catecholamine-containing axon terminals in the hypoglossal nucleus of the rat: an immuno-electron microscopic study. Exp Brain Res 81 (1990) 167-178
2. Aldes L.D., Chapman M.E., Chronister R.B., and Haycock J.W. Sources of noradrenergic afferents to the hypoglossal nucleus in the rat. Brain Res Bull 29 (1992) 931-942
3. Al-Zubaidy Z.A., Erickson R.L., and Greer J.J. Serotonergic and noradrenergic effects on respiratory neural discharge in the medullary slice preparation of neonatal rats. Pflügers Arch 431 (1996) 942-949
4. Aston-Jones G., and Bloom F.E. Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle. J Neurosci 1 (1981) 876-886
5. Berridge C.W., Page M.E., Valentino R.J., and Foote S.L. Effects of locus coeruleus inactivation on electroencephalographic activity in neocortex and hippocampus. Neuroscience 55 (1993) 381-393
6. Chamberlin N.L., and Saper C.B. A brainstem network mediating apneic reflexes in the rat. J Neurosci 18 (1998) 6048-6056
7. Chan E., Steenland H.W., Liu H., and Horner R.L. Endogenous excitatory drive modulating respiratory muscle activity across sleep-wake states. Am J Respir Crit Care Med 174 (2006) 1264-1273
8. 2-adrenoceptor antagonist. Arch Pharm Res 23 (2000) 353-359
9. Clark F.M., and Proudfit H.K. The projection of noradrenergic neurons in the A7 catecholamine cell group to the spinal cord in the rat demonstrated by anterograde tracing combined with immunocytochemistry. Brain Res 547 (1991) 279-288
10. Errchidi S., Hilaire G., and Monteau R. Permanent release of noradrenaline modulates respiratory frequency in the newborn rat: an in vitro study. J Physiol (Lond) 429 (1990) 497-510
11. Fenik V., Fenik P., and Kubin L. A simple cuff electrode for nerve recording and stimulation in acute experiments on small animals. J Neurosci Methods 116 (2001) 147-150
12. Fenik V., Marchenko V., Janssen P., Davies R.O., and Kubin L. A5 cells are silenced when REM sleep-like signs are elicited by pontine carbachol. J Appl Physiol 93 (2002) 1448-1456
13. Fenik V.B., Davies R.O., and Kubin L. Noradrenergic, serotonergic and GABAergic antagonists injected together into the XII nucleus abolish the REM sleep-like depression of hypoglossal motoneuronal activity. J Sleep Res 14 (2005) 419-429
14. Fenik V.B., Davies R.O., and Kubin L. REM sleep-like atonia of hypoglossal (XII) motoneurons is caused by loss of noradrenergic and serotonergic inputs. Am J Respir Crit Care Med 172 (2005) 1322-1330
15. Fenik V.B., Ogawa H., Davies R.O., and Kubin L. Carbachol injections into the ventral pontine reticular formation activate locus coeruleus cells in urethane-anesthetized rats. Sleep 28 (2005) 551-559
16. 2-adrenergic agonist, clonidine into the noradrenergic A7 cell region reduce hypoglossal (XII) nerve activity in urethane-anesthetized rats. Sleep 30 Suppl (2007) A19
17. Fritschy J.M., and Grzanna R. Demonstration of two separate descending noradrenergic pathways to the rat spinal cord: Evidence for an intragriseal trajectory of locus coeruleus axons in the superficial layers of the dorsal horn. J Comp Neurol 291 (1990) 553-582
18. Funk G.D., Smith J.C., and Feldman J.L. Development of thyrotropin-releasing hormone and norepinephrine potentiation of inspiratory-related hypoglossal motoneuron discharge in neonatal and juvenile mice in vitro. J Neurophysiol 72 (1994) 2538-2541
19. Hendricks J.C., Petrof B.J., Panckeri K., and Pack A.I. Upper airway dilating muscle hyperactivity during non-rapid eye movement sleep in English bulldogs. Am Rev Respir Dis 148 (1993) 185-194
20. Huangfu D., and Guyenet P.G. Alpha 2-adrenergic autoreceptors in A5 and A6 neurons of neonate rats. Am J Physiol 273 (1997) H2290-H2295
21. Huangfu D.H., Koshiya N., and Guyenet P.G. A5 noradrenergic unit activity and sympathetic nerve discharge in rats. Am J Physiol 261 (1991) R393-R402
22. Ikeda K., Ogura M., Oshima T., Suzuki H., Higano S., Takahashi S., Kurosawa H., Hida W., Matsuoka H., and Takasaka T. Quantitative assessment of the pharyngeal airway by dynamic magnetic resonance imaging in obstructive sleep apnea syndrome. Ann Otol Rhinol Laryngol 110 (2001) 183-189
23. Jiang M., Alheid G.F., Calandriello T., and McCrimmon D.R. Parabrachial-lateral pontine neurons link nociception and breathing. Respir Physiol Neurobiol 143 (2004) 215-233
24. Katz E.S., and White D.P. Genioglossus activity during sleep in normal control subjects and children with obstructive sleep apnea. Am J Respir Crit Care Med 170 (2004) 553-560
25. Kubin L. Carbachol models of REM sleep: recent developments and new directions. Arch Ital Biol 139 (2001) 147-168
26. Kubin L., and Davies R.O. Mechanisms of airway hypotonia. In: Pack A.I. (Ed). Sleep apnea. Pathogenesis, diagnosis, and treatment (2002), Dekker, New York 99-154
27. Lai Y.Y., Kodama T., and Siegel J. Changes in monoamine release in the ventral horn and hypoglossal nucleus linked to pontine inhibition of muscle tone: an in vivo microdialysis study. J Neurosci 21 (2001) 7384-7391
28. 2C-adrenergic receptor immunoreactivity in catecholaminergic neurons in the rat central nervous system. Neuroscience 84 (1998) 1085-1096
29. Li A., and Nattie E. Catecholamine neurones in rats modulate sleep, breathing, central chemoreception and breathing variability. J Physiol (Lond) 570 (2006) 385-396
30. Lu J.W., Fenik V.B., Branconi J.L., Mann G.L., Rukhadze I., and Kubin L. Disinhibition of perifornical hypothalamic neurones activates noradrenergic neurones and blocks pontine carbachol-induced REM sleep-like episodes in rats. J Physiol (Lond) 582 (2007) 52-67
31. Lyons W.E., and Grzanna R. Noradrenergic neurons with divergent projections to the motor trigeminal nucleus and the spinal cord: a double retrograde neuronal labeling study. Neuroscience 26 (1988) 681-693
32. Mezzanotte W.S., Tangel D.J., and White D.P. Waking genioglossal electromyogram in sleep apnea patients versus normal controls (a neuromuscular compensatory mechanism). J Clin Invest 89 (1992) 1571-1579
33. Mezzanotte W.S., Tangel D.J., and White D.P. Influence of sleep onset on upper-airway muscle activity in apnea patients versus normal controls. Am J Respir Crit Care Med 153 (1996) 1880-1887
34. Moore S.D., and Guyenet P.G. Alpha-receptor mediated inhibition of A2 noradrenergic neurons. Brain Res 276 (1983) 188-191
35. Nuseir K., and Proudfit H.K. Bidirectional modulation of nociception by GABA neurons in the dorsolateral pontine tegmentum that tonically inhibit spinally projecting noradrenergic A7 neurons. Neuroscience 96 (2000) 773-783
36. Okabe S., Hida W., Kikuchi Y., Taguchi O., Takishima T., and Shirato K. Upper airway muscle activity during REM and non-REM sleep of patients with obstructive apnea. Chest 106 (1994) 767-773
37. Parkis M.A., Bayliss D.A., and Berger A.J. Actions of norepinephrine on rat hypoglossal motoneurons. J Neurophysiol 74 (1995) 1911-1919
38. Pasquier D.A., Gold M.A., and Jacobowitz D.M. Noradrenergic perikarya (A5-A7, subcoeruleus) projections to the rat cerebellum. Brain Res 196 (1980) 270-275
39. Paxinos G., and Watson C. The rat brain in stereotaxic coordinates, compact 3rd edition (1997), Academic Press, San Diego
40. Pertovaara A. Noradrenergic pain regulation. Prog Neurobiol 80 (2006) 53-83
41. Radulovacki M., Pavlovic S., and Carley D.W. Pontine intertrigeminal region attenuates sleep apneas in rats. Sleep 27 (2004) 383-387
42. Reiner P.B. Clonidine inhibits central noradrenergic neurons in unanesthetized cats. Eur J Pharmacol 115 (1985) 249-257
43. Reiner P.B. Correlational analysis of central noradrenergic neuronal activity and sympathetic tone in behaving cats. Brain Res 378 (1986) 86-96
44. Remmers J.E., DeGroot W.J., Sauerland E.K., and Anch A.M. Pathogenesis of upper airway occlusion during sleep. J Appl Physiol 44 (1978) 931-938
45. 2C-adrenergic receptor-like immunoreactivity in the rat central nervous system. J Comp Neurol 372 (1996) 135-165
46. Rukhadze I., Fenik V.B., Branconi J.L., and Kubin L. Fos expression in pontomedullary catecholaminergic cells following REM sleep-like episodes elicited by pontine carbachol in urethane-anesthetized rats. Neuroscience 152 (2008) 208-222
47. Rukhadze I., and Kubin L. Differential pontomedullary catecholaminergic projections to hypoglossal motor nucleus and viscerosensory nucleus of the solitary tract. J Chem Neuroanat 33 (2007) 23-33
48. Sauerland E.K., and Harper R.M. The human tongue during sleep: electromyographic activity of the genioglossus muscle. Exp Neurol 51 (1976) 160-170
49. Suratt P.M., McTier R.F., and Wilhoit S.C. Upper airway muscle activation is augmented in patients with obstructive sleep apnea compared with that in normal subjects. Am Rev Respir Dis 137 (1988) 889-894
50. 2A-adrenergic receptor-like immunoreactivity in the rat central nervous system. J Comp Neurol 372 (1996) 111-134