A5 cells are silenced when REM sleep-like signs are elicited by pontine carbachol

Journal of Applied Physiology

Volumn 93, Issue 4, 2002, Pages 1448-1456

  Fenik, Victor ^a   Marchenko, Vitaliy ^a   Janssen, Patrick ^a   Davies, Richard O ^a   Kubin, Leszek ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Hypoglossal motoneurons; Norepinephrine; Nucleus of the solitary tract; Pons; Rapid eye movement sleep

Indexed keywords

CARBACHOL; CLONIDINE; NORADRENALIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ARTIFICIAL VENTILATION; CARDIOPULMONARY HEMODYNAMICS; CONTROLLED STUDY; HIPPOCAMPUS; HYPOGLOSSAL NERVE; HYPOTHESIS; LOCUS CERULEUS; MICROINJECTION; MOTONEURON; NERVE CONDUCTION; NONHUMAN; NORADRENALIN RELEASE; NORADRENERGIC NERVE; PONS ANGLE; PRIORITY JOURNAL; RAT; REM SLEEP; SYNAPTIC TRANSMISSION; THALAMUS VENTRAL NUCLEUS; THETA RHYTHM;

EID: 0036786006     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00225.2002     Document Type: Article

References (50)

1. Aldes LD, Chapman ME, Chronister RB, and Haycock JW. Sources of noradrenergic afferents to the hypoglossal nucleus in the rat. Brain Res Bull 29: 931-942, 1992.
2. Aldes LD, Chronister RB, Shelton CI, Haycock JW, Marco LA, and Wong DL. Catecholamine innervation of the rat hypoglossal nucleus. Brain Res Bull 21: 305-312, 1988.
3. Aldes LD, Shaw B, Chronister RB, and Haycock JW. Catecholamine-containing axon terminals in the hypoglossal nucleus of the rat: an immuno-electronmicroscopic study. Exp Brain Res 81: 167-178, 1990.
4. Altschuler SM, Bao X, and Miselis RR. Dendritic architecture of hypoglossal motoneurons projecting to extrinsic tongue musculature in the rat. J Comp Neurol 342: 538-550, 1994.
5. Al-Zubaidy ZA, Erickson RL, and Greer JJ. Serotonergic and noradrenergic effects on respiratory neural discharge in the medullary slice preparation of neonatal rats. Pflügers Arch 431: 942-949, 1996.
6. Aston-Jones G and Bloom FE. Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle. J Neurosci 1: 876-886, 1981.
7. Baghdoyan HA. Cholinergic mechanisms regulating REM sleep. In: Integrating Basic Research and Clinical Practice, edited by Schwartz WJ. Basel: Karger, 1997, p. 88-116.
8. Byrum CE and Guyenet PG. Afferent and efferent connections of the A5 noradrenergic cell group in the rat. J Comp Neurol 261: 529-542, 1987.
9. Clark FM and Proudfit HK. The projections of noradrenergic neurons in the A5 catecholamine cell group to the spinal cord in the rat: anatomical evidence that A5 neurons modulate nociception. Brain Res 616: 200-210, 1993.
10. Coles SK and Dick TE. Neurones in the ventrolateral pons are required for post-hypoxic frequency decline in rats. J Physiol 497:79-94, 1996.
11. Dampney RAL. Functional organization of central pathways regulating the cardiovascular system. Physiol Rev 74: 323-364, 1994.
12. Davies RO and Kubin L. Projection of pulmonary rapidly adapting receptors to the medulla of the cat: an antidromic mapping study. J Physiol 373: 63-86, 1986.
13. Dawid-Milner MS, Lara JP, Gonzaléz-Barón S, and Spyer KM. Respiratory effects of stimulation of cell bodies of the A5 region in the anaesthetised rat. Pflügers Arch 441: 434-443, 2001.
14. Dobbins EG and Feldman JL. Differential innervation of protruder and retractor muscles of the tongue in rat. J Comp Neurol 357: 376-394, 1995.
15. Errchidi S, Hilaire G, and Monteau R. Permanent release of noradrenaline modulates respiratory frequency in the newborn rat: an in vitro study. J Physiol 429: 497-510, 1990.
16. 2A receptor-like protein in the rat. J Comp Neurol 418: 323-345, 2000.
17. Fay RA and Norgren R. Identification of rat brain stem multisynaptic connections to the oral motor nuclei using pseudorabies virus. III. Lingual muscle motor systems. Brain Res Rev 25: 291-311, 1997.
18. Fenik V, Fenik P, and Kubin L. A simple cuff electrode for nerve recording and stimulation in acute experiments on small animals. J Neurosci Methods 116: 147-150, 2001.
19. Fenik V, Janssen P, Davies RO, and Kubin L. Activity of noradrenergic pontine A5 neurons is suppressed during REM sleep-like episodes produced by carbachol in urethane-anesthetized rats (Abstract). Soc Neurosci Abstr 26: 2026, 2000.
20. Fenik V, Marchenko V, Davies RO, and Kubin L. Noradrenergic A5 neurons with axonal projections to the nucleus of the solitary tract (NTS) are silenced during carbachol-induced REM sleep-like episodes in anesthetized rats (Abstract). Soc Neurosci Abstr 27: 836.18, 2001.
21. Fenik V, Ogawa H, Davies RO, and Kubin L. The activity of locus coeruleus neurons is reduced in urethane-anesthetized rats during carbachol-induced episodes of REM sleep-like suppression of upper airway motor tone (Abstract). Soc Neurosci Abstr 25: 2144, 1999.
22. Funk GD, Smith JC, and Feldman JL. Development of thyrotropin-releasing hormone and norepinephrine potentiation of inspiratory-related hypoglossal motoneuron discharge in neonatal and juvenile mice in vitro. J Neurophysiol 72: 2538-2541, 1994.
23. Grzanna R, Chee WK, and Akeyson EW. Noradrenergic projections to brain stem nuclei: evidence for differential projections from noradrenergic subgroups. J Comp Neurol 263: 76-91, 1987.
24. Guyenet PG. Neural structures that mediate sympathoexcitation during hypoxia. Respir Physiol 121: 147-162, 2000.
25. Guyenet PG and Koshiya N. Respiratory-sympathetic integration in the medulla oblongata. In: Central Neural Mechanisms in Cardiovascular Regulation, edited by Kunos G and Ciriello J. Boston, MA: Birkhauser, 1991, vol. 2, p. 226-247.
26. Huangfu DH, Koshiya N, and Guyenet PG. A5 noradrenergic unit activity and sympathetic nerve discharge in rats. Am J Physiol Regul Integr Comp Physiol 261: R393-R402, 1991.
27. Jodkowski JS, Coles SK, and Dick TE. Prolongation in expiration evoked from ventrolateral pons of adult rats. J Appl Physiol 82: 377-381, 1997.
28. i/o protein-mediated mechanisms. J Appl Physiol 80: 2120-2133, 1996.
29. Kishikawa K, Uchida H, Yamamori Y, and Collins JG. Low-threshold neuronal activity of spinal dorsal horn neurons increases during REM sleep in cats: comparison with effects of anesthesia. J Neurophysiol 74: 763-769, 1995.
30. Koshiya N and Guyenet PG. Role of the pons in the carotid sympathetic chemoreflex. Am J Physiol Regul Integr Comp Physiol 267: R508-R518, 1994.
31. Koshiya N and Guyenet PG. A5 noradrenergic neurons and the carotid sympathetic chemoreflex. Am J Physiol Regul Integr Comp Physiol 267: R519-R526, 1994.
32. Koyama Y, Jodo E, and Kayama Y. Sensory responsiveness of "broad-spike" neurons in the laterodorsal tegmental nucleus, locus coeruleus and dorsal raphe of awake rats: implications for cholinergic and monoaminergic neuron-specific responses. Neuroscience 63: 1021-1031, 1994.
33. Kubin L. Carbachol models of REM sleep: recent developments and new directions. Arch Ital Biol 139: 147-168, 2001.
34. Kubin L, Davies RO, and Pack AI. Control of upper airway motoneurons during REM sleep. News Physiol Sci 13: 91-97, 1998.
35. Lai YY, Kodama T, and Siegel J. Changes in monoamine release in the ventral horn and hypoglossal nucleus linked to pontine inhibition of muscle tone: an in vivo microdialysis study. J Neurosci 21: 7384-7391, 2001.
36. Levitt P and Moore RY. Origin and organization of brain stem catecholamine innervation in the rat. J Comp Neurol 186: 505-528, 1979.
37. Marchenko V, Fenik V, Davies RO, and Kubin L. Clonidine microinjections into noradrenergic (NA) A5 and locus coeruleus regions elicit REM sleep-like effects in urethane-anesthetized rats (Abstract). Soc Neurosci Abstr 27: 524.15, 2001.
38. Nicholson C. Diffusion from an injected volurae of a substance in the brain tissue with arbitrary volume fraction and tortuosity. Brain Res 333: 325-329, 1985.
39. Page ME and Valentino RJ. Locus coeruleus activation by physiological challenges. Brain Res 35: 557-560, 1994.
40. Parkis MA, Bayliss DA, and Berger AJ. Actions of norepinephrine on rat hypoglossal motoneurons. J Neurophysiol 74: 1911-1919, 1995.
41. Paxinos G and Watson C. The Rat Brain in Stereotaxic Coordinates (2nd ed.). San Diego, CA: Academic, 1991.
42. Reiner PB. Clonidine inhibits central noradrenergic neurons in unanesthetized cats. Eur J Pharmacol 115: 249-257, 1985.
43. Reiner PB. Correlational analysis of central noradrenergic neuronal activity and sympathetic tone in behaving cats. Brain Res 378: 86-96, 1986.
44. Schreihofer AM, Stornetta RL, and Guyenet PG. Regulation of sympathetic tone and arterial pressure by rostral ventrolateral medulla after depletion of C1 cells in rat. J Physiol 529: 221-236, 2000.
45. Spyer KM. Central nervous mechanisms contributing to cardiovascular control. J Physiol 474: 1-19, 1994.
46. Sun MK. Central neural organization and control of sympathetic nervous system in mammals. Prog Neurobiol 47: 157-233, 1995.
47. Sun MK and Reis DJ. Urethane directly inhibits chemoreflex excitation of medullary vasomotor neurons in rats. Eur J Pharmacol 293: 237-243, 1995.
48. 5 noradrenergic cells which project to the spinal cord dorsal horn are reciprocally connected with the caudal ventrolateral medulla in the rat. Eur J Neurosci 9: 2452-2461, 1997.
49. White SR, Fung SJ, Jackson DA, and Imel KM. Serotonin, norepinephrine and associated neuropeptides: effects on somatic motoneuron excitability. Prog Brain Res 107: 183-199, 1996.
50. Woch G, Ogawa H, Davies RO, and Kubin L. Behavior of hypoglossal inspiratory premotor neurons during the carbachol-induced, REM sleep-like suppression of upper airway motoneurons. Exp Brain Res 130: 508-520, 2000.