Pharmacological Characterization of (10bS)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline Oxalate (YSL-3S) as a New α2-Adrenoceptor Antagonist

Archives of Pharmacal Research

Volumn 23, Issue 4, 2000, Pages 353-359

  Chung, Sung Hyun ^b   Yook, Juwon ^a,b   Min, Byung Jun ^a,c   Lee, Jae Yeol ^a   Lee, Yong Sup ^a   Jin, Changbae ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Kyung Hee University   (South Korea)

^c Hankuk University of Foreign Studies   (South Korea)

Author keywords

Cerebral cortex; Clonidine; Depression; Vas deferens; Yohimbine; YSL 3S; 3H Cytisine; 3H Rauwolscine; 2 Adrenoceptors

Indexed keywords

1,2,3,5,6,10B HEXAHYDROPYRROLO(2,1 A)ISOQUINOLINE OXALATE; 1,2,3,5,6,10B-HEXAHYDROPYRROLO(2,1-A)ISOQUINOLINE OXALATE; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ISOQUINOLINE DERIVATIVE; OXALIC ACID DERIVATIVE; YOHIMBINE;

ANIMAL; ARTICLE; DOSE RESPONSE; DRUG ANTAGONISM; MALE; RADIOASSAY; RAT; SPRAGUE DAWLEY RAT;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ISOQUINOLINES; MALE; OXALATES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-2; YOHIMBINE;

EID: 0034251906     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02975447     Document Type: Article

References (21)

1. 50) of an enzymatic reaction. Biochem. Pharmacol., 22, 3099-3108 (1973).
2. Doxey, J. C., Smith, C. F. C. and Walker, J. M., Selectivity of blocking agents for pre- and postsynaptic a-adrenoceptors. Br. J. Pharmacol., 60, 91-96 (1977).
3. 2 antagonist. Drug Development Res., 28, 56-64 (1993).
4. 3H]DOPA in various regions of the brain. J. Neurochem., 13, 655-669 (1966).
5. 2-adrenoreceptor. Pharmacol. Rev., 35, 143-180 (1983).
6. Hancock, A. A., Buckner, S. A., Giardina, W. J., Brune, M. E., Lee, J. Y., Morse, P. A., Oheim, K. W., Stanisic, D. S., Warner, R. B., Kerkman, D. J. and DeBernardis, J. F., Preclinical pharmacological actions of (±)-(1′R*,3R*)-3-phenyl-1-[(1′,2′,3′, 4′-tetrahydro-5′,6′-methylene-dioxy-1′-naphthalenyl) methyl] pyrrolidine methanesulfonate (ABT-200), a potential antidepressant agent that antagonizes alpha-2 adrenergic receptors and inhibits the neuronal uptake of norepinephrine. J. Pharmacol. Exp. Ther., 272, 1160-1169 (1995).
7. Hedler, M., Stamm, G., Weitzell, R. and Starke, K., Functional characterization of central a-adrenoceptors by yohimbine diastereoisomers. Eur. J. Pharmacol., 70, 43-49 (1981).
8. L-tartaric acid. J. Org. Chem., 60, 7149-7152 (1995).
9. Lee, Y. S., Kim, S. H., Jung, S. H., Lee, S. J. and Park, H., Studies on the site-selective N-acyliminium ion cyclization: synthesis of (±)-glochidine and (±)-glochidicine. Heterocydes, 37, 303-309 (1994).
10. Lefkowitz, R. J., Huffman, B. B. and Taylor, R, Neurotransmission: The autonomic and somatic motor nervous systems, In Hardman, J. G., Limbird, L. E., Molinoff, P. B., Ruddon, R. W. and Gilman, A. G. (Eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. McGraw-Hill, Singapore, pp. 105-139, 1996.
11. Leitch, I. M., Rawlow, A., King, R. G., Boura, A. L., Bremner, J. B. and Browne, E. J., The action of 1,2,3,5,6,11b-hexahydro-[1]-benzothieno[3,2-g]indolizine hydrochloride (ADT-16) on peripheral and central responses mediated by 5-hydroxytryptaminergic and adrenergic systems of the rat. J. Pharm. Pharmacol., 46 (10), 820-825 (1994).
12. Lowry, O. N. and Rosebrough, N. J., Protein measurement with Folin phenol reagent. J. Biol. Chem., 193, 265-275 (1951).
13. 3H]Cytisine binding to nicotinic cholinergic receptors in brain. Molecular Pharmacology, 39, 9-12 (1991).
14. 2-adrenergic receptors. Eur. J. Pharmacol., 76, 461-464 (1981).
15. Pinder, R. M. and Wieringa, J. H., Third-generation antidepressants. Medicinal Research Reviews, 13, 259-325 (1993).
16. Prous, J. R., Antidepressants, In Prous, J. R. (Ed.). The Year's Drug News. Prous Science, Barcelona, pp. 53-60, 1995.
17. Richelson, E., Pharmacology of antidepressant. Psychopathol., 20 (suppl 1), 1-12 (1987).
18. 2. A new scale for the measurement of drug antagonism. Br. J. Pharmacol., 2, 189-206 (1947).
19. 2 and receptor differentiation: A statistical analysis of competitive antagonism. Life Sci., 25, 637-654 (1979).
20. Weich, N. L. and Ursillo, R. C., Acceleration of despiramine-induced decrease of rat corticocerebral β-adrenergic receptors by yohimbine. Commun. Psychopharmacol. 4, 95-100 (1980).
21. Zukin, S. R., Young, A. B. and Snyder, S. H., Gamma-aminobutyric acid binding to receptor sites in the rat central nervous system. Proc. Natl. Acad. Sci. USA, 71, 4802-4807 (1974).