Retinal p75 and bax overexpression is associated with retinal ganglion cells apoptosis in a rat model of glaucoma

Graefe's Archive for Clinical and Experimental Ophthalmology

Volumn 246, Issue 12, 2008, Pages 1743-1749

  Coassin, Marco ^a   Lambiase, Alessandro ^a   Sposato, Valentina ^b   Micera, Alessandra ^a,c   Bonini, Stefano ^a   Aloe, Luigi ^b  

^a UNIVERSITY CAMPUS BIO MEDICO   (Italy)

^b CNR   (Italy)

^c IRCCS FONDAZIONE BIETTI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

NERVE GROWTH FACTOR; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P75; TROPOMYOSIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; DISEASE COURSE; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GLAUCOMA; INTRAOCULAR HYPERTENSION; INTRAOCULAR PRESSURE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RETINA GANGLION CELL; UPREGULATION;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL COUNT; DISEASE MODELS, ANIMAL; GLAUCOMA; INTRAOCULAR PRESSURE; MALE; NERVE GROWTH FACTOR; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, INBRED BN; RECEPTOR, TRKA; RECEPTORS, NERVE GROWTH FACTOR; RETINA; RETINAL GANGLION CELLS; RNA, MESSENGER; TIME FACTORS; UP-REGULATION;

EID: 56049120307     PISSN: 0721832X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00417-008-0913-5     Document Type: Article

References (29)

1. Quigley HA, Dunkelberger GR, Green WR (1989) Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma. Am J Ophthalmol 107:453-464
2. Pease ME, McKinnon SJ, Quigley HA, Kerrigan-Baumrind LA, Zack DJ (2000) Obstructed axonal transport of BDNF and its receptor TrkB in experimental glaucoma. Invest Ophthalmol Vis Sci 41:764-774
3. Hefti F (1994) Neurotrophic factor therapy for nervous system degenerative diseases. J Neurobiol 25:1418-1435, doi: 10.1002/ neu.480251109
4. Levi-Montalcini R (1987) The nerve growth factor 35 years later. Science 237:1154-1162, doi: 10.1126/science.3306916
5. Saragovi HU, Zheng W, Maliartchouk S, DiGugliemo GM, Mawal YR, Kamen A et al (1998) A TrkA-selective, fast internalizing nerve growth factor-antibody complex induces trophic but not neuritogenic signals. J Biol Chem 273:34933-34940, doi: 10.1074/jbc.273.52.34933
6. Chao M, Casaccia-Bonnefil P, Carter B, Chittka A, Kong H, Yoon SO (1998) Neurotrophin receptors: Mediators of life and death. Brain Res Brain Res Rev 26:295-301, doi: 10.1016/S0165-0173(97)00036-2
7. Casaccia-Bonnefil P, Gu C, Chao MV (1999) Neurotrophins in cell survival/ death decisions. Adv Exp Med Biol 468:275-282
8. Carmignoto G, Maffei L, Candeo P, Canella R, Comelli C (1989) Effect of NGF on the survival of rat retinal ganglion cells following optic nerve section. J Neurosci 9:1263-1272
9. Siliprandi R, Canella R, Carmignoto G (1993) Nerve growth factor promotes functional recovery of retinal ganglion cells after ischemia. Invest Ophthalmol Vis Sci 34:3232-3245
10. Lambiase A, Centofanti M, Micera A, Manni GL, Mattei E, De Gregorio A et al (1997) Nerve growth factor (NGF) reduces and NGF antibody exacerbates retinal damage induced in rabbit by experimental ocular hypertension. Graefes Arch Clin Exp Ophthalmol 235:780-785, doi: 10.1007/BF02332863
11. Cui Q, Lu Q, So KF, Yip HK (1999) CNTF, not other trophic factors, promotes axonal regeneration of axotomized retinal ganglion cells in adult hamsters. Invest Ophthalmol Vis Sci 40:760-766
12. Shi Z, Birman E, Saragovi HU (2007) Neurotrophic rationale in glaucoma: A TrkA agonist, but not NGF or a p75 antagonist, protects retinal ganglion cells in vivo. Dev Neurobiol 67:884-894, doi: 10.1002/dneu.20360
13. Carmignoto G, Comelli MC, Candeo P, Cavicchioli L, Yan Q, Merighi A et al (1991) Expression of NGF receptor and NGF receptor mRNA in the developing and adult rat retina. Exp Neurol 111:302-311, doi: 10.1016/ 0014-4886(91)90097-V
14. Rudzinski M, Wong TP, Saragovi HU (2004) Changes in retinal expression of neurotrophins and neurotrophin receptors induced by ocular hypertension. J Neurobiol 58:341-354, doi: 10.1002/neu.10293
15. Morrison JC, Moore CG, Deppmeier LM, Gold BG, Meshul CK, Johnson EC (1997) A rat model of chronic pressure-induced optic nerve damage. Exp Eye Res 64:85-96, doi: 10.1006/exer.1996.0184
16. Morrison JC, Johnson EC, Cepurna W, Jia L (2005) Understanding mechanisms of pressure-induced optic nerve damage. Prog Retin Eye Res 24:217-240, doi: 10.1016/j.preteyeres.2004.08.003
17. Moore CG, Epley D, Milne ST, Morrison JC (1995) Long-term non-invasive measurement of intraocular pressure in the rat eye. Curr Eye Res 14:711-717, doi: 10.3109/02713689508998499
18. Jia L, Cepurna WO, Johnson EC, Morrison JC (2000) Effect of general anesthetics on IOP in rats with experimental aqueous outflow obstruction. Invest Ophthalmol Vis Sci 41:3415-3419
19. Lambiase A, Bonini S, Micera A, Rama P, Bonini S, Aloe L (1998) Expression of nerve growth factor receptors on the ocular surface in healthy subjects and during manifestation of inflammatory diseases. Invest Ophthalmol Vis Sci 39:1272-1275
20. Johnson EC, Deppmeier LM, Wentzien SK, Hsu I, Morrison JC (2000) Chronology of optic nerve head and retinal responses to elevated intraocular pressure. Invest Ophthalmol Vis Sci 41:431-442
21. Pfaffl MW, Horgan GW, Dempfle L (2002) Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 30:e36, doi: 10.1093/nar/30.9.e36
22. Aguayo AJ, Clarke DB, Jelsma TN, Kittlerova P, Friedman HC, Bray GM (1996) Effects of neurotrophins on the survival and regrowth of injured retinal neurons. Ciba Found Symp 196:135-144 discussion 144-148
23. Yoon SO, Casaccia-Bonnefil P, Carter B, Chao MV (1998) Competitive signaling between TrkA and p75 nerve growth factor receptors determines cell survival. J Neurosci 18:3273-3281
24. Majdan M, Walsh GS, Aloyz R, Miller FD (2001) TrkA mediates developmental sympathetic neuron survival in vivo by silencing an ongoing p75NTR-mediated death signal. J Cell Biol 155:1275-1285, doi: 10.1083/jcb.200110017
25. Nickells RW (1999) Apoptosis of retinal ganglion cells in glaucoma: An update of the molecular pathways involved in cell death. Surv Ophthalmol 43(Suppl 1):S151-S161, doi: 10.1016/S0039-6257(99)00029-6
26. la Sala A, Corinti S, Federici M, Saragovi HU, Girolomoni G (2000) Ligand activation of nerve growth factor receptor TrkA protects monocytes from apoptosis. J Leukoc Biol 68:104-110
27. Tabassum A, Khwaja F, Djakiew D (2003) The p75(NTR) tumor suppressor induces caspase-mediated apoptosis in bladder tumor cells. Int J Cancer 105:47-52, doi: 10.1002/ijc.11038
28. Troy CM, Friedman JE, Friedman WJ (2002) Mechanisms of p75-mediated death of hippocampal neurons. Role of caspases. J Biol Chem 277:34295-34302, doi: 10.1074/jbc.M205167200
29. Fortune B, Bui BV, Morrison JC, Johnson EC, Dong J, Cepurna WO et al (2004) Selective ganglion cell functional loss in rats with experimental glaucoma. Invest Ophthalmol Vis Sci 45:1854-1862, doi: 10.1167/ iovs.03-1411