Selective effects of cyclosporine A on Th2-skewed dendritic cells matured with viral-like stimulus by means of toll-like receptors

Transplantation

Volumn 86, Issue 6, 2008, Pages 880-884

  Abdul, Mubashira ^a   Charron, Dominique ^a   Haziot, Alain ^a  

^a INSERM   (France)

Author keywords

Dendritic cell differentiation; Immunosuppression; Infection; T cell polarization

Indexed keywords

CYCLOSPORIN A; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; POLYINOSINIC POLYCYTIDYLIC ACID; TOLL LIKE RECEPTOR; CYCLOSPORIN; CYTOKINE; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 4;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; DRUG EFFECT; INTERNALIZATION; LYMPHOCYTE PROLIFERATION; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TH2 CELL; CYTOLOGY; HUMAN; IMMUNOLOGY; PHYSIOLOGY;

CELL DIFFERENTIATION; CYCLOSPORINE; CYTOKINES; DENDRITIC CELLS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-4; LIPOPOLYSACCHARIDES; POLY I-C; TH2 CELLS; TOLL-LIKE RECEPTORS;

EID: 56049108825     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181861f1d     Document Type: Article

References (44)

1. Riddell SR, Appelbaum FR. Graft-versus-host disease: A surge of developments. PLoS Med 2007; 4: e198.
2. ShlomchikWD, Couzens MS, TangCB, et al. Prevention of graft versus host disease by inactivation of host antigen-presenting cells. Science 1999; 285: 412.
3. Ferrara JL, Reddy P. Pathophysiology of graft-versus-host disease. Semin Hematol 2006; 43: 3.
4. Fowler DH, Gress RE. Graft-vs.-host disease as a Th1-type process: regulation by Th2-type cells. In: Ferrara JLM, Cooke KR, Deeg HJ, eds. Graft-vs.-host disease. New York, Marcel Dekker 2005, p 59.
5. Barbara JA, Turvey SE, Kingsley CI, et al. Islet allograft rejection can be mediated by CD4+, alloantigen experienced, direct pathway T cells of TH1 and TH2 cytokine phenotype. Transplantation 2000; 70: 1641.
6. Wang H, Hosiawa KA, Min W, et al. Cytokines regulate the pattern of rejection and susceptibility to cyclosporine therapy in different mouse recipient strains after cardiac allografting. J Immunol 2003; 171: 3823.
7. Fowler DH, Kurasawa K, Smith R, et al. Donor CD4-enriched cells of Th2 cytokine phenotype regulate graft-versus-host disease without impairing allogeneic engraftment in sublethally irradiated mice. Blood 1994; 84: 3540.
8. Arpinati M, Green CL, Heimfeld S, Heuser JE, Anasetti C. Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells. Blood 2000; 95: 2484.
9. Reddy P, Teshima T, Hildebrandt G, et al. Pretreatment of donors with interleukin-18 attenuates acute graft-versus-host disease via STAT6 and preserves graft-versus-leukemia effects. Blood 2003; 101: 2877.
10. Antin JH, Lee SJ, Neuberg D, et al. A phase I/II double-blind, placebo-controlled study of recombinant human interleukin-11 for mucositis and acute GVHD prevention in allogeneic stem cell transplantation. Bone Marrow Transplant 2002; 29: 373.
11. Hashimoto D, AsakuraS, MiyakeS, et al. Stimulation ofhostNKT cells by synthetic glycolipid regulates acute graft-versus-host disease by inducing Th2 polarization of donor T cells. J Immunol 2005; 174: 551.
12. Foley JE, Jung U, Miera A, et al. Ex vivo rapamycin generates donor Th2 cells that potently inhibit graft-versus-host disease and graft-versus-tumor effects via an IL-4-dependent mechanism. J Immunol 2005; 175:5732.
13. Nikolic B, Lee S, Bronson RT, et al. Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets. J Clin Invest 2000; 105: 1289.
14. Liu J, Anderson BE, Robert ME, et al. Selective T-cell subset ablation demonstrates a role for T1 and T2 cells in ongoing acute graft-versus-host disease: A model system for the reversal of disease. Blood 2001; 98: 3367.
15. Singh N. Infectious complications in organ transplant recipients with the use of calcineurin-inhibitor agent-based immunosuppressive regimens. Curr Opin Infect Dis 2005; 18: 342.
16. Rubin RH, Ikonen T, Gummert JF, et al. The therapeutic prescription for the organ transplant recipient: The linkage of immunosuppression and antimicrobial strategies. Transpl Infect Dis 1999; 1: 29.
17. McHugh SM, Rifkin IR, Deighton J, et al. The immunosuppressive drug thalidomide induces T helper cell type 2 (Th2) and concomitantly inhibits Th1 cytokine production in mitogen- and antigen-stimulated human peripheral blood mononuclear cell cultures. Clin Exp Immunol 1995; 99:160.
18. Farrell AM, Antrobus P, Simpson D, et al. A rapid flow cytometric assay to detect CD4+ andCD8+ T-helper (Th) 0, Th1 and Th2 cells in whole blood and its application to study cytokine levels in atopic dermatitis before and after cyclosporin therapy. Br J Dermatol 2001; 144: 24.
19. Muller KM, Jaunin F, Masouye I, et al. Th2 cells mediate IL-4-dependent local tissue inflammation. J Immunol 1993; 150: 5576.
20. Yamashita M, Katsumata M, Iwashima M, et al. T cell receptor-induced calcineurin activation regulates T helper type 2 cell development by modifying the interleukin 4 receptor signaling complex. J Exp Med 2000; 191: 1869.
21. MatsudaS, Koyasu S. Mechanisms of action of cyclosporine. Immuno-pharmacology 2000; 47: 119.
22. Ho S, Clipstone N, Timmermann L, et al. The mechanism of action of cyclosporin A and FK506. Clin Immunol Immunopathol 1996; 80: S40.
23. Dobbeling U. The effects of cyclosporin A on V(D)J recombination activity. Scand J Immunol 1997; 45: 494.
24. Yamaguchi Y, Goto M, Makino Y, et al. Effect of cyclosporine on the distribution of macrophage phenotypes in the rat hepatic allograft. Transplant Proc 1993; 25: 1796.
25. Lagaraine C, Lebranchu Y. Effects of immunosuppressive drugs on dendritic cells and tolerance induction. Transplantation 2003; 75: 37S.
26. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998; 392: 245.
27. Kaisho T, Akira S. Toll-like receptor function and signaling. J Allergy Clin Immunol 2006; 117: 979.
28. Shortman K, Liu YJ. Mouse and human dendritic cell subtypes. Nat Rev Immunol 2002; 2: 151.
29. Romagnani S. T-cell subsets (Th1 versus Th2). Ann Allergy Asthma Immunol 2000; 85: 9.
30. Szabo G, Gavala C, Mandrekar P. Tacrolimus and cyclosporine A inhibit allostimulatory capacity and cytokine production of human myeloid dendritic cells. J InvestigMed 2001; 49: 442.
31. Lee JI, Ganster RW, Geller DA, et al. Cyclosporine A inhibits the expression of costimulatory molecules on in vitro-generated dendritic cells: Association with reduced nuclear translocation of nuclear factor kappa B. Transplantation 1999; 68: 1255.
32. Duperrier K, Farre A, Bienvenu J, et al. Cyclosporin A inhibits dendritic cell maturation promoted by TNF-alpha or LPS but not by double-stranded RNA or CD40L. J Leukoc Biol 2002; 72: 953.
33. Woltman AM, de Fijter JW, Kamerling SW, et al. The effect of calcineurin inhibitors and corticosteroids on the differentiation of human dendritic cells. Eur J Immunol 2000; 30: 1807.
34. Tajima K, Amakawa R, Ito T, et al. Immunomodulatory effects of cyclosporin A on human peripheral blood dendritic cell subsets. Immunology 2003; 108: 321.
35. Xu S, Koski GK, Faries M, et al. Rapid high efficiency sensitization of CD8 + T cells to tumor antigens by dendritic cells leads to enhanced functional avidity and direct tumor recognition through an IL-12-dependent mechanism. J Immunol 2003; 171:2251.
36. Manthey CL, Vogel SN. Elimination of trace endotoxin protein from rough chemotype LPS. J Endotoxin Res 1994; 1: 84.
37. Wood KJ, Sakaguchi S. Regulatory T cells in transplantation tolerance. Nature Rev Immunol 2003; 3: 199.
38. Opelz G. Efficacy of rejection prophylaxis with OKT3 in renal transplantation. Collaborative Transplant Study. Transplantation 1995; 60: 1220.
39. + regulatory T cells. Blood 2006; 107: 1018.
40. + regulatory T-cell function by calcineurin-dependent interleukin-2 production. Blood 2006; 108: 390.
41. Vezzio N, Sarfati M, Yang LP, et al. Human Th2-like cell clones induce IL-12 production by dendritic cells and may express several cytokine profiles. Int Immunol 1996; 8: 1963.
42. Kang YJ, Kusler B, Otsuka M, et al. Calcineurin negatively regulates TLR-mediated activation pathways. J Immunol 2007; 179: 4598.
43. Lyons AB, Parish CR. Determination of lymphocyte division by flow cytometry. J Immunol Methods 1994; 171: 131.
44. Wells AD, Gudmundsdottir H, Turka LA. Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response. J Clin Invest 1997; 100: 3173.