Function-oriented synthesis: Biological evaluation of laulimalide analogues derived from a last step cross metathesis diversification strategy

Molecular Pharmaceutics

Volumn 5, Issue 5, 2008, Pages 829-838

  Mooberry, Susan L ^a   Hilinski, Michael K ^b   Clark, Erin A ^a   Wender, Paul A ^b  

^a SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

Antimitotics; Laulimalide; Laulimalide analogues; Metathesis; Microtubule stabilizers; Synthetic chemistry

Indexed keywords

ANTINEOPLASTIC AGENT; LAULIMALIDE; LAULIMALIDE DERIVATIVE; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; IMMUNOBLOTTING; MICROTUBULE; MITOSIS INHIBITION; MITOSIS SPINDLE; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REACTION ANALYSIS;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FLOW CYTOMETRY; HUMANS; INHIBITORY CONCENTRATION 50; MACROLIDES; MICROTUBULES; MITOTIC SPINDLE APPARATUS; MOLECULAR STRUCTURE; PROTO-ONCOGENE PROTEINS C-BCL-2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 56049100275     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp800043n     Document Type: Article

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