Interlaboratory comparison of short-term carcinogenicity studies using CB6F1-rasH2 transgenic mice

Toxicologic Pathology

Volumn 31, Issue 2, 2003, Pages 191-199

  Takaoka, Masaya ^a   Sehata, Shinya ^a   Maejima, Takanori ^a   Imai, Toshio ^b   Torii, Mikinori ^c   Satoh, Hiroshi ^a   Toyosawa, Kaoru ^d   Tanakamaru, Zen yo ^e   Adachi, Tamiko ^f   Hisada, Shigeru ^g   Ueda, Makoto ^h   Ogasawara, Hiroyuki ⁱ   Matsumoto, Masahiro ^j   Kobayashi, Kiyoshi ^f   Mutai, Mamoru ^f   Usui, Toshimi ^k  

^a DAIICHI SANKYO CO   (Japan)

^b EISAI CO LTD   (Japan)

^c SHIONOGI AND CO LTD   (Japan)

^d DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^e TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^f MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

^g Grelan Pharmaceutical Co Ltd   (Japan)

^h NIPPON SHINYAKU CO LTD   (Japan)

ⁱ Department of Pharmacokinetics   (Japan)

^j ASTELLAS PHARMA INC   (Japan)

^k CENTRAL INSTITUTE FOR EXPERIMENTAL ANIMALS   (Japan)

more..

Author keywords

Human prototype c Ha ras gene; ILSI HESI international collaborative project; N methyl N nitrosourea; RasH2 Tg mouse; Short term carcinogenicity testing

Indexed keywords

AMPICILLIN; CHLOROFORM; CHLORPROMAZINE; CLOFIBRATE; CYCLOPHOSPHAMIDE; DIETHYLSTILBESTROL; METHYLNITROSOUREA; ORCIPRENALINE; PHENOBARBITAL; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; RESERPINE; SULFAMETHOXAZOLE;

ANGIOSARCOMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANIMAL USE; ARTICLE; CARCINOGEN TESTING; CARCINOGENICITY; CONTROLLED STUDY; HEMANGIOMA; INCIDENCE; LABORATORY; LUNG ADENOMA; MORTALITY; MOUSE; NONHUMAN; ONCOGENE H RAS; PAPILLOMA VIRUS; PRIORITY JOURNAL; SPLEEN TUMOR; SQUAMOUS CELL CARCINOMA; STOMACH CARCINOMA; STOMACH LYMPHOMA; TRANSGENIC MOUSE; WEIGHT GAIN;

ACADEMIES AND INSTITUTES; ALKYLATING AGENTS; ANIMALS; BODY WEIGHT; CARCINOGENICITY TESTS; CARCINOGENS; FEMALE; GENES, RAS; HUMANS; INTERNATIONAL COOPERATION; LABORATORIES; MALE; METHYLNITROSOUREA; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; NEOPLASMS, EXPERIMENTAL; REPRODUCIBILITY OF RESULTS; TIME FACTORS; XENOBIOTICS;

ANIMALIA; MUS MUSCULUS; PAPILLOMAVIRUS;

EID: 0037351641     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1080/01926230309812     Document Type: Article

References (20)

1. Boorman GA, Maronpot RR, Eustis SL (1994). Rodent carcinogenicity bioassay: Past, present, future. Toxicol Pathol 22: 105-111.
2. Butterworth BE, Conolly RB, Morgan KT (1995). A strategy for establishing mode of action of chemical carcinogens as a guide for approaches to risk assessments. Cancer Lett 93: 129-146.
3. Davies TS, Monro A (1995). Marketed human pharmaceuticals reported to be tumorigenic in rodents. J Am Coll Toxicol 14: 90-107.
4. Gulezian D, Jacobson-Kram D, McCullough CB, Olson H, Recio L, Robinson D, Storer R, Tennant R, Ward JM, Neumann DA (2000). Use of transgenic animals for carcinogenicity testing: Considerations and implications for risk assessment. Toxicol Pathol 28: 482-499.
5. International Agency for Research on Cancer (1978). N-Nitroso-N-methylurea. In: IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Vol. 17, Some N-Nitroso Compounds. International Agency for Research on Cancer, Lyon, France, pp 227-255.
6. International Conference on Harmonization (1998). Guidance on testing for carcinogenicity of pharmaceuticals. Fed Regist 63: 8983-8986.
7. Katsutani N, Sekido T, Aoki T, Sagami F (2000). Hepatic drug metabolizing enzymes induced by clofibrate in rasH2 mice. Toxicology Lett 115: 223-229.
8. Maronpot RR, Mitsumori K, Mann P, Takaoka M, Yamamoto S, Usui T, Okamiya H, Nishikawa S, Nomura T (2000). Interlaboratory comparison of the CB6F1-Tg rasH2 rapid carcinogenicity testing model. Toxicology 146: 149-159.
9. Maruyama C, Tomisawa M, Wakana S, Yamazaki H, Kijima H, Suemizu H, Ohnishi Y, Urano K, Hioki K, Usui T, Nakamura M, Tsuchida T, Mitsumori K, Nomura T, Tamaoki N, Ueyama Y (2001). Overexpression of human H-ras transgene is responsible for tumors induced by chemical carcinogens in mice. Oncol Rep 8: 233-237.
10. Mitsumori K, Koizumi H, Nomura T, Yamamoto S (1998). Pathological features of spontaneous and induced tumors in transgenic mice carrying a human prototype c-Ha-ras gene used for six-month carcinogenicity studies. Toxicol Pathol 26: 520-531.
11. Ohnishi Y, Arai T, Koshirakawa M, Horii N, Nakajo S, Urano K, Usui T, Tamaoki N, Ueyama Y (2001). Induction of drug metabolism-related enzymes by methylcholanthrene and phenobarbital in transgenic mice carrying human prototype c-Ha-ras gene and their wild type littermates. Exp Anim 50: 33-39.
12. Robinson DE, MacDonald JS (2001). Background and framework for ILSI's collaborative evaluation program on alternative models for carcinogenicity assessment. Toxicol Pathol 29 (Suppl): 13-19.
13. Saitoh A, Kimura M, Takahashi R, Yokoyama M, Nomura T, Izawa M, Sekiya T, Nishimura S, Katsuki M (1990). Most tumors in transgenic mice with human c-Ha-ras gene contained somatically activated transgenes. Oncogene 5: 1195-1200.
14. Tamaoki N (2001). The rasH2 transgenic mouse: Nature of the model and mechanistic studies on tumorigenesis. Toxicol Pathol 29 (Suppl): 81-89.
15. Tennant RW, French JE, Spalding JW (1995). Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models. Environ Health Perspect 103: 942-950.
16. Terracini B, Testa MC (1970). Carcinogenicity of a single administration of N-nitrosomethylurea: A comparison between new-born and 5-week-old mice and rats. Br J Cancer 24: 588-598.
17. Usui T, Mutai M, Hisada S, Takaoka M, Soper KA, McCullough B, Alden C (2001). CB6F1-rasH2 mouse: Overview of available data. Toxicol Pathol 29 (Suppl): 90-108.
18. Ward JM, Shibata M, Devor DE (1996). Emerging issues in mouse liver carcinogenesis. Toxicol Pathol 24: 129-137.
19. Yamamoto S, Hayashi Y, Mitsumori K, Nomura T (1997). Rapid carcinogenicity testing system with transgenic mice harboring human prototype c-HRAS Gene. Lab Anim Sci 47: 121-126.
20. Yamamoto S, Mitsumori K, Kodama Y, Matsunuma N, Manabe S, Okamiya H, Suzuki H, Fukuda T, Sakamaki Y, Sunaga M, Nomura G, Hioki K, Wakana S, Nomura T, Hayashi Y (1996). Rapid induction of more malignant tumors by various genotoxic carcinogens in transgenic mice harboring a human prototype c-Ha-ras gene than in control non-transgenic mice. Carcinogenesis 17: 2455-2461.