Oral phosphatidylcholine pretreatment decreases ischemia-reperfusion induced methane generation and the inflammatory response in the small intestine

Shock

Volumn 30, Issue 5, 2008, Pages 596-602

  Ghyczy, Miklós ^a   Torday, Csilia ^b   Kaszaki, József ^b   Szabó, Andrea ^b   Czóbel, Miklós ^b   Boros, Mihály ^b  

^a University of Szeged ^*

^b UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Breath methane; Choline metabolites; Dog; Leukocyte; Mucosa; Oxidoreductive stress; pH

Indexed keywords

CHOLINE; METHANE; MYELOPEROXIDASE; PHOSPHATIDYLCHOLINE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBON DIOXIDE TENSION; CONTROLLED STUDY; DIETARY INTAKE; DOG; ENZYME ACTIVITY; HEMODYNAMICS; INFLAMMATION; INTESTINE BIOPSY; INTESTINE ISCHEMIA; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATIVE STRESS; PH MEASUREMENT; REOXYGENATION; REPERFUSION INJURY;

ADMINISTRATION, ORAL; ANIMALS; DOGS; HEMODYNAMICS; HYDROGEN-ION CONCENTRATION; INTESTINAL MUCOSA; INTESTINE, SMALL; ISCHEMIC PRECONDITIONING; METHANE; PHOSPHATIDYLCHOLINES; REPERFUSION INJURY; SUPEROXIDES;

EID: 55949116151     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/SHK.0b013e31816f204a     Document Type: Article

References (38)

1. Carden DL, Granger DN: Pathophysiology of ischaemia-reperfusion injury. J Pathol 190:255-266, 2000.
2. Stallion A, Kou TD, Latifi SQ, Miller KA, Dahms BB, Dudgeon DL, Levine AD: Ischemia/reperfusion: a clinically relevant model of intestinal injury yielding systemic inflammation. J Pediatr Surg 40:470-477, 2005.
3. Boras M: Microcirculatory dysfunction during intestinal ischemia-reperfusion. Acta Physiol Hung 90:263-279, 2003.
4. Mallick IH, Yang W, Winslet MC, Seifalian AM: Ischemia-reperfusion injury of the intestine and protective strategies against injury. Dig Dis Sci 49: 1359-1377, 2004.
5. Massberg S, Messmer K: The nature of ischemia/reperfusion injury. Transplant Proc 30:4217-4223, 1998.
6. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J: Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39:44-84, 2007.
7. Duan J, Karmazyn M: Protection of the reperfused ischemic isolated rat heart by phosphatidylcholine. J Cardiol Pharm 15:163-171, 1990.
8. Duan J, Moffat MP: Protective effects of phosphatidylcholine against mechanisms of ischemia and reperfusion-induced arrhythmias in isolated guinea pig ventricular tissues. Naunyn-Schmiedebergs Arch Pharmacol 342: 342-348, 1990.
9. el-Hariri LM, Marriott C, Martin GP: The mitigating effects of phosphatidylcholines on bile salt- and lysophosphatidylcholine-induced membrane damage. J Pharm Pharmacol 44:651-654, 1992.
10. Eros G, Kaszaki J, Czobel M, Boros M: Systemic phosphatidylcholine pretreatment protects canine esophageal mucosa during acute experimental biliary reflux. World J Gastroenterol 12:271-279, 2006.
11. Demirbilek S, Aydin G, Yucesan S, Vural H, Bitiren M: Polyunsaturated phosphatidylcholine lowers collagen deposition in a rat model of corrosive esophageal burn. Eur J Pediatr Surg 12:8-12, 2002.
12. Treede I, Braun A, Sparla R, Kuhnel M, Giese T, Turner JR, Anes E, Kulaksiz H, Fullekrug J, Stremmel W, et al.: Anti-inflammatory effects of phosphatidylcholine. J Biol Chem 282:27155-27164, 2007.
13. Ghyczy M, Boros M: Electrophilic methyl groups present in the diet ameliorate pathological states induced by reductive and oxidative stress: a hypothesis. Br J Nutr 85:409-414, 2001.
14. Ghyczy M, Torday C, Boras M: Simultaneous generation of methane, carbon dioxide, and carbon monoxide from choline and ascorbic acid: a defensive mechanism against reductive stress? FASEB J 17:1124-1126, 2003.
15. Ghyczy M, Torday C, Kaszaki J, Szabo A, Czobel M, Boras M: Hypoxia-induced generation of methane in mitochondria and eukaryotic cells. An alternative approach to methanogenesis. Cell Physiol Biochem 21:251-258, 2008.
16. Fiddian-Green RG: Studies in splanchnic ischemia and multiple organ failure. In: Marston A, Bulkley GB, Fiddian-Green RG, Haglund U, eds. Splanchnic Ischemia and Multiple Organ Failure. London, England: Mosby Co. 1989, 349-362.
17. Creteur J, De Backer D, Sakr Y, Koch M, Vincent JL: Sublingual capnometry tracks microcirculatory changes in septic patients. Intensive Care Med 32: 516-523, 2006.
18. Ferdinandy P, Danial H, Ambrus I, Rothery RA, Schulz R: Peroxynitrite is a major contributor to cytokine-induced myocardial contractile failure. Circ Res 87:241-247, 2000.
19. Kuebler WM, Abels C, Schuerer L, Goetz AE: Measurement of neutrophil content in brain and lung tissue by a modified myeloperoxidase assay. Int J Microcirc 16:89-97, 1996.
20. Lowry OH, Rosebrough MJ, Far AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275, 1951.
21. Boras M, Kaszaki J, Ördögh B, Nagy S: Intramucosal pH changes following complete segmental small intestinal ischemia, as compared with the effects of superior mesenteric artery occlusion. Eur Surg Res 26:76-86, 1994.
22. Berger MM: Can oxidative damage be treated nutritionally? Clin Nutr 24: 172-183, 2005.
23. Chen LW, Egan L, Li ZW, Greten FR, Kagnoff MF, Karin M: The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med 9: 575-581, 2003.
24. Droge W: Redox regulation in anabolic and catabolic processes. Curr Opin Clin Nutr Metab Care 9:190-195, 2006.
25. Menger MD, Rcker M, Vollmar B: Capillary dysfunction in striated muscle ischemia/reperfusion: on the mechanisms of capillary "no-reflow". Shock 8: 2-7, 1997.
26. Gera L, Varga R, Török L, Kaszaki J, Szabö A, Nagy K, Boras M: Beneficial effects of phosphatidylcholine during hindlimb reperfusion. J Surg Res 139: 45-50, 2007.
27. Drobnik W, Liebisch G, Audebert FX, Frohlich D, Gluck T, Vogel P, Rothe G, Schmitz G: Plasma ceramide and lysophosphatidylcholine inversely correlate with mortality in sepsis patients. J Lipid Res 44:754-761, 2003.
28. Yan JJ, Jung JS, Lee JE, Lee J, Huh SO, Kim HS, Jung KC, Cho JY, Nam JS, Suh HW, et al.: Therapeutic effects of lysophosphatidylcholine in experimental sepsis. Nat Med 10:161-167, 2004.
29. Ilcol YO, Yilmaz Z, Ulus IH: Endotoxin alters serum-free choline and phospholipid-bound choline concentrations, and choline administration attenuates endotoxin-induced organ injury in dogs. Shock 24:288-293, 2005.
30. Kuehl FA, Jacob TA, Ganley OH, Ormond RE, Meisinger MAP: The identification of N-(2-hydroxyethyl)-palmitamide as a naturally occurring anti-inflammatory agent. J Am Chem Soc 79:5577-5578, 1957.
31. Cleland LG, Shandling M, Percy JS, Poznansky MJ: Liposomes: a new approach to gold therapy? J Rheumatol Suppl 5:154-163, 1979.
32. Blusztajn JK, Wurtman RJ: Choline and cholinergic neurons. Science 221: 614-620, 1983.
33. Lee HC, Fellenz-Maloney MP, Liscovitch M, Blusztajn JK: Phospholipase D-catalyzed hydrolysis of phosphatidylcholine provides the choline precursor for acetylcholine synthesis in a human neuronal cell line. Proc Natl Acad Sci U S A 90:10086-10090, 1993.
34. Ulus IH, Wurtman RJ, Mauron C, Blusztajn JK: Choline increases acetylcholine release and protects against the stimulation-induced decrease in phosphatide levels within membranes of rat corpus striatum. Brain Res 484:217-227, 1989.
35. Tracey KJ: Physiology and immunology of the cholinergic antiinflammatory pathway. J Clin Invest 117:289-296, 2007.
36. Thauer RK: Biochemistry of methanogenesis: a tribute to Marjory Stephenson. Microbiology 144:2377-2406, 1998.
37. Boras M, Wolfard A, Ghyczy M: In vivo evidence of reductive stress-induced methane production. Shock S12:56, 1999.
38. Keppler F, Hamilton JT, Brass M, Rockmann T: Methane emissions from terrestrial plants under aerobic conditions. Nature 439:187-191, 2006.