Tyr235 of human cytosolic phosphoenolpyruvate carboxykinase influences catalysis through an anion-quadrupole interaction with phosphoenolpyruvate carboxylate

FEBS Journal

Volumn 275, Issue 23, 2008, Pages 5810-5819

  Dharmarajan, Lakshmi ^a,b   Case, Christopher L ^a,b,d   Dunten, Pete ^c   Mukhopadhyay, Biswarup ^a,b  

^a VIRGINIA BIOINFORMATICS INSTITUTE   (United States)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^c SLAC NATIONAL ACCELERATOR LABORATORY   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Catalysis; Human PEPCK; Kinetics; Site directed mutagenesis; Tyr235

Indexed keywords

ALANINE; HYDROXYL GROUP; MANGANESE; OXALOACETIC ACID; PHENYLALANINE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PHOSPHOENOLPYRUVATE CARBOXYLASE; PHOSPHOPYRUVATE CARBOXYLASE; SERINE; TYROSINE;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CHEMICAL REACTION; CYTOSOL; ENZYME ACTIVITY; HUMAN; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SUBSTITUTION; ANIONS; CARBOXY-LYASES; CATALYSIS; CATALYTIC DOMAIN; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; HUMANS; HYDROGEN BONDING; KINETICS; MANGANESE; MODELS, MOLECULAR; OXALOACETATE; PHOSPHOENOLPYRUVATE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PYRUVATE KINASE; TYROSINE;

EID: 55949103773     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2008.06702.x     Document Type: Article

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