Residues affecting the chloride regulation and substrate selectivity of the angiotensin-converting enzymes (ACE and ACE2) identified by site-directed mutagenesis

FEBS Journal

Volumn 275, Issue 23, 2008, Pages 6033-6042

  Rushworth, Christopher A ^a   Guy, Jodie L ^a   Turner, Anthony J ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Angiotensin; Carboxypeptidase; Chloride; Metalloprotease; Zinc

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 2; ARGININE; CHLORIDE; DIPEPTIDYL CARBOXYPEPTIDASE; LYSINE; TRYPTOPHAN; VASOCONSTRICTOR AGENT; VASODILATOR AGENT;

ARTICLE; BINDING SITE; ENZYME REGULATION; ENZYME SPECIFICITY; MUTANT; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SITE DIRECTED MUTAGENESIS; WILD TYPE;

ALLOSTERIC SITE; AMINO ACID SUBSTITUTION; ANGIOTENSIN I; ANGIOTENSIN II; CAPTOPRIL; CATALYSIS; CATALYTIC DOMAIN; CHLORIDES; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; KINETICS; LEUCINE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PEPTIDYL-DIPEPTIDASE A; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

EID: 55949102926     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2008.06733.x     Document Type: Article

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