Identification of tubulin drug binding sites and prediction of relative differences in binding affinities to tubulin isotypes using digital signal processing

Journal of Molecular Graphics and Modelling

Volumn 27, Issue 4, 2008, Pages 497-505

  Chen, Ke ^a   Huzil, J Torin ^a   Freedman, Holly ^a   Ramachandran, Parameswaran ^b   Antoniou, Andreas ^b   Tuszynski, Jack A ^a   Kurgan, Lukasz ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF VICTORIA   (Canada)

Author keywords

Characteristic frequency; Digital signal processing; Drug affinity; Isotype; Protein hot spot; Resonant recognition model; Short time Fourier transform; Tubulin

Indexed keywords

BINDING ENERGY; BIOCHEMISTRY; CHEMOTHERAPY; DIGITAL ARITHMETIC; DIGITAL SIGNAL PROCESSING; DIGITAL SIGNAL PROCESSORS; DRUG INTERACTIONS; FORECASTING; FOURIER TRANSFORMS; SIGNAL PROCESSING;

CHARACTERISTIC FREQUENCY; DRUG AFFINITY; ISOTYPE; RESONANT RECOGNITION MODEL; SHORT-TIME FOURIER TRANSFORM; TUBULIN;

BINDING SITES;

BETA TUBULIN; BETA TUBULIN I; BETA TUBULIN IIA; BETA TUBULIN IIB; BETA TUBULIN III; BETA TUBULIN IVA; BETA TUBULIN IVB; BETA TUBULIN V; BETA TUBULIN VI; BETA TUBULIN VII; BETA TUBULIN VIII; COLCHICINE; GLUCOSIDE; GUANOSINE DIPHOSPHATE; PACLITAXEL; PELORUSIDE; UNCLASSIFIED DRUG; VINBLASTINE;

ARTICLE; BINDING AFFINITY; DRUG BINDING SITE; DRUG STRUCTURE; FOURIER TRANSFORMATION; PREDICTION; PRIORITY JOURNAL; SIGNAL PROCESSING;

BINDING SITES; COMPUTER SIMULATION; HUMANS; LIGANDS; MODELS, MOLECULAR; PHARMACEUTICAL PREPARATIONS; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; TUBULIN;

EID: 55949099299     PISSN: 10933263     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmgm.2008.09.001     Document Type: Article

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