Genome damage in oropharyngeal cancer patients treated by radiotherapy

Croatian Medical Journal

Volumn 49, Issue 4, 2008, Pages 515-527

  Gamulin, Marija ^a,d   Kopjar, Nevenka ^b   Grgić, Mislav ^a   Ramić, Snježana ^c   Bišof, Vesna ^a   Garaj Vrhovac, Vera ^b  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b INSTITUTE FOR MEDICAL RESEARCH AND OCCUPATIONAL HEALTH   (Croatia)

^c SESTRE MILOSRDNICE UNIVERSITY HOSPITAL   (Croatia)

^d KBC Zagreb   (Croatia)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BLOOD SAMPLING; CANCER RADIOTHERAPY; CANCER RISK; CHROMOSOME ABERRATION; CLINICAL ARTICLE; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; HUMAN; MALE; MICRONUCLEUS TEST; OROPHARYNX CANCER; PERIPHERAL LYMPHOCYTE; RADIATION DOSE; AGED; CROATIA; DRUG EFFECT; FEMALE; GENETICS; GENOME; LEUKOCYTE; MIDDLE AGED; MUTAGEN TESTING; OROPHARYNX TUMOR; PROSPECTIVE STUDY; RADIOTHERAPY; TIME; TREATMENT OUTCOME;

AGED; CHROMOSOME ABERRATIONS; CROATIA; DNA DAMAGE; FEMALE; GENOME, HUMAN; HUMANS; LEUKOCYTES; MALE; MIDDLE AGED; MUTAGENICITY TESTS; OROPHARYNGEAL NEOPLASMS; PROSPECTIVE STUDIES; RADIOTHERAPY; TIME FACTORS; TREATMENT OUTCOME;

EID: 55949084654     PISSN: 03539504     EISSN: 13328166     Source Type: Journal    
DOI: 10.3325/cmj.2008.4.515     Document Type: Article

References (35)

1. Bradley PJ. Management of squamous cell carcinoma of the oropharynx. Head and neck oncology. Curr Opin Otolaryngol Head Neck Surg. 2000;8:80-6.
2. Kabat GC, Chang CJ, Wynder EL. The role of tobacco, alcohol use, and body mass index in oral and pharyngeal cancer. Int J Epidemiol. 1994;23:1137-44.
3. Duffaud F, Orsiere T, Digue L, Villani P, Volot F, Favre R, et al. Micronucleated lymphocyte rates from head-and-neck cancer patients. Mutat Res. 1999;439:259-66.
4. Harreus UA, Kleinsasser NH, Zieger S, Wallner B, Reiter M, Schuller P, et al. Sensitivity to DNA-damage induction and chromosomal alterations in mucosa cells from patients with and without cancer of the oropharynx detected by a combination of Comet assay and fluorescence in situ hybridization. Mutat Res. 2004;563:131-8.
5. Kleinsasser NH, Wallner BC, Wagner C, Kastenbauer ER, Harreus UA. DNA repair capacity in lymphocytes of nasopharyngeal cancer patients. Eur Arch Otorhinolaryngol. 2005;262:561-6.
6. Wang WD, Chen ZT, Li DZ, Cao ZH, Sun SL, Pu P, et al. Correlation between DNA repair capacity in lymphocytes and acute side effects to skin during radiotherapy in nasopharyngeal cancer patients. Clin Cancer Res. 2005;11:5140-5.
7. Di Martino E, Sellhaus B, Hausmann R, Minkenberg R, Lohmann M, Esthofen MW. Survival in second primary malignancies in patients with head and neck cancer. J Laryngol Otol. 2002;116:831-8.
8. de Zwart LL, Meerman JH, Commandeur JN, Vermeulen NP. Biomarkers of free radical damage applications in experimental animals and in humans. Free Radic Biol Med. 1999;26:202-26.
9. Hendry JH. Genomic instability: potential contributions to tumour and normal tissue response, and second tumours, after radiotherapy. Radiother Oncol. 2001;59:117-26.
10. Tucker JD, Preston RJ. Chromosome aberrations, micronuclei, aneuploidy, sister chromatid exchanges, and cancer risk assessment. Mutat Res. 1996;365:147-59.
11. Olive PL, Durand RE, Jackson SM, Le Riche JC, Luo C, Ma R, et al. The comet assay in clinical practice. Acta Oncol. 1999;38:839-44.
12. Kassie F, Parzefall W, Knasmuller S. Single cell gel electrophoresis assay: a new technique for human biomonitoring studies. Mutat Res. 2000;463:13-31.
13. Venkatachalam P, Paul SF, Mohankumar MN, Prabhu BK, Gajendiran N, Kathiresan A, et al. Higher frequency of dicentrics and micronuclei in peripheral blood lymphocytes of cancer patients. Mutat Res. 1999;425:1-8.
14. Baciuchka-Palmaro M, Orsiere T, Duffaud F, Sari-Minodier I, Pompili J, Bellon L, et al. Acentromeric micronuclei are increased in peripheral blood lymphocytes of untreated cancer patients. Mutat Res. 2002;520:189-98.
15. Palyvoda O, Polanska J, Wygoda A, Rzeszowska-Wolny J. DNA damage and repair in lymphocytes of normal individuals and cancer patients: studies by the comet assay and micronucleus tests. Acta Biochim Pol. 2003;50:181-90.
16. National Comprehensive Cancer Network NCCN. Clinical Practice Guidelines in Oncology. Head and Neck Cancers. Available from: http://nccn.org.v.I. Accessed: July 29, 2008.
17. Singh NP, McCoy MT, Tice RR, Schneider EL. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res. 1988;175:184-91.
18. Albertini RJ, Anderson D, Douglas GR, Hagmar L, Hemminki K, Merlo F, et al. IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans. International Programme on Chemical Safety. Mutat Res. 2000;463:111-72.
19. Fenech M, Morley AA. Measurement of micronuclei in lymphocytes. Mutat Res. 1985;147:29-36.
20. Fenech M, Chang WP, Kirsch-Volders M, Holland N, Bonassi S, Zeiger E. HUMN project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures. Mutat Res. 2003;534:65-75.
21. Betti C, Davini T, Giannessi L, Loprieno N, Barale R. Microgel electrophoresis assay (comet test) and SCE analysis in human lymphocytes from 100 normal subjects. Mutat Res. 1994;307:323-33.
22. Garaj-Vrhovac V, Durinec M, Kopjar N, Orescanin V. A survey on the cytogenetic status of the Croatian general population by use of the cytokinesis-block micronucleus assay. Mutat Res. 2008;649:91-100.
23. Kopjar N, Zeljezic D, Garaj-Vrhovac V. Evaluation of DNA damage in white blood cells of healthy human volunteers using the alkaline comet assay and the chromosome aberration test. Acta Biochim Pol. 2006;53:321-36.
24. Cecener G, Egeli U, Tasdelan I, Tunca B, Duman H, Kizil A. Common fragile site expression and genetic predisposition to breast cancer. Teratog Carcinog Mutagen. 1998;18:279-91.
25. Mariano Ruiz de Almodovar J, Guirado D, Isabel Nunez M, Lopez E, Guerrero R, Teresa Valenzuela M, et al. Individualization of radiotherapy in breast cancer patients: possible usefulness of a DNA damage assay to measure normal cell radiosensitivity. Radiother Oncol. 2002;62:327-33.
26. Mendoza-Nunez VM, Sanchez-Rodriguez MA, Retana-Ugalde R, Vargas-Guadarrama LA, Altamirano-Lozano MA. Total antioxidant levels, gender, and age as risk factors for DNA damage in lymphocytes of the elderly. Mech Ageing Dev. 2001;122:835-47.
27. Karaoguz MY, Cosar B, Arikan Z, Basaran F, Menevse A, Menevse S. Increased frequency of sister chromatid exchanges in peripheral lymphocytes of alcoholics and cigarette smokers. Cell Biol Int. 2005;29:165-8.
28. Blasiak J, Trzeciak A, Malecka-Panas E, Drzewoski J, Wojewodzka M. In vitro genotoxicity of ethanol and acetaldehyde in human lymphocytes and the gastrointestinal tract mucosa cells. Toxicol In Vitro. 2000;14:287-95.
29. Maffei F, Fimognari C, Castelli E, Stefanini GF, Forti GC, Hrelia P. Increased cytogenetic damage detected by FISH analysis on micronuclei in peripheral lymphocytes from alcoholics. Mutagenesis. 2000;15:517-23.
30. Mariano Ruiz de Almodovar J, Guirado D, Isabel Nunez I, Lopez E, Guerrero R, Teresa Valenzuela MT, et al. Individualization of radiotherapy in breast cancer patients: possible usefulness of a DNA damage assay to measure normal cell radiosensitivity. Radiother Oncol. 2002;62:327-33.
31. Wolff S. The adaptive response in radiobiology: evolving insights and implications. Environ Health Perspect. 1998;106 Suppl 1:277-83.
32. Bosi A, Olivieri G. Variability of the adaptive response to ionizing radiations in humans. Mutat Res. 1989;211:13-7.
33. El-Zein RA, Schabath MB, Etzel CJ, Lopez MS, Franklin JD, Spitz MR. Cytokinesis-blocked micronucleus assay as a novel biomarker for lung cancer risk. Cancer Res. 2006;66:6449-56.
34. Mohrenweiser HW, Jones IM. Variation in DNA repair is a factor in cancer susceptibility: a paradigm for the promises and perils of individual and population risk estimation? Mutat Res. 1998;400:15-24.
35. Tates AD, van Dam FJ, Natarajan AT, Zwinderman AH, Osanto S. Frequencies of HPRT mutants and micronuclei in lymphocytes of cancer patients under chemotherapy: a prospective study. Mutat Res. 1994;307:293-306.