Extracellular amino acids as markers of myocardial ischemia during cardioplegic heart arrest

Cardiology

Volumn 91, Issue 1, 1999, Pages 31-40

  Kennergren, Charles ^c   Mantovani, Vittorio ^a   Lönnroth, Peter ^c   Nyström, Britta ^c   Berglin, Eva ^c   Hamberger, Anders ^b  

^a UNIVERSITY OF INSUBRIA   (Italy)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c NONE

Author keywords

Amino acids; Glutamate; Glutamine; Ischemia; Microdialysis; Myocardium; Taurine

Indexed keywords

ALANINE; AMINO ACID; GLUTAMIC ACID; GLUTAMINE; GLYCINE; LEUCINE; PHOSPHOETHANOLAMINE; SERINE; TAURINE;

ADULT; AGED; AORTA CLAMPING; ARTICLE; CARDIOPLEGIA; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HEART ARREST; HEART FUNCTION; HEART MUSCLE ISCHEMIA; HUMAN; MALE; MICRODIALYSIS; PATIENT MONITORING; PRIORITY JOURNAL; SEX DIFFERENCE;

ADULT; AGED; AMINO ACIDS; BIOLOGICAL MARKERS; EXTRACELLULAR SPACE; FEMALE; HEART ARREST, INDUCED; HUMANS; INTRAOPERATIVE COMPLICATIONS; MALE; MICRODIALYSIS; MIDDLE AGED; MYOCARDIAL ISCHEMIA; PREDICTIVE VALUE OF TESTS; REFERENCE VALUES;

EID: 0033067224     PISSN: 00086312     EISSN: None     Source Type: Journal    
DOI: 10.1159/000006874     Document Type: Article

References (38)

1. Scheld HH, Mulch J, Schaper J, Hehrlein FW: Myocardial protection over the last 20 years. Med Welt 1982;33:746-749.
2. Inselmann G, Kohler K, Lange V, Silber R, Nellessen U: Lipid peroxidation and cardiac troponin T release during routine cardiac surgery. Cardiology 1998;89:124-129.
3. Katus HA, Schoeppenthau M, Tanzeem A, Bauer HG, Saggau W, Diederich KW, Hagl S, Kübler W: Non-invasive assessment of perioperative myocardial cell damage by circulating cardiac troponin T. Br Heart J 1991;65:259-264.
4. Carrier M, Solymoss BC, Cartier R, Leclerc Y, Pelletier LC: Cardiac troponin T and creatine kinase MB isoenzyme as biochemical markers of ischemia after heart preservation and transplantation. J Heart Lung Transplant 1994;13: 696-700.
5. Eikvar L, Pillgram LJ, Skjaeggestad O, Arnesen H, Stromme JH: Serum cardio-specific troponin T after open heart surgery in patients with and without perioperative myocardial infarction. Scand J Clin Lab Invest 1994;54:329-335.
6. Hake U, Schmid FX, Iversen S, Dahm M, Mayer E, Hafner G, Oelert H: Troponin T: A reliable marker of perioperative myocardial infarction? Eur J Cardiothorac Surg 1993;7:628-633.
7. Machler H, Gombotz H, Sabin K, Metzler H: Troponin T as a marker of perioperative myocardial cell damage. Adv Pharmacol 1994;31: 63-73.
8. Mair J, Wieser C, Seibt I, Arther DE, Furtwängler W, Waldenberger F, Balough D, Puschendorf B: Troponin T do diagnose myocardial infarction in bypass surgery (letter). Lancet 1991;337:434-435.
9. Metzler H, Gries M, Rehak P, Lang T, Frühwald S, Toller W: Perioperative myocardial cell injury: The role of troponins. Br J Anaesthesiol 1997;78:386-390.
10. Triggiani M, Simeone F, Gallorini C, Paolini G, Donatelli F, Paolillo G, Dolci A, Grossi A: Measurement of cardiac troponin T and myosin to detect perioperative myocardial damage during coronary surgery. Cardiovasc Surg 1994;2:441-445.
11. Zimmermann R, Baki S, Dengler TJ, Ring GH, Remppis A, Lange R, Hagl S, Kübler W, Katus HA: Troponin T release after heart transplantation. Br Heart J 1993;69:395-398.
12. Kimose HH, Ravkilde J, Helligso P, Knudsen MA, Thomassen AR, Nielsen TT, Djurhuus JC: Myocardial loss of glutamate after cold chemical cardioplegia and storage in isolated blood-perfused pig hearts. Thorac Cardiovasc Surg 1993;41:93-100.
13. Pisarenko OI, Baranov AV, Aleshin OI, Studneva IM, Pomerantsev EA, Nikolaeva LF, Savchenko AP, Pavlov NA: Features of myocardial metabolism of some amino acids and ammonia in patients with coronary artery disease. Eur Heart J 1989:10:209-217.
14. Song D, O'Regan MH, Phillis JW: Release of the excitotoxic amino acids, glutamate and aspartate, from the isolated ischemic/anoxic rat heart. Neurosci Lett 1996;220:1-4.
15. Wiesner RJ, Deussen A, Borst M, Schrader J, Grieshaber MK: Glutamate degradation in the ischemic dog heart: Contribution to anaerobic energy production. J Mol Cell Cardiol 1989;21: 49-59.
16. Tischler ME, Goldberg AL: Production of alanine and glutamine by atrial muscle from fed and fasted rats. Am J Physiol 1980;238:E487-493.
17. Takala T, Hiltunen JK, Hassinen IE: The mechanism of ammonia production and the effect of mechanical work load on proteolysis and amino acid catabolism in isolated perfused rat heart. Biochem J 1980;192:285-295.
18. Suleiman MS, Fernando HC, Dihmis WC, Hutter JA, Chapman RA: A loss of taurine and other amino acids from ventricles of patients undergoing bypass surgery. Br Heart J 1993;69: 241-245.
19. Lombardini JB, Bricker DL: Effects of cardiovascular surgery on blood concentrations of taurine and amino acids. Proc Soc Exp Biol Med 1981;167:498-505.
20. Cooper MW, Lombardini JB: Elevated blood taurine levels after myocardial infarction of cardiovascular surgery: Is there any significance? Adv Exp Med Biol 1981;139:191-205.
21. Bomfim V, Kaijser L, Bendz R, Sylven C, Morillo F, Olin C: Myocardial protection during aortic valve replacement: Cardiac metabolism and enzyme release following continuous blood cardioplegia. Scand J Thorac Cardiovasc Surg 1981;15:141-147.
22. Kennergren C, Nyström B, Nyström U, Berglin E, Larsson G, Mantovani V, Lönnroth P, Hamberger A: In situ detection of myocardial infarction in pig by measurements of aspartate aminotransferase (ASAT) activity in the interstitial fluid. Scand Cardiovasc J 1997;31:343-349.
23. Langemann H, Habicht J, Mendelowitsch A, Kanner A, Alessandri B, Landolt H, Gratzl O: Microdialytic monitoring during a cardiovascular operation. Acta Neurochir Suppl (Wien) 1996;67:70-74.
24. Obata T, Hosokawa H, Yamanaka Y: In vivo monitoring of norepinephrine and ·OH generation on myocardial ischemic injury by dialysis technique. Am J Physiol 1994:H903-908.
25. Mertes PM, Carteaux JP, Jaboin Y, Pinelli G, El AK, Dopff C, Atkinson J, Villemot JP, Burlet C, Boulange M: Estimation of myocardial interstitial norepinephrine release after brain death using cardiac microdialysis. Transplantation 1994;57:371-377.
26. Van WD, Schmit TJ, Lasley RD, Gingell RL, Mentzer RJ: Cardiac microdialysis in isolated rat hearts: Interstitial purine metabolites during ischemia. Am J Physiol 1992:H1934-1938.
27. Buratta S, Hamberger A, Ryberg H, Nyström B, Sandberg M, Mozzi R: Effect of serine and ethanolamine administration on phospholipid-related compounds and neurotransmitter amino acids in the rabbit hippocampus. J Neurochem 1998;71:2145-2150.
28. Jansson PA, Fowelin JP, von Schenck HP, Smith UP, Lönnroth PN: Measurement by microdialysis of the insulin concentration in subcutaneous interstitial fluid: Importance of the endothelial barrier for insulin. Diabetes 1993; 42:1469-1473.
29. Lindroth P, Mopper K: High-performance liquid chromatographic determination of subpicomole amounts of amino acids by precolumn fluorescence derivatization with O-phthaldialdehyde. Anal Chem 1979:51:1667-1674.
30. Katus HA, Looser S, Hallermayer K, Remppis A, Scheffold T, Borgya A, Essig U, Geuss U: Development and in vitro characterization of a new immunoassay of cardiac troponin T. Clin Chem 1992;38:386-393.
31. Chemistry IFoC: Committee on Standards Enzyme Panel. Clin Chem 1978;21:720-721.
32. Hamberger A, Nyström B, Silvenius H, Wikkelso C: The contribution from the choroid plexus and the periventricular CNS to amino acids and proteins in the human CSF. Neurochem Res 1990;15:307-312.
33. Peck EJ Jr, Awapara J: Formation of taurine and isethionic acid in rat brain. Biochim Biophys Acta 1967;141:499-506.
34. Pisarenko OI, Oleynikov OD, Shulzhenko VS, Studneva IM, Ryff IM, Kapelko VI: Association of myocardial glutamate and aspartate pool and functional recovery of postischemic heart. Biochem Med Metab Biol 1989:42:105-117.
35. Engleman RM, Rousou JA, Flack JE, Iyengar J, Kimura Y, Das DK: Reduction of infarct size by systemic amino acid supplementation during reperfusion. J Thorac Cardiovasc Surg 1991;101:855-859.
36. Thomassen AR: Myocardial uptake and effects of glutamate during non-ischaemic and ischaemic conditions: A clinical study with special reference to possible interrelationships between glutamate and myocardial utilization of carbohydrate substrates. Dan Med Bull 1992; 39:471-488.
37. Hagberg H, Lehmann A, Sandberg M, Nyström B, Jacobson I, Hamberger A: Ischemia-induced shift of inhibitory and excitatory amino acids from intra- to extracellular compartments. J Cereb Blood Flow Metab 1985;5:413-419.
38. + ATPase in rat brain microsomes. Neurochem Res 1983;8:1185-1195.