A proteomic screen reveals SCFGrr1 targets that regulate the glycolytic-gluconeogenic switch

Nature Cell Biology

Volumn 9, Issue 10, 2007, Pages 1184-1191

  Benanti, Jennifer A ^a   Cheung, Stephanie K ^a   Brady, Mariska C ^a   Toczyski, David P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

F BOX PROTEIN; FRUCTOSE 2,6 BISPHOSPHATASE; GLUCOSE; PROTEIN GRR1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PFK27; TRANSCRIPTION FACTOR SNF; TRANSCRIPTION FACTOR SNF1; TRANSCRIPTION FACTOR TYE7; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE REGULATION; CELL GROWTH; CELL METABOLISM; CONTROLLED STUDY; GLUCONEOGENESIS; GLYCOLYSIS; GROWTH INHIBITION; HIGH THROUGHPUT SCREENING; MICROSCOPY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEOMICS; QUANTITATIVE ANALYSIS;

BLOTTING, WESTERN; DNA-BINDING PROTEINS; GLUCONEOGENESIS; GLYCOLYSIS; PROTEIN BINDING; PROTEOMICS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SACCHAROMYCES CEREVISIAE PROTEINS; SKP CULLIN F-BOX PROTEIN LIGASES; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; UBIQUITIN-PROTEIN LIGASES;

EID: 34848817448     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1639     Document Type: Article

References (27)

1. Willems, A. R., Schwab, M. & Tyers, M. A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kin. Biochim. Biophys. Acta 1695, 133-170 (2004).
2. Petroski, M. D. & Deshaies, R. J. Function and regulation of cullin-RING ubiquitin ligases. Nature Rev. Mol. Cell Biol. 6, 9-20 (2005).
3. Cardozo, T. & Pagano, M. The SCF ubiquitin ligase: Insights into a molecular machine. Nature Rev. Mol. Cell Biol 5, 739-751 (2004).
4. Flick, J. S. & Johnston, M. GRR1 of Saccharomyces cerevisiae is required for glucose repression and encodes a protein with leucine-rich repeats. Mol. Cell. Biol. 11, 5101-5112 (1991).
5. Flick, K. M. et al. Grr1-dependent inactivation of Mth1 mediates glucose-induced dissociation of Rgt1 from HXT gene promoters. Mol. Biol. Cell 14, 3230-3241 (2003).
6. Grr1 targets in the glucose and amino acid signaling pathways. Mol. Cell. Biol. 24 8994-9005 (2004).
7. Andreasson, C. & Ljungdahl, P. O. The N-terminal regulatory domain of Stp1p is modular and, fused to an artificial transcription factor, confers full Ssy1p-Ptr3p-Ssy5p sensor control. Mol. Cell. Biol. 24, 7503-7513 (2004).
8. Barral, Y., Jentsch, S. & Mann, C. G1 cyclin turnover and nutrient uptake are controlled by a common pathway in yeast. Genes Dev. 9, 399-409 (1995).
9. Jaquenoud, M., Gulli, M. P., Peter, K. & Peter, M. The Cdc42p effector Gic2p is targeted for ubiquitin-dependent degradation by the SCFGrr1 complex. EMBO J. 17, 5360-5373 (1998).
10. Blondel, M. et al. Degradation of Hof1 by SCF(Grr1) is important for actomyosin contraction during cytokinesis in yeast. EMBO J. 24, 1440-1452 (2005).
11. Grr1 p-dependent destruction of Ime2p kinase. Mol. Cell. Biol. 25, 440-450 (2005).
12. Huh, W. K. et al. Global analysis of protein localization in budding yeast. Nature 425, 686-691 (2003).
13. Eckert-Boulet, N., Regenberg, B. & Nielsen, J. Grr1p is required for transcriptional induction of amino acid permease genes and proper transcriptional regulation of genes in carbon metabolism of Saccharomyces cerevisiae. Curr. Genet. 47, 139-149 (2005).
14. Gardner, R. G., Nelson, Z. W. & Gottschling, D. E. Degradation-mediated protein quality control in the nucleus. Cell 120, 803-815 (2005).
15. Kishi, T. & Yamao, F. An essential function of Grr1 for the degradation of Cln2 is to act as a binding core that links Cln2 to Skp1. J. Cell Sci. 111, 3655-3661 (1998).
16. Hsiung, Y. G. et al. F-box protein Grr1 interacts with phosphorylated targets via the cationic surface of its feucine-rich repeat. Mol. Cell. Biol. 21, 2506-2520 (2001).
17. Andreasson, C. & Ljungdahl, P. O. Receptor-mediated endoproteolytic activation of two transcription factors in yeast. Genes Dev. 16 3158-3172 (2002).
18. Okar, D. A. & Lange, A. J. Fructose-2,6-bisphosphate and control of carbohydrate metabolism in eukaryotes. Biofactors 10, 1-14 (1999).
19. Nishi, K. et al. The GCR1 requirement for yeast glycolytic gene expression is suppressed by dominant mutations in the SGC1 gene, which encodes a novel basic-helix-loop-helix protein. Mol. Cell. Biol. 15, 2646-2653 (1995).
20. Moriya, H. & Johnston, M. Glucose sensing and signaling in Saccharomyces cerevisiae through the Rgt2 glucose sensor and casein kinase I. Proc. Natl Acad. Sci. USA 101, 1572-1577 (2004).
21. Ptacek, J. et al. Global analysis of protein phosphorylation in yeast. Nature 438, 679-684 (2005).
22. Dale, S., Wilson, W. A., Edelman, A. M. & Hardie, D. G. Similar substrate recognition motifs for mammalian AMP-activated protein kinase, higher plant HMG-CoA reductase kinase-A, yeast SNF1, and mammalian calmodulin-dependent protein kinase I. FEBS Lett. 361, 191-195 (1995).
23. Goncalves, P. M., Griffioen, G., Bebelman, J. P. & Planta, R. J. Signalling pathways leading to transcriptional regulation of genes involved in the activation of glycolysis in yeast. Mol. Microbiol. 25, 483-493 (1997).
24. Tang, X. et al. Genome-wide surveys for phosphorylation-dependent substrates of SCF ubiquitin ligases. Methods Enzymol. 399, 433-458 (2005).
25. Ghaemmaghami, S. et al. Global analysis of protein expression in yeast. Nature 425, 737-741 (2003).
26. Schmitt, M. E., Brown, T. A. & Trumpower, B. L. A rapid and simple method for preparation of RNA from Saccharomyces carevisiae. Nucleic Acids Res. 18, 3091-3092 (1990).
27. Espinoza, F. H. et al. Cak1 is required for Kin28 phosphorylation and activation in vivo. Mol. Cell. Biol. 18, 6365-6373 (1998).