The malignant phenotype of breast cancer cells is reduced by COX-2 silencing

Neoplasia

Volumn 10, Issue 11, 2008, Pages 1163-1169

  Stasinopoulos, Ioannis ^a   Mori, Noriko ^a   Bhujwalla, Zaver M ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; HYALURONAN SYNTHASE 2; LACTIC ACID; SYNTHETASE; TISSUE CULTURE MEDIUM; UNCLASSIFIED DRUG;

ACIDIFICATION; ARTICLE; BREAST CANCER; CANCER CELL; CELL SECRETION; COCULTURE; CONTROLLED STUDY; CULTURE MEDIUM; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; UMBILICAL VEIN;

EID: 55849113337     PISSN: 15228002     EISSN: 14765586     Source Type: Journal    
DOI: 10.1593/neo.08568     Document Type: Article

References (33)

1. De Marzo AM, Platz EA, Sutcliffe S, Xu J, Gronberg H, Drake CG, Nakai Y, Isaacs WB, and Nelson WG (2007). Inflammation in prostate carcinogenesis. Nat Rev Cancer 7, 256-269.
2. Wang D and DuBois RN (2007). Inflammatory mediators and nuclear receptor signaling in colorectal cancer. Cell Cycle 6, 682-685.
3. Diaz-Cruz ES and Brueggemeier RW (2006). Interrelationships between cyclooxygenases and aromatase: unraveling the relevance of cyclooxygenase inhibitors in breast cancer. Anticancer Agents Med Chem 6, 221-232.
4. 2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression. Proc Natl Acad Sci USA 101, 591-596.
5. Stasinopoulos I, O'Brien DR, Wildes F, Glunde K, and Bhujwalla ZM (2007). Silencing of cyclooxygenase-2 inhibits metastasis and delays tumor onset of poorly differentiated metastatic breast cancer cells. Mol Cancer Res 5, 435-442.
6. Gupta GP, Nguyen DX, Chiang AC, Bos PD, Kim JY, Nadal C, Gomis RR, Manova-Todorova K, and Massague J (2007). Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. Nature 446, 765-770.
7. Nguyen DX and Massague J (2007). Genetic determinants of cancer metastasis. Nat Rev Genet 8, 341-352.
8. Papandreou I, Cairns RA, Fontana L, Lim AL, and Denko NC (2006). HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab 3, 187-197.
9. Kim JW and Dang CV (2006). Cancer's molecular sweet tooth and the Warburg effect. Cancer Res 66, 8927-8930.
10. Fischer K, Hoffmann P, Voelkl S, Meidenbauer N, Ammer J, Edinger M, Gottfried E, Schwarz S, Rothe G, Hoves S, et al. (2007). Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood 109, 3812-3819.
11. Gatenby RA, Gawlinski ET, Gmitro AF, Kaylor B, and Gillies RJ (2006). Acid-mediated tumor invasion: a multidisciplinary study. Cancer Res 66, 5216-5223.
12. Fukumura D and Jain RK (2007). Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization. Microvasc Res 74, 72-84.
13. Day AJ and de la Motte CA (2005). Hyaluronan cross-linking: a protective mechanism in inflammation? Trends Immunol 26, 637-643.
14. Fischer JW and Schror K (2007). Regulation of hyaluronan synthesis by vasodilatory prostaglandins. Implications for atherosclerosis. Thromb Haemost 98, 287-295.
15. Zoltan-Jones A, Huang L, Ghatak S, and Toole BP (2003). Elevated hyaluronan production induces mesenchymal and transformed properties in epithelial cells. J Biol Chem 278, 45801-45810.
16. Udabage L, Brownlee GR, Waltham M, Blick T, Walker EC, Heldin P, Nilsson SK, Thompson EW, and Brown TJ (2005). Antisense-mediated suppression of hyaluronan synthase 2 inhibits the tumorigenesis and progression of breast cancer. Cancer Res 65, 6139-6150.
17. Sawyer SJ, Norvell SM, Ponik SM, and Pavalko FM (2001). Regulation of PGE(2) and PGI(2) release from human umbilical vein endothelial cells by actin cytoskeleton. Am J Physiol Cell Physiol 281, C1038-C1045.
18. 2 stimulates angiogenesis by activating the nitric oxide/cGMP pathway in human umbilical vein endothelial cells. Exp Mol Med 37, 588-600.
19. Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U, and Speed TP (2003). Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4, 249-264.
20. Glunde K, Raman V, Mori N, and Bhujwalla ZM (2005). RNA interference-mediated choline kinase suppression in breast cancer cells induces differentiation and reduces proliferation. Cancer Res 65, 11034-11043.
21. Bergersen LH (2007). Is lactate food for neurons? Comparison of monocarboxylate transporter subtypes in brain and muscle. Neuroscience 145, 11-19.
22. Chan BS, Endo S, Kanai N, and Schuster VL (2002). Identification of lactate as a driving force for prostanoid transport by prostaglandin transporter PGT. Am J Physiol Renal Physiol 282, F1097-F1102.
23. + exchanger inhibitors. J Pharmacol Exp Ther 321, 345-352.
24. Manning BD and Cantley LC (2007). AKT/PKB signaling: navigating downstream. Cell 129, 1261-1274.
25. Holderfield MT and Hughes CC (2008). Crosstalk between vascular endothelial growth factor, notch, and transforming growth factor-beta in vascular morphogenesis. Circ Res 102, 637-652.
26. Tsujii M, Kawano S, Tsuji S, Sawaoka H, Hori M, and DuBois RN (1998). Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 93, 705-716.
27. Orimo A and Weinberg RA (2006). Stromal fibroblasts in cancer: a novel tumor-promoting cell type. Cell Cycle 5, 1597-1601.
28. Luker KE and Luker GD (2006). Functions of CXCL12 and CXCR4 in breast cancer. Cancer Lett 238, 30-41.
29. Fujiwara M, Ghazizadeh M, and Kawanami O (2006). Potential role of the Slit/ Robo signal pathway in angiogenesis. Vasc Med 11, 115-121.
30. Prasad A, Fernandis AZ, Rao Y, and Ganju RK (2004). Slit protein-mediated inhibition of CXCR4-induced chemotactic and chemoinvasive signaling pathways in breast cancer cells. J Biol Chem 279, 9115-9124.
31. Masckauchan TN, Shawber CJ, Funahashi Y, Li CM, and Kitajewski J (2005). Wnt/beta-catenin signaling induces proliferation, survival and interleukin-8 in human endothelial cells. Angiogenesis 8, 43-51.
32. Uutela M, Wirzenius M, Paavonen K, Rajantie I, He Y, Karpanen T, Lohela M, Wiig H, Salven P, Pajusola K, et al. (2004). PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Blood 104, 3198-3204.
33. Yamauchi M, Imajoh-Ohmi S, and Shibuya M (2007). Novel antiangiogenic pathway of thrombospondin-1 mediated by suppression of the cell cycle. Cancer Sci 98, 1491-1497.