Alterations in the expression pattern of TCR ζ chain in T cells from patients with hematological diseases

Hematology

Volumn 13, Issue 5, 2008, Pages 267-275

  Li, Yangqiu ^a  

^a JINAN UNIVERSITY   (China)

Author keywords

CR chain; Hematological disease; TCR CD3 complex

Indexed keywords

CD3 ANTIBODY; CD30 ANTIBODY; DEXAMETHASONE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD28; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ZETA CHAIN; UNCLASSIFIED DRUG;

APLASTIC ANEMIA; B CELL LEUKEMIA; CELLULAR IMMUNITY; DISEASE ASSOCIATION; GENE EXPRESSION; GENE MUTATION; GENETIC POLYMORPHISM; GENETIC REGULATION; GENETIC VARIABILITY; HEMATOLOGIC DISEASE; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IMMUNE DEFICIENCY; IMMUNOMODULATION; IMMUNOTHERAPY; LYMPHATIC LEUKEMIA; LYMPHOMA; MYELOID LEUKEMIA; NONHUMAN; POLYCYTHEMIA VERA; PRIORITY JOURNAL; PROGNOSIS; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; REVIEW; RISK FACTOR; RNA SPLICING; SIGNAL TRANSDUCTION; T CELL LEUKEMIA; T LYMPHOCYTE; T LYMPHOCYTE RECEPTOR GENE;

GENE EXPRESSION REGULATION; HEMATOLOGIC DISEASES; HUMANS; MUTATION; PROTEIN ISOFORMS; RECEPTORS, ANTIGEN, T-CELL;

EID: 55849101109     PISSN: 10245332     EISSN: 16078454     Source Type: Journal    
DOI: 10.1179/102453308X343482     Document Type: Review

References (63)

1. Weissman AM, Samelson LE, Klausner RD. A new subunit of the human T-cell antigen receptor complex. Nature 1986; 324: 480-482.
2. Samelson LE, Harford JB, Klausner RD. Identification of the components of the murine T cell antigen receptor complex. Cell 1985; 43: 223-231.
3. Ciszak L, Pawlak E, Kosmaczewska A, Potoczek S, Frydecka I. Alterations in the expression of signal-transducing CD3 zeta chain in T cells from patients with chronic inflammatory/autoimmune diseases. Arch Immunol Ther Exp (Warsz) 2007; 55: 373-586.
4. Li Y, Leukemia associated clonal expansion TCR Vβ subfamily T cells. Hematology 2003; 8: 375-384.
5. Li Y, Chen S, Yang L et al. Clonal expanded TCR Vβ T cells in patients with APL. Hematology 2005; 10: 135-139.
6. Chen X, Woiciechowsky A, Raffegerst S, Schendel D, Kolb HJ, Roskrow M. Impaired expression of the CD3-zeta chain in peripheral blood T cells of patients with chronic myeloid leukaemia results in an increased susceptibility to apoptosis. Br J Haematol 2000; 111: 817-825.
7. Solomon EE, Wong S, Visconte V, Gibellini F, Young NS. Decreased TCR zeta-chain expression in T cells from patients with acquired aplastic anaemia. Br J Haematol 2007; 138: 72-76.
8. Torelli GF, Paolini R, Tatarelli C et al. Defective expression of the T-cell receptor-CD3 zeta chain in T-cell acute lymphoblastic leukaemia. Br J Haematol 2003; 120: 201-208.
9. Weissman AM, Hou D, Orloff DG et al. Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: distinction from the molecular CD3 complex. Proc Natl Acad Sci USA 1988; 85: 9709-9713.
10. Baniyash M, Hsu VW, Seldin MF, Klausner RD. The isolation and characterization of the murine T cell antigen receptor zeta chain gene. J Biol Chem 1989; 264: 13252-13257.
11. Jensen JP, Hou D, Ramsburg M, Taylor A, Dean M, Weissman AM. Organization of the human T cell receptor zeta/eta gene and its genetic linkage to the Fc gamma RII-Fc gamma RIII gene cluster. J Immunol 1992; 148: 2563-2571.
12. Pitcher LA, Mathis MA, Subramanian S et al. Selective expression of the 21-kilodalton tyrosine-phosphorylated form of TCR zeta promotes the emergence of T cells with autoreactive potential. J Immunol 2005; 174: 6071-6079.
13. Pitcher LA, Young JA, Mathis MA, Wrage PC, Bartók B, van Oers NS. The formation and functions of the 21- and 23-kDa tyrosine-phosphorylated TCR zeta subunits. Immunol Rev 2003; 191: 47-61.
14. Samelson LE, Davidson WF, Morse HCIII, Klausner RD. Abnormal tyrosine phosphorylation on T-cell receptor in lymphoproliferative disorders. Nature 1986; 324: 674-676.
15. Pitcher LA, van Oers NS. T-cell receptor signal transmission: who gives an ITAM? Trends Immunol 2003; 24: 554-560.
16. Chitu V, Fajka-Boja R, Tóth GKMorse HCIII, Klausner RD. Abnormal tyrosine phosphorylation on T-cell receptor in lymphoproliferative disorders. Comparative study on the effect of phosphorylated TCR zeta chain ITAM sequences on early activation events in Jurkat T cells. Peptides 2001; 22: 1963-1971.
17. Shores EW, Love PE. TCR zeta chain in T cell development and selection. Curr Opin Immunol 1997; 9: 380-389.
18. Wiest DL, Kearse KP, Shores EW, Singer A. Developmentally regulated expression of CD3 components independent of clonotypic T cell antigen receptor complexes on immature thymocytes. J Exp Med 1994; 180: 1375-1382.
19. Crompton T, Moore M, MacDonald HR, Malissen B. Double-negative thymocyte subsets in CD3 zeta chain-deficient mice: absence of HSA+CD44-CD25- cells. Eur J Immunol 1994; 24: 1903-1907.
20. van Oers NS, von Boehmer H, Weiss A. The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-zeta subunit. J Exp Med 1995; 182: 1585-1590.
21. Shores EW, Huang K, Tran T, Lee E, Grinberg A, Love PE. Role of TCR zeta chain in T cell development and selection. Science 1994; 266: 1047-1050.
22. Simpson S, Holländer G, She J, Levelt C, Huang M, Terhorst C. Selection of peripheral and intestinal T lymphocytes lacking CD3 zeta. Int Immunol 1995; 7: 287-293.
23. Shores EW, Tran T, Grinberg A, Sommers CL, Shen H, Love PE. Role of the multiple T cell receptor (TCR)-zeta chain signaling motifs in selection of the T cell repertoire. J Exp Med 1997; 185: 893-900.
24. Love PE, Lee J, Shores EW. Critical relationship between TCR signaling potential and TCR affinity during thymocyte selection. J Immunol 2000; 165: 3080-3087.
25. Minguet S, Swamy M, Dopfer EP, Dengler E, Alarcón B, Schamel WW. The extracellular part of zeta is buried in the T cell antigen receptor complex. Immunol Lett 2008; 116: 203-210.
26. Minguet S, Swamy M, Schamel WW. The short length of the extracellular domain of zeta is crucial for T cell antigen receptor function. Immunol Lett 2008; 116: 195-202.
27. Weissman AM, Baniyash M, Hou D, Samelson LE, Burgess WH, Klausner RD. Molecular cloning of the zeta chain of the T cell antigen receptor. Science 1988; 239: 1018-1021.
28. Stacey M, Barlow A, Hulten M. Human T-cell receptor zeta chain gene Map position 1q23.1. Chromosome Res 1997; 5: 279.
29. Nambiar MP, Enyedy EJ, Warke VG et al. T cell signaling abnormalities in systemic lupus erythematosus are associated with increased mutations/polymorphisms and splice variants of T cell receptor zeta chain messenger RNA. Arthritis Rheum 2001; 44: 1336-1350.
30. Frank SJ, Niklinska BB, Orloff DG, Merćep M, Ashwell JD, Klausner RD. Structural mutations of the T cell receptor zeta chain and its role in T cell activation. Science 1990; 249: 174-177.
31. Wu J, Edberg JC, Gibson AW, Tsao B, Kimberly RP. Single-nucleotide polymorphisms of T cell receptor zeta chain in patients with systemic lupus erythematosus. Arthritis Rheum 1999; 42: 2601-2605.
32. Moingeon P, Stebbins CC, D'Adamio L, Lucich J, Reinherz EL. Human natural killer cells and mature T lymphocytes express identical CD3 zeta subunits as defined by cDNA cloning and sequence analysis. Eur J Immunol 1990; 20: 1741-1745.
33. Takeuchi T, Tsuzaka K, Pang M, Amano K, Koide J, Abe T. TCR zeta chain lacking exon 7 in two patients with systemic lupus erythematosus. Int Immunol 1998; 10: 911-921.
34. Tsuzaka K, Fukuhara I, Setoyama Y et al. TCR zeta mRNA with an alternatively spliced 3′-untranslated region detected in systemic lupus erythematosus patients leads to the down-regulation of TCR zeta and TCR/CD3 complex. J Immunol 2003; 171: 2496-2503.
35. Nambiar MP, Enyedy EJ, Warke VG et al. Polymorphisms/mutations of TCR-zeta-chain promoter and 3′ untranslated region and selective expression of TCR zeta-chain with an alternatively spliced 3′ untranslated region in patients with systemic lupus erythematosus. J Autoimmun 2001; 16: 133-142.
36. Atkinson TP, Hall CG, Goldsmith J, Kirkham PM. Splice variant in TCRzeta links T cell receptor signaling to a G-protein-related signaling pathway. Biochem Biophys Res Commun 2003; 310: 761-766.
37. Tsuzaka K, Setoyama Y, Yoshimoto K et al. A splice variant of the TCR zeta mRNA lacking exon 7 leads to the down-regulation of TCR zeta, the TCR/CD3 complex, and IL-2 production in systemic lupus erythematosus T cells. J Immunol 2005; 174: 3518-3525.
38. Tsuzaka K, Nozaki K, Kumazawa C et al. DNA microarray gene expression profile of T cells with the splice variants of TCRzeta mRNA observed in sy stemic lupus erythematosus. J Immunol 2006; 176: 949-956.
39. Isuzaka K, Itami Y, kumazawa C et al. Conservative sequences in 3′UTR of TCRzeta mRNA regulate TCRzeta in SLE T cells. Biochem Biophys Res Commun 2008; 367: 311-317.
40. Mizoguchi H, O'Shea JJ, Longo DL, Loeffler CM, McVicar DW, Ochoa AC. Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice. Science 1992; 258: 1795-1798.
41. Lai P, Rabinowich H, Crowley-Nowick PA, Bell MC, Mantovani G, Whiteside TL. Alterations in expression and function of signal-transducing proteins in tumor-associated T and natural killer cells in patients with ovarian carcinoma. Clin Cancer Res 1996; 2: 161-173.
42. Zea AH, Curti BD, Longo DL et al. Alterations in T cell receptor and signal transduction molecules in melanoma patients. Clin Cancer Res 1995; 1: 1327-1335.
43. Finke JH, Rayman P, Hart L et al. Characterization of tumor-infiltrating lymphocyte subsets from human renal cell carcinoma: specific reactivity defined by cytotoxicity, interferon-gamma secretion, and proliferation. J Immunother Emphasis Tumor Immunol 1994; 15: 91-104.
44. Kuss I, Saito T, Johnson JT, Whiteside TL. Clinical significance of decreased zeta chain expression in peripheral blood lymphocytes of patients with head and neck cancer. Clin Cancer Res 1999; 5: 329-334.
45. Yang L, Li Y, Li C, Chen S, Chen S, Lin C. Expression pattern of TCR-zeta chain in patients with aplastic anemia and polycythemia vera. Blood 2007; 110: 7B.
46. Zhang X, Li Y, Chen S et al. The feature of TCR Vβ repertoire, thymic recent output function and TCR-zeta chain expression in patients with immune thrombocytopenic purpura. Blood 2007; 110: 625A.
47. Suzushima H, Hattori T, Asou N et al. Discordant gene and surface expression of the T-cell receptor/CD3 complex in adult T-cell leukemia cells. Cancer Res 1991; 51: 6084-6088.
48. de Waal Malefyt R, Yssel H, Spits H et al. Human T cell leukemia virus type I prevents cell surface expression of the T cell receptor through down-regulation of the CD3-gamma, -delta, -epsilon, and -zeta genes. J Immunol 1990; 145: 2297-2303.
49. Vitale B, Martinis M, Antica M et al. Prolegomenon for chronic lymphocytic leukaemia. Scand J Immunol 2003; 58: 588-600.
50. Kiaii S, Choudhury A, Mozaffari F, Kimby E, Osterborg A, Mellstedt H. Signaling molecules and cytokine production in T cells of patients with B-cell chronic lymphocytic leukemia (B-CLL): comparison of indolent and progressive disease. Med Oncol 2005; 22: 291-302.
51. Buggins AG, Hirst WJ, Pagliuca A, Mufti GJ. Variable expression of CD3-zeta and associated protein tyrosine kinases in lymphocytes from patients with myeloid malignancies. Br J Haematol 1998; 100: 784-792.
52. Chen S, Li Y, Chen S, Yang L, Wu X, Cen D. The feature of TCR zeta gene in CD4+ and CD8+ T cells in patients with CML. Blood 2007; 110: 203B.
53. Slivnick DJ, Ellis TM, Nawrocki JF, Fisher RI. The impact of Hodgkin's disease on the immune system. Semin Oncol 1990; 17: 673-782.
54. Bonzheim I, Geissinger E, Roth S et al. Anaplastic large cell lymphomas lack the expression of T-cell receptor molecules or molecules of proximal T-cell receptor signaling. Blood 2004; 104: 3358-3360.
55. Wang Q, Stanley J, Kudoh S et al. T cells infiltrating non-Hodgkin's B cell lymphomas show altered tyrosine phosphorylation pattern even though T cell receptor/CD3-associated kinases are present. J Immunol 1995; 155: 1382-1392.
56. Renner C, Ohnesorge S, Held G et al. T cells from patients with Hodgkin's disease have a defective T-cell receptor zeta chain expression that is reversible by T-cell stimulation with CD3 and CD28. Blood 1996; 88: 236-241.
57. Dukers DF, Oudejans JJ, Jaspars EH et al. All infiltrating T-lymphocytes in Hodgkin's disease express immunohistochemically detectable T-cell receptor zeta-chains in situ. Histopathology 2000; 36: 544-550.
58. Kono K, Salazar-Onfray F, Petersson M et al. Hydrogen peroxide secreted by tumor-derived macrophages down-modulates signal-transducing zeta molecules and inhibits tumor-specific T cell-and natural killer cell-mediated cytotoxicity. Eur J Immunol 1996; 26: 1308-1313.
59. Hirst W, Buggins A, Mufti G. Central role of leukemia-derived factors in the development of leukemia-associated immune dysfunction. Hematol J 2001; 2: 2-17.
60. Nambiar MP, Enyedy EJ, Fisher CU, Warke VG, Juang YT, Tsokos GC. Dexamethasone modulates TCR zeta chain expression and antigen receptor-mediated early signaling events in human T lymphocytes. Cell Immunol 2001; 208: 62-71.
61. Wang L, Bronstein N, Hsu V, Baniyash M. Transcriptional regulation of the murine TCR zeta gene. Int Immunol 1995; 7: 1627-1635.
62. Stamatopoulos B, Meuleman N, Haibe-Kains B et al. Quantification of ZAP70 mRNA in B cells by real-time PCR is a powerful prognostic factor in chronic lymphocytic leukemia. Clin Chem 2007; 53: 1757-1766.
63. Whiteside TL. Down-regulation of zeta-chain expression in T cells: a biomarker of prognosis in cancer? Cancer Immunol Immunother 2004; 53: 865-878.