The design, synthesis, and anti-tumor mechanism study of N-phosphoryl amino acid modified resveratrol analogues

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 23, 2008, Pages 10013-10021

  Liu, Huachen ^a,b   Dong, Aijun ^b   Gao, Chunmei ^b   Tan, Chunyan ^b   Liu, Hongxia ^b   Zu, Xuyu ^b   Jiang, Yuyang ^b,c  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b Guangdong Province   (China)

^c Tsinghua University   (China)

Author keywords

Apoptosis; Mitochondrial pathway; N Phosphoryl amino acid; Resveratrol

Indexed keywords

AMINO ACID DERIVATIVE; CASPASE 3; CASPASE 9; FLUORESCEIN ISOTHIOCYANATE; LIPOCORTIN 5; N PHOSPHORYL AMINO ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROPIDIUM IODIDE; REACTIVE OXYGEN METABOLITE; RESVERATROL; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; DNA FRAGMENTATION; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MITOCHONDRION; NASOPHARYNX CARCINOMA; PROTEIN DEGRADATION; STAINING; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASES; DNA FRAGMENTATION; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; K562 CELLS; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; PHOSPHOAMINO ACIDS; STILBENES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 55749109699     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.10.022     Document Type: Article

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