Oligoarginine-based prodrugs with self-cleavable spacers for caco-2 cell permeation

Chemical and Pharmaceutical Bulletin

Volumn 56, Issue 11, 2008, Pages 1515-1520

  Takayama, Kentaro ^a,b   Suehisa, Yuka ^b   Fujita, Takuya ^b   Nguyen, Jeffrey Tri ^b   Futaki, Shiroh ^a,c   Yamamoto, Akira ^b   Kiso, Yoshiaki ^b   Hayashi, Yoshio ^b,d  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Cell penetrating peptide; Oligoarginine; Self cleavable spacer

Indexed keywords

ARGININE DERIVATIVE; ETHANOLAMINE; FLUORESCEIN ISOTHIOCYANATE; PRODRUG;

ACIDITY; ARTICLE; BIOTRANSFORMATION; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; CONFOCAL MICROSCOPY; CONJUGATE; ENDOCYTOSIS; ENDOSOME; FLOW CYTOMETRY; FLUORESCENCE; HALF LIFE TIME; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; INTESTINE ABSORPTION;

ARGININE; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; HALF-LIFE; HUMANS; HYDROGEN-ION CONCENTRATION; INDICATORS AND REAGENTS; MICROSCOPY, CONFOCAL; OLIGOPEPTIDES; PRODRUGS; SPECTROMETRY, FLUORESCENCE; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT;

EID: 55749104665     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.56.1515     Document Type: Article

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