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Volumn 10, Issue 3, 2008, Pages

Estrogen and progesterone induce persistent increases in p53-dependent apoptosis and suppress mammary tumors in BALB/c-Trp53+/- mice

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR; PLACEBO; PROGESTERONE; PROTEIN P53;

EID: 55749090657     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr2094     Document Type: Article
Times cited : (29)

References (52)
  • 2
    • 0035945656 scopus 로고    scopus 로고
    • Estrogen and the risk of breast cancer
    • 10.1056/NEJM200101253440407, 11172156
    • Clemons M, Goss P. Estrogen and the risk of breast cancer. N Engl J Med 2001, 344:276-285. 10.1056/NEJM200101253440407, 11172156.
    • (2001) N Engl J Med , vol.344 , pp. 276-285
    • Clemons, M.1    Goss, P.2
  • 3
    • 0041825575 scopus 로고    scopus 로고
    • Oestrogen exposure and breast cancer risk
    • 314432, 12927032, 10.1186/bcr628
    • Travis RC, Key TJ. Oestrogen exposure and breast cancer risk. Breast Cancer Res 2003, 5:239-247. 314432, 12927032, 10.1186/bcr628.
    • (2003) Breast Cancer Res , vol.5 , pp. 239-247
    • Travis, R.C.1    Key, T.J.2
  • 5
    • 0028229958 scopus 로고
    • Reproductive risk factors in a prospective study of breast cancer: the Nurses' Health Study
    • Rosner B, Colditz GA, Willett WC. Reproductive risk factors in a prospective study of breast cancer: the Nurses' Health Study. Am J Epidemiol 1994, 139:819-835.
    • (1994) Am J Epidemiol , vol.139 , pp. 819-835
    • Rosner, B.1    Colditz, G.A.2    Willett, W.C.3
  • 6
    • 0023943111 scopus 로고
    • Prevention of mammary carcinogenesis in rats by pregnancy: effect of full-term and interrupted pregnancy
    • Sinha DK, Pazik JE, Dao TL. Prevention of mammary carcinogenesis in rats by pregnancy: effect of full-term and interrupted pregnancy. Br J Cancer 1988, 57:390-394.
    • (1988) Br J Cancer , vol.57 , pp. 390-394
    • Sinha, D.K.1    Pazik, J.E.2    Dao, T.L.3
  • 8
    • 2442535038 scopus 로고    scopus 로고
    • Prepubertal estradiol and genistein exposures up-regulate BRCA1 mRNA and reduce mammary tumorigenesis
    • 10.1093/carcin/bgh065, 14729590
    • Cabanes A, Wang M, Olivo S, deAssis S, Gustafsson JA, Khan G, Hilakivi-Clarke L. Prepubertal estradiol and genistein exposures up-regulate BRCA1 mRNA and reduce mammary tumorigenesis. Carcinogenesis 2004, 25:741-748. 10.1093/carcin/bgh065, 14729590.
    • (2004) Carcinogenesis , vol.25 , pp. 741-748
    • Cabanes, A.1    Wang, M.2    Olivo, S.3    deAssis, S.4    Gustafsson, J.A.5    Khan, G.6    Hilakivi-Clarke, L.7
  • 9
    • 0021988073 scopus 로고
    • Chemoprevention of N-nitroso-N-methylurea-induced mammary cancers by pretreatment with 17 beta-estradiol and progesterone
    • Grubbs CJ, Farnell DR, Hill DL, McDonough KC. Chemoprevention of N-nitroso-N-methylurea-induced mammary cancers by pretreatment with 17 beta-estradiol and progesterone. J Natl Cancer Inst 1985, 74:927-931.
    • (1985) J Natl Cancer Inst , vol.74 , pp. 927-931
    • Grubbs, C.J.1    Farnell, D.R.2    Hill, D.L.3    McDonough, K.C.4
  • 11
    • 0028879918 scopus 로고
    • Refractoriness to mammary tumorigenesis in parous rats: is it caused by persistent changes in the hormonal environment or permanent biochemical alterations in the mammary epithelia?
    • 10.1093/carcin/16.11.2847, 7586208
    • Thordarson G, Jin E, Guzman RC, Swanson SM, Nandi S, Talamantes F. Refractoriness to mammary tumorigenesis in parous rats: is it caused by persistent changes in the hormonal environment or permanent biochemical alterations in the mammary epithelia?. Carcinogenesis 1995, 16:2847-2853. 10.1093/carcin/16.11.2847, 7586208.
    • (1995) Carcinogenesis , vol.16 , pp. 2847-2853
    • Thordarson, G.1    Jin, E.2    Guzman, R.C.3    Swanson, S.M.4    Nandi, S.5    Talamantes, F.6
  • 13
    • 33645860186 scopus 로고    scopus 로고
    • Reproductive experience reduces circulating 17beta-estradiol and prolactin levels during proestrus and alters estrogen sensitivity in female rats
    • 10.1210/en.2005-0917, 16484327
    • Bridges RS, Byrnes EM. Reproductive experience reduces circulating 17beta-estradiol and prolactin levels during proestrus and alters estrogen sensitivity in female rats. Endocrinology 2006, 147:2575-2582. 10.1210/en.2005-0917, 16484327.
    • (2006) Endocrinology , vol.147 , pp. 2575-2582
    • Bridges, R.S.1    Byrnes, E.M.2
  • 14
    • 0020328219 scopus 로고
    • Differentiation of the mammary gland and susceptibility to carcinogenesis
    • 10.1007/BF01805718, 6216933
    • Russo J, Tay LK, Russo IH. Differentiation of the mammary gland and susceptibility to carcinogenesis. Breast Cancer Res Treat 1982, 2:5-73. 10.1007/BF01805718, 6216933.
    • (1982) Breast Cancer Res Treat , vol.2 , pp. 5-73
    • Russo, J.1    Tay, L.K.2    Russo, I.H.3
  • 15
    • 0033515086 scopus 로고    scopus 로고
    • Hormonal prevention of breast cancer: mimicking the protective effect of pregnancy
    • 26817, 10051675, 10.1073/pnas.96.5.2520
    • Guzman RC, Yang J, Rajkumar L, Thordarson G, Chen X, Nandi S. Hormonal prevention of breast cancer: mimicking the protective effect of pregnancy. Proc Natl Acad Sci USA 1999, 96:2520-2525. 26817, 10051675, 10.1073/pnas.96.5.2520.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 2520-2525
    • Guzman, R.C.1    Yang, J.2    Rajkumar, L.3    Thordarson, G.4    Chen, X.5    Nandi, S.6
  • 16
    • 0038386685 scopus 로고    scopus 로고
    • Host microenvironment in breast cancer development: epithelial-cell-stromal-cell interactions and steroid hormone action in normal and cancerous mammary gland
    • 165024, 12817994, 10.1186/bcr615
    • Haslam SZ, Woodward TL. Host microenvironment in breast cancer development: epithelial-cell-stromal-cell interactions and steroid hormone action in normal and cancerous mammary gland. Breast Cancer Res 2003, 5:208-215. 165024, 12817994, 10.1186/bcr615.
    • (2003) Breast Cancer Res , vol.5 , pp. 208-215
    • Haslam, S.Z.1    Woodward, T.L.2
  • 17
    • 2342441403 scopus 로고    scopus 로고
    • The stroma as a crucial target in rat mammary gland carcinogenesis
    • 10.1242/jcs.01000, 14996910
    • Maffini MV, Soto AM, Calabro JM, Ucci AA, Sonnenschein C. The stroma as a crucial target in rat mammary gland carcinogenesis. J Cell Sci 2004, 117:1495-1502. 10.1242/jcs.01000, 14996910.
    • (2004) J Cell Sci , vol.117 , pp. 1495-1502
    • Maffini, M.V.1    Soto, A.M.2    Calabro, J.M.3    Ucci, A.A.4    Sonnenschein, C.5
  • 18
    • 33144465789 scopus 로고    scopus 로고
    • Remodeling of the mammary microenvironment after lactation promotes breast tumor cell metastasis
    • 1606507, 16436674, 10.2353/ajpath.2006.050677
    • McDaniel SM, Rumer KK, Biroc SL, Metz RP, Singh M, Porter W, Schedin P. Remodeling of the mammary microenvironment after lactation promotes breast tumor cell metastasis. Am J Pathol 2006, 168:608-620. 1606507, 16436674, 10.2353/ajpath.2006.050677.
    • (2006) Am J Pathol , vol.168 , pp. 608-620
    • McDaniel, S.M.1    Rumer, K.K.2    Biroc, S.L.3    Metz, R.P.4    Singh, M.5    Porter, W.6    Schedin, P.7
  • 19
    • 33745714220 scopus 로고    scopus 로고
    • Hormone-induced protection against mammary tumorigenesis is conserved in multiple rat strains and identifies a core gene expression signature induced by pregnancy
    • 10.1158/0008-5472.CAN-05-4235, 16778221
    • Blakely CM, Stoddard AJ, Belka GK, Dugan KD, Notarfrancesco KL, Moody SE, D'Cruz CM, Chodosh LA. Hormone-induced protection against mammary tumorigenesis is conserved in multiple rat strains and identifies a core gene expression signature induced by pregnancy. Cancer Res 2006, 66:6421-6431. 10.1158/0008-5472.CAN-05-4235, 16778221.
    • (2006) Cancer Res , vol.66 , pp. 6421-6431
    • Blakely, C.M.1    Stoddard, A.J.2    Belka, G.K.3    Dugan, K.D.4    Notarfrancesco, K.L.5    Moody, S.E.6    D'Cruz, C.M.7    Chodosh, L.A.8
  • 21
    • 0035940463 scopus 로고    scopus 로고
    • P53 is a potential mediator of pregnancy and hormone-induced resistance to mammary carcinogenesis
    • 60062, 11606748, 10.1073/pnas.221459098
    • Sivaraman L, Conneely OM, Medina D, O'Malley BW. p53 is a potential mediator of pregnancy and hormone-induced resistance to mammary carcinogenesis. Proc Natl Acad Sci USA 2001, 98:12379-12384. 60062, 11606748, 10.1073/pnas.221459098.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 12379-12384
    • Sivaraman, L.1    Conneely, O.M.2    Medina, D.3    O'Malley, B.W.4
  • 22
    • 0034696344 scopus 로고    scopus 로고
    • A mammary-specific model demonstrates the role of the p53 tumor suppressor gene in tumor development
    • 10.1038/sj.onc.1203270, 10713689
    • Jerry DJ, Kittrell FS, Kuperwasser C, Laucirica R, Dickinson ES, Bonilla PJ, Butel JS, Medina D. A mammary-specific model demonstrates the role of the p53 tumor suppressor gene in tumor development. Oncogene 2000, 19:1052-1058. 10.1038/sj.onc.1203270, 10713689.
    • (2000) Oncogene , vol.19 , pp. 1052-1058
    • Jerry, D.J.1    Kittrell, F.S.2    Kuperwasser, C.3    Laucirica, R.4    Dickinson, E.S.5    Bonilla, P.J.6    Butel, J.S.7    Medina, D.8
  • 23
    • 0141988721 scopus 로고    scopus 로고
    • P53 function is required for hormone-mediated protection of mouse mammary tumorigenesis
    • Medina D, Kittrell FS. p53 function is required for hormone-mediated protection of mouse mammary tumorigenesis. Cancer Res 2003, 63:6140-6143.
    • (2003) Cancer Res , vol.63 , pp. 6140-6143
    • Medina, D.1    Kittrell, F.S.2
  • 24
    • 0018831324 scopus 로고
    • Breast cancer risk from low-dose exposures to ionizing radiation: results of parallel analysis of three exposed populations of women
    • Land CE, Boice JDJ, Shore RE, Norman JE, Tokunaga M. Breast cancer risk from low-dose exposures to ionizing radiation: results of parallel analysis of three exposed populations of women. J Natl Cancer Inst 1980, 65:353-376.
    • (1980) J Natl Cancer Inst , vol.65 , pp. 353-376
    • Land, C.E.1    Boice, J.D.J.2    Shore, R.E.3    Norman, J.E.4    Tokunaga, M.5
  • 25
    • 0018575606 scopus 로고
    • Breast cancer among atomic bomb survivors: relationship of prognosis to pathologic findings
    • Tokunaga M. Breast cancer among atomic bomb survivors: relationship of prognosis to pathologic findings. Acta Pathol Jpn 1979, 29:197-209.
    • (1979) Acta Pathol Jpn , vol.29 , pp. 197-209
    • Tokunaga, M.1
  • 26
    • 0036337122 scopus 로고    scopus 로고
    • Epithelial cell cycling predicts p53 responsiveness to gamma-irradiation during post-natal mammary gland development
    • Minter LM, Dickinson ES, Naber SP, Jerry DJ. Epithelial cell cycling predicts p53 responsiveness to gamma-irradiation during post-natal mammary gland development. Development 2002, 129:2997-3008.
    • (2002) Development , vol.129 , pp. 2997-3008
    • Minter, L.M.1    Dickinson, E.S.2    Naber, S.P.3    Jerry, D.J.4
  • 27
    • 24144461028 scopus 로고    scopus 로고
    • Estrogen and progesterone regulate radiation-induced p53 activity in mammary epithelium through TGF-beta-dependent pathways
    • Becker KA, Lu S, Dickinson ES, Dunphy KA, Mathews L, Schneider SS, Jerry DJ. Estrogen and progesterone regulate radiation-induced p53 activity in mammary epithelium through TGF-beta-dependent pathways. Oncogene 2005, 24:6345-6353.
    • (2005) Oncogene , vol.24 , pp. 6345-6353
    • Becker, K.A.1    Lu, S.2    Dickinson, E.S.3    Dunphy, K.A.4    Mathews, L.5    Schneider, S.S.6    Jerry, D.J.7
  • 29
    • 0031031049 scopus 로고    scopus 로고
    • Tumors associated with p53 germline mutations: a synopsis of 91 families
    • 1858532, 9006316
    • Kleihues P, Schauble B, zur HA, Esteve J, Ohgaki H. Tumors associated with p53 germline mutations: a synopsis of 91 families. Am J Pathol 1997, 150:1-13. 1858532, 9006316.
    • (1997) Am J Pathol , vol.150 , pp. 1-13
    • Kleihues, P.1    Schauble, B.2    zur, H.A.3    Esteve, J.4    Ohgaki, H.5
  • 30
    • 1542546126 scopus 로고    scopus 로고
    • Preferential induction of mammary tumors in p53 hemizygous BALB/c mice by fractionated irradiation of a sub-lethal dose of X-rays
    • 10.1269/jrr.44.249, 14646229
    • Mori N, Yamate J, Umesako S, Hong DP, Okumoto M, Nakao R. Preferential induction of mammary tumors in p53 hemizygous BALB/c mice by fractionated irradiation of a sub-lethal dose of X-rays. J Radiat Res (Tokyo) 2003, 44:249-254. 10.1269/jrr.44.249, 14646229.
    • (2003) J Radiat Res (Tokyo) , vol.44 , pp. 249-254
    • Mori, N.1    Yamate, J.2    Umesako, S.3    Hong, D.P.4    Okumoto, M.5    Nakao, R.6
  • 33
    • 0036527761 scopus 로고    scopus 로고
    • Dissecting p53 tumor suppressor functions in vivo
    • 10.1016/S1535-6108(02)00047-8, 12086865
    • Schmitt CA, Fridman JS, Yang M, Baranov E, Hoffman RM, Lowe SW. Dissecting p53 tumor suppressor functions in vivo. Cancer Cell 2002, 1:289-298. 10.1016/S1535-6108(02)00047-8, 12086865.
    • (2002) Cancer Cell , vol.1 , pp. 289-298
    • Schmitt, C.A.1    Fridman, J.S.2    Yang, M.3    Baranov, E.4    Hoffman, R.M.5    Lowe, S.W.6
  • 34
    • 34248231386 scopus 로고    scopus 로고
    • Hormone-induced protection of mammary tumorigenesis in genetically engineered mouse models
    • 1851398, 17257424, 10.1186/bcr1645
    • Rajkumar L, Kittrell FS, Guzman RC, Brown PH, Nandi S, Medina D. Hormone-induced protection of mammary tumorigenesis in genetically engineered mouse models. Breast Cancer Res 2007, 9:R12. 1851398, 17257424, 10.1186/bcr1645.
    • (2007) Breast Cancer Res , vol.9
    • Rajkumar, L.1    Kittrell, F.S.2    Guzman, R.C.3    Brown, P.H.4    Nandi, S.5    Medina, D.6
  • 35
    • 33845611951 scopus 로고    scopus 로고
    • Modeling the therapeutic efficacy of p53 restoration in tumors
    • 10.1016/j.cell.2006.12.007, 17182091
    • Martins CP, Brown-Swigart L, Evan GI. Modeling the therapeutic efficacy of p53 restoration in tumors. Cell 2006, 127:1323-1334. 10.1016/j.cell.2006.12.007, 17182091.
    • (2006) Cell , vol.127 , pp. 1323-1334
    • Martins, C.P.1    Brown-Swigart, L.2    Evan, G.I.3
  • 36
    • 33846937033 scopus 로고    scopus 로고
    • Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
    • 10.1038/nature05529, 17251933
    • Xue W, Zender L, Miething C, Dickins RA, Hernando E, Krizhanovsky V, Cordon-Cardo C, Lowe SW. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 2007, 445:656-660. 10.1038/nature05529, 17251933.
    • (2007) Nature , vol.445 , pp. 656-660
    • Xue, W.1    Zender, L.2    Miething, C.3    Dickins, R.A.4    Hernando, E.5    Krizhanovsky, V.6    Cordon-Cardo, C.7    Lowe, S.W.8
  • 38
    • 33745020716 scopus 로고    scopus 로고
    • Loss of one p53 allele results in four-fold reduction of p53 mRNA and protein: a basis for p53 haplo-insufficiency
    • 10.1038/sj.onc.1209387, 16449974
    • Lynch CJ, Milner J. Loss of one p53 allele results in four-fold reduction of p53 mRNA and protein: a basis for p53 haplo-insufficiency. Oncogene 2006, 25:3463-3470. 10.1038/sj.onc.1209387, 16449974.
    • (2006) Oncogene , vol.25 , pp. 3463-3470
    • Lynch, C.J.1    Milner, J.2
  • 39
    • 2542432915 scopus 로고    scopus 로고
    • Haploinsufficiency for tumour suppressor genes: when you don't need to go all the way
    • Santarosa M, Ashworth A. Haploinsufficiency for tumour suppressor genes: when you don't need to go all the way. Biochim Biophys Acta 2004, 1654:105-122.
    • (2004) Biochim Biophys Acta , vol.1654 , pp. 105-122
    • Santarosa, M.1    Ashworth, A.2
  • 40
    • 33747109070 scopus 로고    scopus 로고
    • Reproductive factors and breast cancer risk according to joint estrogen and progesterone receptor status: a meta-analysis of epidemiological studies
    • 1779465, 16859501, 10.1186/bcr1525
    • Ma H, Bernstein L, Pike MC, Ursin G. Reproductive factors and breast cancer risk according to joint estrogen and progesterone receptor status: a meta-analysis of epidemiological studies. Breast Cancer Res 2006, 8:R43. 1779465, 16859501, 10.1186/bcr1525.
    • (2006) Breast Cancer Res , vol.8
    • Ma, H.1    Bernstein, L.2    Pike, M.C.3    Ursin, G.4
  • 41
    • 2442701845 scopus 로고    scopus 로고
    • Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasis
    • 10.1158/0008-5472.CAN-03-3524, 15150107
    • Lin SC, Lee KF, Nikitin AY, Hilsenbeck SG, Cardiff RD, Li A, Kang KW, Frank SA, Lee WH, Lee EY. Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasis. Cancer Res 2004, 64:3525-3532. 10.1158/0008-5472.CAN-03-3524, 15150107.
    • (2004) Cancer Res , vol.64 , pp. 3525-3532
    • Lin, S.C.1    Lee, K.F.2    Nikitin, A.Y.3    Hilsenbeck, S.G.4    Cardiff, R.D.5    Li, A.6    Kang, K.W.7    Frank, S.A.8    Lee, W.H.9    Lee, E.Y.10
  • 42
    • 23044467159 scopus 로고    scopus 로고
    • Opposite effects of estrogen receptors alpha and beta on MCF-7 sensitivity to the cytotoxic action of TNF and p53 activity
    • 10.1038/sj.onc.1208595, 15870704
    • Lewandowski SA, Thiery J, Jalil A, Leclercq G, Szczylik C, Chouaib S. Opposite effects of estrogen receptors alpha and beta on MCF-7 sensitivity to the cytotoxic action of TNF and p53 activity. Oncogene 2005, 24:4789-4798. 10.1038/sj.onc.1208595, 15870704.
    • (2005) Oncogene , vol.24 , pp. 4789-4798
    • Lewandowski, S.A.1    Thiery, J.2    Jalil, A.3    Leclercq, G.4    Szczylik, C.5    Chouaib, S.6
  • 43
    • 34548051074 scopus 로고    scopus 로고
    • Estrogen receptor alpha inhibits p53-mediated transcriptional repression: implications for the regulation of apoptosis
    • 10.1158/0008-5472.CAN-06-3724, 17699779
    • Sayeed A, Konduri SD, Liu W, Bansal S, Li F, Das GM. Estrogen receptor alpha inhibits p53-mediated transcriptional repression: implications for the regulation of apoptosis. Cancer Res 2007, 67:7746-7755. 10.1158/0008-5472.CAN-06-3724, 17699779.
    • (2007) Cancer Res , vol.67 , pp. 7746-7755
    • Sayeed, A.1    Konduri, S.D.2    Liu, W.3    Bansal, S.4    Li, F.5    Das, G.M.6
  • 44
    • 33846935226 scopus 로고    scopus 로고
    • Parity-induced mammary epithelial cells are multipotent and express cell surface markers associated with stem cells
    • 10.1016/j.ydbio.2006.12.017, 17222404
    • Matulka LA, Triplett AA, Wagner KU. Parity-induced mammary epithelial cells are multipotent and express cell surface markers associated with stem cells. Dev Biol 2007, 303:29-44. 10.1016/j.ydbio.2006.12.017, 17222404.
    • (2007) Dev Biol , vol.303 , pp. 29-44
    • Matulka, L.A.1    Triplett, A.A.2    Wagner, K.U.3
  • 45
    • 0036339643 scopus 로고    scopus 로고
    • An adjunct mammary epithelial cell population in parous females: its role in functional adaptation and tissue renewal
    • Wagner KU, Boulanger CA, Henry MD, Sgagias M, Hennighausen L, Smith GH. An adjunct mammary epithelial cell population in parous females: its role in functional adaptation and tissue renewal. Development 2002, 129:1377-1386.
    • (2002) Development , vol.129 , pp. 1377-1386
    • Wagner, K.U.1    Boulanger, C.A.2    Henry, M.D.3    Sgagias, M.4    Hennighausen, L.5    Smith, G.H.6
  • 46
    • 39149115079 scopus 로고    scopus 로고
    • Pregnancy and the risk of breast cancer
    • 10.1677/ERC-07-0137, 18045947
    • Britt K, Ashworth A, Smalley M. Pregnancy and the risk of breast cancer. Endocr Relat Cancer 2007, 14:907-933. 10.1677/ERC-07-0137, 18045947.
    • (2007) Endocr Relat Cancer , vol.14 , pp. 907-933
    • Britt, K.1    Ashworth, A.2    Smalley, M.3
  • 47
    • 0024513912 scopus 로고
    • New mammary epithelial and fibroblastic cell clones in coculture form structures competent to differentiate functionally
    • 2115403, 2466037, 10.1083/jcb.108.3.1127
    • Reichmann E, Ball R, Groner B, Friis RR. New mammary epithelial and fibroblastic cell clones in coculture form structures competent to differentiate functionally. J Cell Biol 1989, 108:1127-1138. 2115403, 2466037, 10.1083/jcb.108.3.1127.
    • (1989) J Cell Biol , vol.108 , pp. 1127-1138
    • Reichmann, E.1    Ball, R.2    Groner, B.3    Friis, R.R.4
  • 48
    • 0021304613 scopus 로고
    • Interaction of rat mammary epithelium with extracellular matrix components
    • Wicha MS. Interaction of rat mammary epithelium with extracellular matrix components. Prog Clin Biol Res 1984, 145:129-142.
    • (1984) Prog Clin Biol Res , vol.145 , pp. 129-142
    • Wicha, M.S.1
  • 49
    • 27544510187 scopus 로고    scopus 로고
    • Stromal regulation of neoplastic development: age-dependent normalization of neoplastic mammary cells by mammary stroma
    • 1603788, 16251424
    • Maffini MV, Calabro JM, Soto AM, Sonnenschein C. Stromal regulation of neoplastic development: age-dependent normalization of neoplastic mammary cells by mammary stroma. Am J Pathol 2005, 167:1405-1410. 1603788, 16251424.
    • (2005) Am J Pathol , vol.167 , pp. 1405-1410
    • Maffini, M.V.1    Calabro, J.M.2    Soto, A.M.3    Sonnenschein, C.4
  • 50
  • 51
    • 85047683109 scopus 로고    scopus 로고
    • Fibronectin and the alpha(5)beta(1) integrin are under developmental and ovarian steroid regulation in the normal mouse mammary gland
    • 10.1210/en.142.7.3214, 11416044
    • Woodward TL, Mienaltowski AS, Modi RR, Bennett JM, Haslam SZ. Fibronectin and the alpha(5)beta(1) integrin are under developmental and ovarian steroid regulation in the normal mouse mammary gland. Endocrinology 2001, 142:3214-3222. 10.1210/en.142.7.3214, 11416044.
    • (2001) Endocrinology , vol.142 , pp. 3214-3222
    • Woodward, T.L.1    Mienaltowski, A.S.2    Modi, R.R.3    Bennett, J.M.4    Haslam, S.Z.5
  • 52
    • 0034986471 scopus 로고    scopus 로고
    • Growth defects induced by perturbation of beta1-integrin function in the mammary gland epithelium result from a lack of MAPK activation via the Shc and Akt pathways
    • 1083881, 11375936
    • Faraldo MM, Deugnier MA, Thiery JP, Glukhova MA. Growth defects induced by perturbation of beta1-integrin function in the mammary gland epithelium result from a lack of MAPK activation via the Shc and Akt pathways. EMBO Rep 2001, 2:431-437. 1083881, 11375936.
    • (2001) EMBO Rep , vol.2 , pp. 431-437
    • Faraldo, M.M.1    Deugnier, M.A.2    Thiery, J.P.3    Glukhova, M.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.