Methylation-related silencing of p14ARF gene correlates with telomerase activity and mRNA expression of human telomerase reverse transcriptase in hepatocellular carcinoma

Journal of Surgical Oncology

Volumn 98, Issue 6, 2008, Pages 462-468

  Zhang, Changsong ^a,b   Guo, Xianling ^a   Zhang, Li ^a   Lu, Zhenghua ^a   Ma, Nannan ^a   Cheng, Yue ^a   Shen, Feng ^a   Zhang, Baihe ^a   Wu, Mengchao ^a   Wei, Lixin ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b China   (China)

Author keywords

Hepatocarcinoma; hTERT; Methylation; p14ARF; Telomerase

Indexed keywords

MESSENGER RNA; TELOMERASE REVERSE TRANSCRIPTASE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYCLIN DEPENDENT KINASE INHIBITOR 2A GENE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE; GENE EXPRESSION; GENE SILENCING; HUMAN; LIVER CELL CARCINOMA; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METHYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE; TUMOR VOLUME;

ADULT; AGED; CARCINOMA, HEPATOCELLULAR; DNA METHYLATION; FEMALE; GENE SILENCING; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TELOMERASE; TUMOR SUPPRESSOR PROTEIN P14ARF;

EID: 55749089203     PISSN: 00224790     EISSN: 10969098     Source Type: Journal    
DOI: 10.1002/jso.21131     Document Type: Article

References (36)

1. Schafer DF, Sorrell MF: Hepatocellular carcinoma. Lancet 1999;353:1253-1257.
2. Nobori T, Miura K, Wu DJ, et al.: Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature 1994;368:753-756.
3. Chin L, Pomerantz J, DePinho RA: The INK4a/ARF tumor suppressor: One gene - Two products - Two pathways. Trends Biochem Sci 1998;23:291-296.
4. Zhang Y, Xiong Y, Yarbrough WG: ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 1998;92:725-734.
5. Agrawal A, Yang J, Murphy RF, et al.: Regulation of the p14ARF-Mdm2-p53 pathway: An overview in breast cancer. Exp Mol Pathol 2006;81:115-122.
6. Sharpless NE: INK4a/ARF: A multifunctional tumor suppressor locus. Mutat Res 2005;576:22-38.
7. Robertson KD: DNA methylation and human disease. Nat Rev Genet 2005;6:597-610.
8. Badal V, Menendez S, Coomber D, et al.: Regulation of the p14ARF promoter by DNA methylation. Cell Cycle 2008;7:112-119.
9. Cairney CJ, Keith WN: Telomerase redefined: Integrated regulation of hTR and hTERT for telomere maintenance and telomerase activity. Biochimie 2008;90:13-23.
10. Shay JW, Bacchetti S: A survey of telomerase activity in human cancer. Eur J Cancer 1997;33:787-791.
11. Feng J, Funk WD, Wang SS, et al.: The RNA component of human telomerase. Science 1995;269:1236-1241.
12. De Cian A, Lacroix L, Douarre C, et al.: Targeting telomeres and telomerase. Biochimie 2008;90:131-155.
13. Oh BK, Kim H, Park YN, et al.: High telomerase activity and long telomeres in advanced hepatocellular carcinomas with poor prognosis. Lab Invest 2008;88:144-152.
14. Kim NW, Piatyszek MA, Prowse KR, et al.: Specific association of human telomerase activity with immortal cells and cancer. Science 1994;266:2011-2015.
15. Farwell DG, Shera KA, Koop JI, et al.: Genetic and epigenetic changes in human epithelial cells immortalized by telomerase. Am J Pathol 2000;156:1537-1547.
16. Rahman R, Latonen L, Wiman KG: hTERT antagonizes p53-induced apoptosis independently of telomerase activity. Oncogene 2005;24:1320-1327.
17. Shats I, Milyavsky M, Tang X, et al.: p53-dependent downregulation of telomerase is mediated by p21waf1. J Biol Chem 2004;279:50976-50985.
18. Edmondson HA, Steiner PE: Primary carcinoma of the liver: A study of 100 cases among 48,900 necropsies. Cancer 1954;7:462-503.
19. Herman JG, Graff JR, Myohanen S, et al.: Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 1996;93:9821-9826.
20. Esteller M, Tortola S, Toyota M, et al.: Hypermethylationa-ssociated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status. Cancer Res 2000;60:129-133.
21. Wang S, Zhu J: Evidence for a relief of repression mechanism for activation of the human telomerase reverse transcriptase promoter. J Biol Chem 2003;278:18842-18850.
22. Kim NW, Wu F: Advances in quantification and characterization of telomerase activity by the telomeric repeat amplification protocol (TRAP). Nucleic Acids Res 1997;25:2595-2597.
23. Bosch FX, Ribes J, Borras J: Epidemiology of primary liver cancer. Semin Liver Dis 1999;19:271-285.
24. Tannapfel A, Busse C, Weinans L, et al.: INK4a-ARF alterations and p53 mutations in hepatocellular carcinomas. Oncogene 2001;20:7104-7109.
25. Herath NI, Kew MC, Walsh MD, et al.: Reciprocal relationship between methylation status and loss of heterozygosity at the p14(ARF) locus in Australian and South African hepatocellular carcinomas. J Gastroenterol Hepatol 2002;17:301-307.
26. Kondo Y, Kanai Y, Sakamoto M, et al.: Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis - A comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma. Hepatology 2000;32:970-979.
27. Brechot C, Pourcel C, Louise A, et al.: Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma. Nature 1980;286:533-535.
28. Doerfler W: The insertion of foreign DNA into mammalian genomes and its consequences: A concept in oncogenesis. Adv Cancer Res 1995;66:313-344.
29. Heller H, Kammer C, Wilgenbus P, et al.: Chromosomal insertion of foreign (adenovirus type 12, plasmid, or bacteriophage lambda) DNA is associated with enhanced methylation of cellular DNA segments. Proc Natl Acad Sci USA 1995;92:5515-5519.
30. Remus R, Kammer C, Heller H, et al.: Insertion of foreign DNA into an established mammalian genome can alter the methylation of cellular DNA sequences. J Virol 1999;73:1010-1022.
31. Lowe SW, Sherr CJ: Tumor suppression by Ink4a-Arf: Progress and puzzles. Curr Opin Genet Dev 2003;13:77-83.
32. Voorhoeve PM, Agami R: Unraveling human tumor suppressor pathways: A tale of the INK4A locus. Cell Cycle 2004;3:616-620.
33. Li H, Cao Y, Berndt MC, et al.: Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro. Oncogene 1999;18:6785-6794.
34. Shamanin VA, Androphy EJ: Immortalization of human mammary epithelial cells is associated with inactivation of the p14ARF-p53 pathway. Mol Cell Biol 2004;24:2144-2152.
35. Shao JC, Wu JF, Wang DB, et al.: Relationship between the expression of human telomerase reverse transcriptase gene and cell cycle regulators in gastric cancer and its significance. World J Gastroenterol 2003;9:427-431.
36. ARF-p53 pathway induced by methylation in HCC ->Synopsis for Table of Contents.