Role of MDR1 gene polymorphisms in gingival overgrowth induced by cyclosporine in transplant patients

Journal of Periodontal Research

Volumn 43, Issue 6, 2008, Pages 665-672

  De Iudicibus, S ^a,b   Castronovo, G ^a   Gigante, A ^a   Stocco, G ^a,b   Decorti, G ^a   Di Lenarda, R ^a   Bartoli, F ^b  

^a UNIVERSITY OF TRIESTE   (Italy)

^b INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

Author keywords

Cyclosporine A; Gingival overgrowth; MDR1 gene polymorphisms; Non surgical aetiological periodontal therapy

Indexed keywords

AMOXICILLIN; ANTIINFECTIVE AGENT; CLARITHROMYCIN; CYCLOSPORIN; GLYCOPROTEIN P; IMMUNOSUPPRESSIVE AGENT;

ARTICLE; BIOSYNTHESIS; CASE CONTROL STUDY; CHEMICALLY INDUCED DISORDER; FEMALE; GENETICS; GINGIVA OVERGROWTH; HEART TRANSPLANTATION; HUMAN; KIDNEY TRANSPLANTATION; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; MISSENSE MUTATION; MOUTH HYGIENE; PREVENTIVE DENTISTRY; PROSPECTIVE STUDY; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL MODEL;

AMOXICILLIN; ANTI-BACTERIAL AGENTS; CASE-CONTROL STUDIES; CLARITHROMYCIN; CYCLOSPORINE; DENTAL SCALING; FEMALE; GINGIVAL OVERGROWTH; HEART TRANSPLANTATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; LIVER TRANSPLANTATION; LOGISTIC MODELS; MALE; MIDDLE AGED; MUTATION, MISSENSE; ORAL HYGIENE; P-GLYCOPROTEIN; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES;

EID: 55649102271     PISSN: 00223484     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0765.2008.01068.x     Document Type: Article

References (41)

1. King GN, Fullinfaw R, Higgins TJ, Walker RG, Francis DM, Wiesenfeld D. Gingival hyperplasia in renal allograft recipients receiving cyclosporin-A and calcium antagonists. J Clin Periodontol 1993 20 : 286 293.
2. Hefti AF, Eshenaur AE, Hassell TM, Stone C. Gingival overgrowth in cyclosporine A treated multiple sclerosis patients. J Periodontol 1994 65 : 744 749.
3. Boltchi FE, Rees TD, Iacopino AM. Cyclosporine A-induced gingival overgrowth: a comprehensive review. Quintessence Int 1999 30 : 775 783.
4. Afonso M, Bello Vde O, Shibli JA, Sposto MR. Cyclosporin A-induced gingival overgrowth in renal transplant patients. J Periodontol 2003 74 : 51 56.
5. Seymour RA, Heasman PA. Drugs and the periodontium. J Clin Periodontol 1988 15 : 1 16.
6. Montebugnoli L, Servidio D, Bernardi F. The role of time in reducing gingival overgrowth in heart-transplanted patients following cyclosporin therapy. J Clin Periodontol 2000 27 : 611 614.
7. Wondimu B, Sandberg J, Modeer T. Gingival overgrowth in renal transplant patients administered cyclosporin A in mixture or in capsule form. A longitudinal study. Clin Transplant 1996 10 : 71 76.
8. Wilson RF, Morel A, Smith D et al. Contribution of individual drugs to gingival overgrowth in adult and juvenile renal transplant patients treated with multiple therapy. J Clin Periodontol 1998 25 : 457 464.
9. Thomason JM, Seymour RA, Ellis JS. Risk factors for gingival overgrowth in patients medicated with ciclosporin in the absence of calcium channel blockers. J Clin Periodontol 2005 32 : 273 279.
10. Ciavarella D, Guiglia R, Campisi G et al. Update on gingival overgrowth by cyclosporine A in renal transplants. Med Oral Patol Oral Cir Bucal 2007 12 : E19 25.
11. Rostock MH, Fry HR, Turner JE. Severe gingival overgrowth associated with cyclosporine therapy. J Periodontol 1986 57 : 294 299.
12. Seymour RA, Smith DG, Rogers SR. The comparative effects of azathioprine and cyclosporin on some gingival health parameters of renal transplant patients. A longitudinal study. J Clin Periodontol 1987 14 : 610 613.
13. Daley TD, Wysocki GP, Day C. Clinical and pharmacologic correlations in cyclosporine-induced gingival hyperplasia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1986 62 : 417 421.
14. Daley TD, Wysocki GP. Cyclosporine therapy. Its significance to the periodontist. J Periodontol 1984 55 : 708 712.
15. Seymour RA, Thomason JM, Ellis JS. The pathogenesis of drug-induced gingival overgrowth. J Clin Periodontol 1996 23 : 165 175.
16. Drozdzik M, Mysliwiec K, Lewinska-Chelstowska M, Banach J, Drozdzik A, Grabarek J. P-glycoprotein drug transporter MDR1 gene polymorphism in renal transplant patients with and without gingival overgrowth. J Clin Periodontol 2004 31 : 758 763.
17. Meisel P, Giebel J, Kunert-Keil C, Dazert P, Kroemer HK, Kocher T. MDR1 gene polymorphisms and risk of gingival hyperplasia induced by calcium antagonists. Clin Pharmacol Ther 2006 79 : 62 71.
18. Hoffmeyer S, Burk O, vonRichter O et al. Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci USA 2000 97 : 3473 3478.
19. Kerb R. Implications of genetic polymorphisms in drug transporters for pharmacotherapy. Cancer Lett 2006 234 : 4 33.
20. O'Leary T. Indices for measurement of tooth mobility in clinical studies. J Periodontal Res 1974 14 : 94 105.
21. Ainamo J, Bay I. Problems and proposals for recording gingivitis and plaque. Int Dent J 1975 25 : 229 235.
22. Seymour RA, Smith DG, Turnbull DN. The effects of phenytoin and sodium valproate on the periodontal health of adult epileptic patients. J Clin Periodontol 1985 12 : 413 419.
23. Seymour RA, Smith DG. The effect of a plaque control programme on the incidence and severity of cyclosporin-induced gingival changes. J Clin Periodontol 1991 18 : 107 110.
24. Cascorbi I, Gerloff T, Johne A et al. Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects. Clin Pharmacol Ther 2001 69 : 169 174.
25. Cnaan A, Laird NM, Slasor P. Using the general linear mixed model to analyse unbalanced repeated measures and longitudinal data. Stat Med 1997 16 : 2349 2380.
26. Somacarrera ML, Hernandez G, Acero J, Moskow BS. Factors related to the incidence and severity of cyclosporin-induced gingival overgrowth in transplant patients. A longitudinal study. J Periodontol 1994 65 : 671 675.
27. Margiotta V, Pizzo I, Pizzo G, Barbaro A. Cyclosporin- and nifedipine-induced gingival overgrowth in renal transplant patients: correlations with periodontal and pharmacological parameters, and HLA-antigens. J Oral Pathol Med 1996 25 : 128 134.
28. Miranda J, Brunet L, Roset P, Berini L, Farre M, Mendieta C. Prevalence and risk of gingival enlargement in patients treated with nifedipine. J Periodontol 2001 72 : 605 611.
29. Miller CS, Damm DD. Incidence of verapamil-induced gingival hyperplasia in a dental population. J Periodontol 1992 63 : 453 456.
30. Bullon P, Machuca G, Martinez Sahuquillo A et al. Clinical assessment of gingival size among patients treated with diltiazem. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995 79 : 300 304.
31. Hassell TM, Hefti AF. Drug-induced gingival overgrowth: old problem, new problem. Crit Rev Oral Biol Med 1991 2 : 103 137.
32. Lowry LY, Welbury RR, Seymour RA, Waterhouse PJ, Hamilton JR. Gingival overgrowth in paediatric cardiac transplant patients: a study of 19 patients aged between 2 and 16 years. Int J Paediatr Dent 1995 5 : 217 222.
33. Foxwell BM, Mackie A, Ling V, Ryffel B. Identification of the multidrug resistance-related P-glycoprotein as a cyclosporine binding protein. Mol Pharmacol 1989 36 : 543 546.
34. Hennessy M, Spiers JP. A primer on the mechanics of P-glycoprotein the multidrug transporter. Pharmacol Res 2007 55 : 1 15.
35. Kerb R, Hoffmeyer S, Brinkmann U. ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2. Pharmacogenomics 2001 2 : 51 64.
36. Kimchi-Sarfaty C, Oh JM, Kim IW et al. A "silent" polymorphism in the MDR1 gene changes substrate specificity. Science 2007 315 : 525 528.
37. Tanabe M, Ieiri I, Nagata N et al. Expression of P-glycoprotein in human placenta: relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene. J Pharmacol Exp Ther 2001 297 : 1137 1143.
38. McGaw T, Lam S, Coates J. Cyclosporin-induced gingival overgrowth: correlation with dental plaque scores, gingivitis scores, and cyclosporin levels in serum and saliva. Oral Surg Oral Med Oral Pathol 1987 64 : 293 297.
39. Annese V, Valvano MR, Palmieri O, Latiano A, Bossa F, Andriulli A. Multidrug resistance 1 gene in inflammatory bowel disease: a meta-analysis. World J Gastroenterol 2006 12 : 3636 3644.
40. Ilgenli T, Atilla G, Baylas H. Effectiveness of periodontal therapy in patients with drug-induced gingival overgrowth. Long-term results. J Periodontol 1999 70 : 967 972.
41. Pernu HE, Pernu LM, Knuuttila ML, Huttunen KR. Gingival overgrowth among renal transplant recipients and uraemic patients. Nephrol Dial Transplant 1993 8 : 1254 1258.