2-Aminobenzimidazoles as potent ITK antagonists: trans-stilbene-like moieties targeting the kinase specificity pocket

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 23, 2008, Pages 6218-6221

  Lo, Ho Yin ^a   Bentzien, Jörg ^a   Fleck, Roman W ^a   Pullen, Steven S ^a   Khine, Hnin Hnin ^a   Woska Jr , Joseph R ^a   Kugler, Stanley Z ^a   Kashem, Mohammed A ^a   Takahashi, Hidenori ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

Aminobenzimidazoles; Inflammation; ITK; Kinase specificity pocket; T cell kinase

Indexed keywords

2 AMINOBENZIMIDAZOLE DERIVATIVE; BENZIMIDAZOLE DERIVATIVE; ENZYME INHIBITOR; INTERLEUKIN 2 INDUCIBLE T CELL KINASE; PROTEIN TYROSINE KINASE; STILBENE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOLECULAR MODEL; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

BENZIMIDAZOLES; COMBINATORIAL CHEMISTRY TECHNIQUES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; MOLECULAR STRUCTURE; PROTEIN-TYROSINE KINASES; STEREOISOMERISM; STILBENES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 55649090771     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.09.098     Document Type: Article

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