Allele-specific silencing of the dominant disease allele in sialuria by RNA interference

FASEB Journal

Volumn 22, Issue 11, 2008, Pages 3846-3852

  Klootwijk, Riko D ^a,d   Savelkoul, Paul J M ^a   Ciccone, Carla ^a   Manoli, Irini ^a   Caplen, Natasha J ^b   Krasnewich, Donna M ^a   Gahl, William A ^a,c   Huizing, Marjan ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

Allosteric site; Feedback inhibition; Real time PCR; Sialic acid; siRNA; UDP GlcNAc 2 epimerase ManNac kinase

Indexed keywords

CREATININE; EPIMERASE; PROTEIN; SIALIC ACID;

ADOLESCENT; ALLELE; ARTICLE; BINDING SITE; BIOSYNTHESIS; CASE REPORT; CELL CULTURE; DOMINANT GENE; DOWN REGULATION; FEMALE; FIBROBLAST; GENE; GENE MUTATION; GENE SILENCING; GENETIC TRANSFECTION; GNE GENE; HUMAN; HUMAN CELL; METABOLIC DISORDER; MISSENSE MUTATION; NEGATIVE FEEDBACK; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIALIC ACID URINE LEVEL; URINARY EXCRETION;

ALLELES; AMINO ACID SUBSTITUTION; CELLS, CULTURED; CYTIDINE MONOPHOSPHATE N-ACETYLNEURAMINIC ACID; FIBROBLASTS; GENES, DOMINANT; HUMANS; MULTIENZYME COMPLEXES; MUTATION, MISSENSE; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIALIC ACID STORAGE DISEASE;

EID: 55549138740     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.08-110890     Document Type: Article

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