Investigation of the role of SREBP-1c in the pathogenesis of HCV-related steatosis

Journal of Hepatology

Volumn 49, Issue 6, 2008, Pages 1046-1054

  McPherson, Stuart ^a,b,c   Jonsson, Julie R ^b   Barrie, Helen D ^b   O'Rourke, Peter ^d   Clouston, Andrew D ^b   Powell, Elizabeth E ^a,b  

^a PRINCESS ALEXANDRA HOSPITAL   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

de novo lipogenesis; Fatty acid synthase; Glycerol 3 phosphate acyltransferase; Insulin resistance; Microsomal triglyceride transfer protein

Indexed keywords

FATTY ACID SYNTHASE; GLYCEROL 3 PHOSPHATE ACYLTRANSFERASE; MESSENGER RNA; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C;

ADULT; ARTICLE; CHOLECYSTECTOMY; CONTROLLED STUDY; FATTY LIVER; FEMALE; GENE SEQUENCE; GENOTYPE; HEPATITIS; HEPATITIS C VIRUS; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER BIOPSY; LIVER FIBROSIS; LIVER METASTASIS; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; NUCLEOTIDE SEQUENCE; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ADULT; CARRIER PROTEINS; FATTY ACID SYNTHETASE COMPLEX; FATTY LIVER; FEMALE; GENE EXPRESSION; GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE; HEPATITIS C, CHRONIC; HUMANS; IMMUNOHISTOCHEMISTRY; INSULIN RESISTANCE; LIPOGENESIS; MALE; RNA, MESSENGER; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

EID: 55549107478     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2008.06.022     Document Type: Article

References (43)

1. WHO. Global surveillance and control of hepatitis C. Report of a WHO Consultation organized in collaboration with the Viral Hepatitis Prevention Board, Antwerp, Belgium. J Viral Hepat 1999;6:35-47.
2. Leandro G., Mangia A., Hui J., Fabris P., Rubbia-Brandt L., Colloredo G., et al. Relationship between steatosis, inflammation, and fibrosis in chronic hepatitis C: a meta-analysis of individual patient data. Gastroenterology 130 (2006) 1636-1642
3. Lonardo A., Adinolfi L.E., Loria P., Carulli N., Ruggiero G., and Day C.P. Steatosis and hepatitis C virus: mechanisms and significance for hepatic and extrahepatic disease. Gastroenterology 126 (2004) 586-597
4. Mihm S., Fayyazi A., Hartmann H., and Ramadori G. Analysis of histopathological manifestations of chronic hepatitis C virus infection with respect to virus genotype. Hepatology 25 (1997) 735-739
5. Rubbia-Brandt L., Quadri R., Abid K., Giostra E., Male P.J., Mentha G., et al. Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3. J Hepatol 33 (2000) 106-115
6. Adinolfi L., Gambardella M., Andreana A., Tripodi M.-F., Utili R., and Ruggiero G. Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity. Hepatology 33 (2001) 1358-1364
7. Hourigan L., Macdonald G., Purdie D., Whitehall V., Shorthouse C., Clouston A., et al. Fibrosis in chronic hepatitis C correlates significantly with body mass index and steatosis. Hepatology 29 (1999) 1215-1219
8. Powell E.E., Jonsson J.R., and Clouston A.D. Steatosis: co-factor in other liver diseases. Hepatology 42 (2005) 5-13
9. Negro F. Mechanisms and significance of liver steatosis in hepatitis C virus infection. World J Gastroenterol 12 (2006) 6756-6765
10. Moriya K., Yotsuyanagi H., Shintani Y., Fujie H., Ishibashi K., Matsuura Y., et al. Hepatitis C virus core protein induces hepatic steatosis in transgenic mice. J Gen Virol 78 (1997) 1527-1531
11. Barba G., Harper F., Harada T., Kohara M., Goulinet S., Matsuura Y., et al. Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets. PNAS 94 (1997) 1200-1205
12. Abid K., Pazienza V., de Gottardi A., Rubbia-Brandt L., Conne B., Pugnale P., et al. An in vitro model of hepatitis C virus genotype 3a-associated triglycerides accumulation. J Hepatol 42 (2005) 744-751
13. Mirandola S., Realdon S., Iqbal J., Gerotto M., Dal Pero F., Bortoletto G., et al. Liver microsomal triglyceride transfer protein is involved in hepatitis C liver steatosis. Gastroenterology 130 (2006) 1661-1669
14. Ferre P., and Foufelle F. SREBP-1c transcription factor and lipid homeostasis: clinical perspective. Horm Res 68 (2007) 72-82
15. Eberle D., Hegarty B., Bossard P., Ferre P., and Foufelle F. SREBP transcription factors: master regulators of lipid homeostasis. Biochimie 86 (2004) 839-848
16. Horton J.D., Goldstein J.L., and Brown M.S. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109 (2002) 1125-1131
17. Hua X., Wu J., Goldstein J.L., Brown M.S., and Hobbs H.H. Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13. Genomics 25 (1995) 667-673
18. Shimomura I., Shimano H., Horton J.D., Goldstein J.L., and Brown M.S. Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. J Clin Invest 99 (1997) 838-845
19. Su A.I., Pezacki J.P., Wodicka L., Brideau A.D., Supekova L., Thimme R., et al. Genomic analysis of the host response to hepatitis C virus infection. Proc Natl Acad Sci USA 99 (2002) 15669-15674
20. Kim K.H., Hong S.P., Kim K., Park M.J., Kim K.J., and Cheong J. HCV core protein induces hepatic lipid accumulation by activating SREBP1 and PPARgamma. Biochem Biophys Res Commun 355 (2007) 883-888
21. Jackel-Cram C., Babiuk L.A., and Liu Q. Up-regulation of fatty acid synthase promoter by hepatitis C virus core protein: genotype-3a core has a stronger effect than genotype-1b core. J Hepatol 46 (2007) 999-1008
22. Fukasawa M., Tanaka Y., Sato S., Ono Y., Nitahara-Kasahara Y., Suzuki T., et al. Enhancement of de novo fatty acid biosynthesis in hepatic cell line Huh7 expressing hepatitis C virus core protein. Biol Pharm Bull 29 (2006) 1958-1961
23. Waris G., Felmlee D.J., Negro F., and Siddiqui A. Hepatitis C virus induces proteolytic cleavage of sterol regulatory element binding proteins and stimulates their phosphorylation via oxidative stress. J Virol 81 (2007) 8122-8130
24. Ishak K., Baptista A., Bianchi L., Callea F., De Groote J., Gudat F., et al. Histological grading and staging of chronic hepatitis. J Hepatol 22 (1995) 696-699
25. Scheuer P.J. Classification of chronic viral hepatitis: a need for reassessment. J Hepatol 13 (1991) 372-374
26. Fleige S., and Pfaffl M.W. RNA integrity and the effect on the real-time qRT-PCR performance. Mol Aspects Med 27 (2006) 126-139
27. Walsh M., Vanags D., Clouston A., Richardson M., Purdie D., Jonsson J., et al. Steatosis and liver cell apoptosis in chronic hepatitis C: a mechanism for increased liver injury. Hepatology 39 (2004) 1230-1238
28. Jonsson J.R., Barrie H.D., O'Rourke P., Clouston A.D., and Powell E.E. Obesity and steatosis influence serum and hepatic inflammatory markers in chronic hepatitis C. Hepatology 48 (2008) 80-87
29. Matthews D.R., Hosker J.P., Rudenski A.S., Naylor B.A., Treacher D.F., and Turner R.C. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28 (1985) 412-419
30. Poynard T., Ratziu V., McHutchison J., Manns M., Goodman Z., Zeuzem S., et al. Effect of treatment with peginterferon or interferon alfa-2b and ribavirin on steatosis in patients infected with hepatitis C. Hepatology 38 (2003) 75-85
31. Bigger C.B., Guerra B., Brasky K.M., Hubbard G., Beard M.R., Luxon B.A., et al. Intrahepatic gene expression during chronic hepatitis C virus infection in chimpanzees. J Virol 78 (2004) 13779-13792
32. Horton J.D., Bashmakov Y., Shimomura I., and Shimano H. Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice. Proc Natl Acad Sci USA 95 (1998) 5987-5992
33. Shimomura I., Bashmakov Y., and Horton J.D. Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. J Biol Chem 274 (1999) 30028-30032
34. Yahagi N., Shimano H., Hasty A.H., Matsuzaka T., Ide T., Yoshikawa T., et al. Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice. J Biol Chem 277 (2002) 19353-19357
35. Xu J., Nakamura M.T., Cho H.P., and Clarke S.D. Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats. J Biol Chem 274 (1999) 23577-23583
36. Zhou G., Myers R., Li Y., Chen Y., Shen X., Fenyk-Melody J., et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 108 (2001) 1167-1174
37. Long Y.C., and Zierath J.R. AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest 116 (2006) 1776-1783
38. Sul H.S., and Wang D. Nutritional and hormonal regulation of enzymes in fat synthesis: studies of fatty acid synthase and mitochondrial glycerol-3-phosphate acyltransferase gene transcription. Annu Rev Nutr 18 (1998) 331-351
39. Denechaud P.D., Dentin R., Girard J., and Postic C. Role of ChREBP in hepatic steatosis and insulin resistance. FEBS Lett 582 (2008) 68-73
40. Field F.J., Born E., Murthy S., and Mathur S.N. Polyunsaturated fatty acids decrease the expression of sterol regulatory element-binding protein-1 in CaCo-2 cells: effect on fatty acid synthesis and triacylglycerol transport. Biochem J 368 (2002) 855-864
41. Yin J.L., Shackel N.A., Zekry A., McGuinness P.H., Richards C., Putten K.V., et al. Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) for measurement of cytokine and growth factor mRNA expression with fluorogenic probes or SYBR Green I. Immunol Cell Biol 79 (2001) 213-221
42. Dheda K., Huggett J.F., Chang J.S., Kim L.U., Bustin S.A., Johnson M.A., et al. The implications of using an inappropriate reference gene for real-time reverse transcription PCR data normalization. Anal Biochem 344 (2005) 141-143
43. Ding R., Medeiros M., Dadhania D., Muthukumar T., Kracker D., Kong J.M., et al. Noninvasive diagnosis of BK virus nephritis by measurement of messenger RNA for BK virus VP1 in urine. Transplantation 74 (2002) 987-994