Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 13, 2008, Pages 3682-3686

  Zhang, Mingzhu ^a   Jovic, Florence ^a   Vickers, Troy ^a   Dyck, Brian ^a   Tamiya, Junko ^a   Grey, Jonathan ^a   Tran, Joe A ^a   Fleck, Beth A ^a   Pick, Rebecca ^a   Foster, Alan C ^a   Chen, Chen ^a  

^a NEUROCRINE BIOSCIENCES INC   (United States)

Author keywords

Bicifadine; Inhibitor; Monoamine transporters; Pain; Potency; Selectivity; Structure activity relationship

Indexed keywords

ALUMINUM; ATOMOXETINE; BICIFADINE; BORONIC ACID DERIVATIVE; BROMIDE; DOV 102667; DOV 216303; DOV 21947; DULOXETINE; LITHIUM; MILNACIPRAN; MONOAMINE; NORADRENALIN; PALLADIUM; REBOXETINE; RHODIUM; SEROTONIN NORADRENALIN REUPTAKE INHIBITOR; TRIFLUOROMETHANESULFONIC ACID;

ARTICLE; CATALYSIS; CYCLIZATION; DRUG EFFICACY; DRUG OXIDATION; DRUG SYNTHESIS; ENANTIOMER; GRIGNARD REACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROGENATION; IC 50; LIPOPHILICITY; METHYLATION; NONHUMAN; PAIN; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; CACO-2 CELLS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MEMBRANE TRANSPORT PROTEINS; MODELS, CHEMICAL; NEUROTRANSMITTER AGENTS; NEUROTRANSMITTER TRANSPORT PROTEINS; NOREPINEPHRINE; PAIN; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

RODENTIA;

EID: 44749087708     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.05.077     Document Type: Article

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