Disruption of sarcolemmal atp-sensitive potassium channel activity impairs the cardiac response to systolic overload

Circulation Research

Volumn 103, Issue 9, 2008, Pages 1009-1017

  Hu, Xinli ^a   Xu, Xin ^a   Huang, Yimin ^b   Fassett, John ^a   Flagg, Thomas P ^c   Zhang, Ying ^b   Nichols, Colin G ^c   Bache, Robert J ^a   Chen, Yingjie ^a,d  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

Author keywords

ATP sensitive potassium channels; Cardiac hypertrophy; PGC 1

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; SULFONYLUREA RECEPTOR 1; TRANSCRIPTION FACTOR FKHR; ABC TRANSPORTER; DRUG RECEPTOR; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, MOUSE; INWARDLY RECTIFYING POTASSIUM CHANNEL; MESSENGER RNA; POTASSIUM CHANNEL BLOCKING AGENT; PPARGC1A PROTEIN, MOUSE; SMALL INTERFERING RNA; SULFONYLUREA RECEPTOR; TRANSACTIVATOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE OVERLOAD; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; SYSTOLIC BLOOD PRESSURE; ANIMAL; AORTA; C57BL MOUSE; CELL CULTURE; CELL HYPOXIA; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; ENERGY METABOLISM; GENETIC TRANSFECTION; GENETICS; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE; HEMODYNAMICS; HOSPITALIZATION; LIGATION; METABOLISM; MOLECULAR GENETICS; MOUSE MUTANT; MUTATION; NEWBORN; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PROMOTER REGION; RAT; RNA INTERFERENCE; SARCOLEMMA; TRANSGENIC MOUSE;

ANIMALS; ANIMALS, NEWBORN; AORTA; ATP-BINDING CASSETTE TRANSPORTERS; BASE SEQUENCE; CELL HYPOXIA; CELLS, CULTURED; CONSTRICTION; DISEASE MODELS, ANIMAL; ENERGY METABOLISM; FORKHEAD TRANSCRIPTION FACTORS; HEMODYNAMICS; HYPERTROPHY, LEFT VENTRICULAR; KATP CHANNELS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MUTATION; MYOCARDIUM; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROMOTER REGIONS (GENETICS); RATS; RECEPTORS, DRUG; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; SARCOLEMMA; SEVERITY OF ILLNESS INDEX; TRANS-ACTIVATORS; TRANSFECTION; VENTRICULAR DYSFUNCTION, LEFT;

EID: 55449134162     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.107.170795     Document Type: Article

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