Clinical outcomes of diabetic foot management with circulat

Phytotherapy Research

Volumn 22, Issue 10, 2008, Pages 1292-1298

  Olalde, J A ^a   Magarici, M ^a   Amendola, F ^a   Del Castillo, O ^a   Gonzalez, S ^a   Muhammad, A ^a  

^a Adaptogenic Medical Center   (Venezuela)

Author keywords

Adaptogens; Diabetes; Diabetic foot amputation; Systemic

Indexed keywords

CIRCULAT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROLLED STUDY; DIABETIC FOOT; DISEASE CLASSIFICATION; DISEASE SEVERITY; DRUG FORMULATION; FEMALE; FOOT AMPUTATION; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; TREATMENT OUTCOME; ULCER HEALING;

COHORT STUDIES; DIABETES MELLITUS, TYPE 2; DIABETIC FOOT; HUMANS; MIDDLE AGED; PLANT EXTRACTS; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 55449126476     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2482     Document Type: Article

References (103)

1. Abbott CA, Carrington AL, Ashe H et al. 2002. The North-West Diabetes Foot Care Study: incidence of, and risk factors for, new diabetic foot ulceration in a community-based patient cohort. Diabet Med 19: 377-384.
2. Abidov M, Crendal F, Grachev S et al. 2003. Effect of extracts from Rhodiola rosea and Rhodiola crenulata (Crassulaceae) roots on ATP content in mitochondria of skeletal muscles. Bull Exp Biol Med 136: 585-587.
3. Antoshechkin A, Olalde J, Magarici M et al. 2007. Analysis of effects of the herbal preparation Circulat on gene expression levels in cultured human fibroblasts. Phytother Res 21: 777-789.
4. Apelqvist J, Larsson J. 2000. What is the most effective way to reduce incidence of amputation in the diabetic foot? Diabetes Metab Res Rev 16(Suppl 1): S75-S83.
5. Apelqvist J, Larsson J, Agardh CD. 1993. Long-term prognosis for diabetic patients with foot ulcers. J Intern Med 233: 485-491.
6. Armstrong DG, Lavery LA, Quebedeaux TL, Walker SC. 1997. Surgical morbidity and the risk of amputation due to infected puncture wounds in diabetic versus nondiabetic adults. South Med J 90: 384-389.
7. Azizov AP. 1997. [Effects of eleutherococcus, elton, leuzea, and leveton on the blood coagulation system during training in athletes.] Eksp Klin Farmakol 60: 58-60.
8. Bae JW, Lee MH. 2004. Effect and putative mechanism of action of ginseng on the formation of glycated hemoglobin in vitro. J Ethnopharmacol 91: 137-140.
9. Bell DR, Gochenaur K. 2006. Direct vasoactive and vasoprotective properties of anthocyanin-rich extracts. J Appl Physiol 100: 1164-1170.
10. Benotmane A, Mohammedi F, Ayad F. 2000. Diabetic foot lesions: etiologic and prognostic factors. Diabetes Metab 26: 113-117.
11. Bilenko V, Bilenko N, Harman-Boehm I et al. 2006. [Trends and characteristics of diabetes-related lower limb amputations in the Negev, 1996-1999.] Harefuah 145: 709-712, 784.
12. 2+ influx and release. Vasc Pharmacol 45: 171-176.
13. Ccahuana-Vasquez RA, Santos SS, Koga-Ito CY, Jorge AO. 2007. Antimicrobial activity of Uncaria tomentosa against oral human pathogens. Pesqui Odontol Bras 21: 46-50.
14. Cesarone MR, Incandela L, De Sanctis MT et al. 2001. Evaluation of treatment of diabetic microangiopathy with total triterpenic fraction of Centella asiatica: a clinical prospective randomized trial with a microcirculatory model. Angiology 52(Suppl 2): S49-S54.
15. Chadwick WA, Roux S, van de Venter M et al. 2007 Anti-diabetic effects of Sutherlandia frutescens in Wistar rats fed a diabetogenic diet. J Ethnopharmacol 109: 121-127.
16. Chen ZP, Cai Y, Phillipson JD. 1994. Studies on the anti-tumour, anti-bacterial, and wound-healing properties of dragon's blood. Planta Med 60: 541-545.
17. Cheng Z, Pang T, Gu M et al. 2006. Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK. Biochim Biophys Acta 1760: 1682-1689.
18. Dalby-Brown L, Barsett H, Landbo AK et al. 2005. Synergistic antioxidative effects of alkamides, caffeic acid derivatives, and polysaccharide fractions from Echinacea purpurea on in vitro oxidation of human low-density lipoproteins. Agric Food Chem 53: 9413-9423.
19. Faglia E, Favales F, Aldeghi A et al. 1998. Change in major amputation rate in a center dedicated to diabetic foot care during the 1980s: prognostic determinants for major amputation. J Diabetes Compl 12: 96-102.
20. Farnsworth NR, Kinghorn AD, Sorjarto DD et al. 1985. Siberian ginseng (Eleutherococcus senticosus): current status as an adaptogen. In Economic and Medicinal Plant Research, Vol. 1, Wagner H, Hikino H, Farnsworth NR (eds). Academic Press: London, 217-284.
21. Feng CG, Zhang LX, Liu X. 2005. [Progress in research of aldose reductase inhibitors in traditional medicinal herbs.] Zhongguo Zhong Yao Za Zhi 30: 1496-1500.
22. Fernando DJ. 1996. The prevalence of neuropathic foot ulceration in Sri Lankan diabetic patients. Ceylon Med J 41: 96-98.
23. Freier DO, Wright K, Klein K et al. 2003. Enhancement of the humoral immune response by Echinacea purpurea in female Swiss mice. Immunopharmacol Immunotoxicol 25: 551-560.
24. Gilani AH, Rahman AU. 2005. Trends in ethnopharmocology. J Ethnopharmacol 100: 43-49.
25. Gilbert B, Alves LF. 2003. Synergy in plant medicines. Curr Med Chem 10: 13-20.
26. Greenspan HC, Aruoma OI, Arouma O. 1994. Could oxidative stress initiate programmed cell death in HIV infection? A role for plant derived metabolites having synergistic antioxidant activity. Chem Biol Interact 91: 187-197.
27. Groom SN, Johns T, Oldfield PR. 2007. The potency of immunomodulatory herbs may be primarily dependent upon macrophage activation. J Med Food 10: 73-79.
28. Gulam-Abbas Z, Lutale JK, Morbach S et al. 2002. Clinical outcome of diabetes patients hospitalized with foot ulcers, Dar el Salaam, Tanzania. Diabet Med 19: 575-579.
29. Han SB, Yoon YD, Ahn HJ et al. 2003. Toll-like receptor-mediated activation of B cells and macrophages by polysaccharide isolated from cell culture of Acanthopanax senticosus. Int Immunopharmacol 3: 1301-1312.
30. Hong L, Xun M, Wutong W. 2007. Anti-diabetic effect of an alpha-glucan from fruit body of maitake (Grifola frondosa) on KK-Ay mice. J Pharm Pharmacol 59: 575-582.
31. Jung KH, Ha E, Kim MJ et al. 2006. Ganoderma lucidum extract stimulates glucose uptake in L6 rat skeletal muscle cells. Acta Biochim Pol 53: 597-601.
32. Jurkstiene V, Kondrotas AJ, Kevelaitis E. 2004. [Compensatory reactions of immune system and action of Purple Cone-flower (Echinacea purpurea (L.) Moench) preparations.] Medicina (Kaunas) 40: 657-662.
33. Kang DG, Sohn EJ, Kwon EK et al. 2002. Effects of berberine on angiotensin-converting enzyme and NO/cGMP system in vessels. Vasc Pharmacol 39: 281-286.
34. Katerere DR, Eloff JN. 2005. Antibacterial and antioxidant activity of Sutherlandia frutescens (Fabaceae), a reputed anti-HIV/AIDS phytomedicine. Phytother Res 19: 779-781.
35. Kim LS, Waters RF, Burkholder PM. 2002. Immunological activity of larch arabinogalactan and Echinacea: a preliminary, randomized, double-blind, placebo-controlled trial. Altern Med Rev 7: 138-149.
36. Kim MJ, Yoo KH, Kim JH et al. 2007. Effect of pinitol on glucose metabolism and adipocytokines in uncontrolled type 2 diabetes. Diabetes Res Clin Pract 77(Suppl 1): S247-S251.
37. Kim ND, Kim EM, Kang KW et al. 2003. Ginsenoside Rg3 inhibits phenylephrine-induced vascular contraction through induction of nitric oxide synthase. Br J Pharmacol 140: 661-670.
38. Kim S, Kubec R, Musah RA. 2006. Antibacterial and antifungal activity of sulfur-containing compounds from Petiveria alliacea L. J Ethnopharmacol 104: 188-192.
39. Kim SH, Kang KW, Kim KW, Kim ND. 2000. Procyanidins in crataegus extract evoke endothelium-dependent vasorelaxation in rat aorta. Life Sci 67: 121-131.
40. Ko WH, Yao XQ, Lau CW et al. 2000. Vasorelaxant and antiproliferative effects of berberine. Eur J Pharmacol 399: 187-196.
41. Kodama N, Murata Y, Nanba H. 2004. Administration of a polysaccharide from Grifola frondosa stimulates immune function of normal mice. J Med Food 7: 141-145.
42. Koltermann A, Hartkorn A, Koch E. 2007. Ginkgo biloba extract EGb((R)) 761 increases endothelial nitric oxide production in vitro and in vivo. Cell Mol Life Sci 64: 1715-1722.
43. Kundu JK, Mossanda KS, Na HK, Surh YJ. 2005. Inhibitory effects of the extracts of Sutherlandia frutescens (L.) R. Br. and Harpagophytum procumbens DC. on phorbol ester-induced COX-2 expression in mouse skin: AP-1 and CREB as potential upstream targets. Cancer Lett 218: 21-31.
44. Kuo CL, Chi CW, Liu TY. 2004. The anti-inflammatory potential of berberine in vitro and in vivo. Cancer Lett 203: 127-137.
45. Kwan CY, Zhang WB, Sim SM et al. 2004. Vascular effects of Siberian ginseng (Eleutherococcus senticosus): endothelium-dependent NO- and EDHF-mediated relaxation depending on vessel size. Naunyn Schmiedebergs Arch Pharmacol 369: 473-480.
46. Kwon YI, Jang HD, Shetty K. 2006. Evaluation of Rhodiola crenulata and Rhodiola rosea for management of type II diabetes and hypertension. Asia Pac J Clin Nutr 15: 425-432.
47. Lacaille-Dubois, Franck U, Wagner H. 2001. Search for potential angiotensin converting enzyme (ACE)-inhibitors from plants. Phytomedicine 8: 47-52.
48. Lavery LA, Armstrong DG, Harkless LB. 1997. Classification of diabetic foot wounds. Ostomy Wound Manage 43: 44-48, 50, 52-53.
49. Lavery LA, Armstrong DG, Wunderlich RP. 2003. Diabetic Foot Syndrome: Evaluating the prevalance and incidence of foot pathology in Mexican Americans and non-Hispanic whites from a diabetes disease management cohort. Diabetes Care 26: 1435-1438.
50. Lehto S, Ronnemaa T, Pyorala K et al. 1996. Risk factors predicting lower extremity amputations in patients with NIDDM. Diabetes Care 19: 607-612.
51. Lee SY, Rhee HM. 1990. Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. Chem Pharm Bull (Tokyo) 38: 1359-1364.
52. Lishmanov IuB, Naumova AV, Afanas'ev SA et al. 1997. [Contribution of the opioid system to realization of inotropic effects of Rhodiola rosea extracts in ischemic and reperfusion heart damage in vitro.] Eksp Klin Farmakol 60: 34-36.
53. Liu JC, Chan P, Chen YJ et al. 1999. The antihypertensive effect of the berberine derivative 6-protoberberine in spontaneously hypertensive rats. Pharmacology 59: 283-289.
54. Liu TP, Lee CS, Liou SS et al. 2005. Improvement of insulin resistance by Acanthopanax senticosus root in fructose-rich chow-fed rats. Clin Exp Pharmacol Physiol 32: 649-654.
55. Lores RI, Cires Pujol M. 1990. Petiveria alleaceae L. (anamu). Study of the hypoglycemic effect. Med Interne 28: 347-352.
56. Lu L, Ying K, Wei S et al. 2004. Asiaticoside induction for cell-cycle progression, proliferation and collagen synthesis in human dermal fibroblasts. Int J Dermatol 43: 801-807.
57. Malay DS, Margolis DJ, Hoffstad OJ et al. 2006. The incidence and risks of failure to heal after lower extremity amputation for the treatment of diabetic neuropathic foot ulcer. J Foot Ankle Surg 45: 366-374.
58. Marrero S, Martínez A, González S et al. 2006. [Correlation between diabetic foot degree and type of amputation in a Public Medical Assistance Center.] Informe Méd 8: 169-177.
59. Miyajima S, Shirai A, Yamamoto S et al. 2006. Risk factors for major limb amputations in diabetic foot gangrene patients. Diabetes Res Clin Pract 71: 272-279.
60. Moon DO, Choi YH, Kim ND et al. 2007. Anti-inflammatory effects of beta-lapachone in lipopolysaccharide-stimulated BV2 microglia. Int Immunopharmacol 7: 506-514.
61. Morigiwa A, Kitabatake K, Fujimoto Y et al. 1986. Angiotensin converting enzyme-inhibitory triterpenes from Ganoderma lucidum. Chem Pharm Bull (Tokyo) 34: 3025-3028.
62. Moss SE, Klein R, Klein B. 1996. Long-term incidence of lower-extremity amputations in a diabetic population. Arch Fam Med 5: 391-398.
63. Nabuurs-Franssen MH, Huijberts MS, Nieuwenhuijzen Kruseman AC, Willems J, Schaper NC. 2005. Health-related quality of life of diabetic foot ulcer patients and their caregivers. Diabetologia 48: 1906-1910.
64. Nishida S, Satoh H. 2003. Mechanisms for the vasodilations induced by Ginkgo biloba extract and its main constituent, bilobalide, in rat aorta. Life Sci 72: 2659-2667.
65. Nyamu PN, Otieno CF, Amayo EO, McLigeyo SO. 2003. Risk factors and prevalence of diabetic foot ulcers at Kenyatta National Hospital, Nairobi. East Afr Med J 80: 36-43.
66. Olalde Rangel JA. 2005a. The systemic theory of living systems and relevance to CAM: Part I: the theory. Evid Based Complement Alternat Med 2: 13-18.
67. Olalde Rangel JA. 2005b. The systemic theory of living systems and relevance to CAM: the theory (Part II). Evid Based Complement Alternat Med 2: 129-137.
68. Olalde Rangel JA. 2005c. The systemic theory of living systems and relevance to CAM: the theory (Part III). Evid Based Complement Alternat Med 2: 267-275.
69. Olalde Rangel JA, Magarici M, Amendola F, del Castillo O. 2005. The systemic theory of living systems. Part IV: systemic medicine - the praxis. Evid Based Complement Alternat Med 2: 429-439.
70. Olmez E, Ilhan M. 1992 Evaluation of the alpha-adrenoceptor antagonistic action of berberine in isolated organs. Arzneimittelforschung 42: 1095-1097.
71. Park EK, Choo MK, Han MJ, Kim DH. 2004. Ginsenoside Rh1 possesses antiallergic and anti-inflammatory activities. Int Arch Allergy Immunol 133: 113-120.
72. Park SH, Lee SG, Kang SK, Chung SH. 2006. Acanthopanax senticosus reverses fatty liver disease and hyperglycemia in ob/ob mice. Arch Pharm Res 29: 768-776.
73. Pereira EM, Machado T de B, Leal IC et al. 2006. Tabebuia avellanedae naphthoquinones: activity against methicillin-resistant staphylococcal strains, cytotoxic activity and in vivo dermal irritability analysis. Ann Clin Microbiol Antimicrob 5: 5.
74. Pinello KC, Fonseca Ede S, Akisue G et al. 2006. Effects of Pfaffia paniculata (Brazilian ginseng) extract on macrophage activity. Life Sci 78: 1287-1292.
75. Piscoya J, Rodriguez Z, Bustamante SA et al. 2001. Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis. Inflamm Res 50: 442-448.
76. Plotnikov MB, Aliev OI, Vasil'ev AS et al. 2001. [Effect of Rhaponticum carthamoides extract on hemorheological properties of blood in rats with arterial hypertension.] Eksp Klin Farmakol 64: 45-47.
77. Raso GM, Pacilio M, Di Carlo G et al. 2002. In-vivo and in-vitro anti-inflammatory effect of Echinacea purpurea and Hypericum perforatum. J Pharm Pharmacol 54: 1379-1383.
78. Ratzmann KP, Drzimalla E, Raskovic M. 1994. [The 'diabetic foot' syndrome. Association with other complications and the incidence of amputation.] Med Klin (Munich) 89: 469-472.
79. Rayman G, Krishnan ST, Baker NR. 2004. Are we underestimating diabetes-related lower-extremity amputation rates? Results and benefits of the first prospective study. Diabetes Care 27: 1892-1896.
80. Reay JL, Kennedy DO, Scholey AB. 2005. Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity. J Psychopharmacol 19: 357-365.
81. Redman DA. 2000. Ruscus aculeatus (butcher's broom) as a potential treatment for orthostatic hypotension, with a case report. J Altern Complement Med 6: 539-549.
82. Rhyu MR, Kim JH, Kim EY. 2005. Radix angelica elicits both nitric oxide-dependent and calcium influx-mediated relaxation in rat aorta. J Cardiovasc Pharmacol 46: 99-104.
83. Sasagawa M, Cech NB, Gray DE et al. 2006. Echinacea alkylamides inhibit interleukin-2 production by Jurkat T cells. Int Immunopharmacol 6: 1214-1221.
84. Scazzocchio F, Cometa MF, Tomassini L, Palmery M. 2001. Antibacterial activity of Hydrastis canadensis extract and its major isolated alkaloids. Planta Med 67: 561-594.
85. Smolina TP, Solov'eva TF, Besednova NN. 2001. [Immunotropic activity of panaxans - bioglycans isolated from ginseng.] Antibiot Khimioter 46: 19-22.
86. Stermitz FR, Lorenz P, Tawara JN, Zenewicz LA, Lewis K. 2000. Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5′-methoxyhydnocarpin, a multidrug pump inhibitor. Proc Natl Acad Sci USA 97: 1433-1427.
87. Talpur NA, Echard BW, Fan AY et al. 2002. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol Cell Biochem 237: 129-136.
88. Tashmukhamedova MA, Almatov KT, Syrov VN. 1986. Comparative study of the effect of ecdysterone, turkesterone and nerobol on the function of rat liver mitochondria in experimental diabetes. Vopr Med Khim 32: 24-28.
89. Thyagarajan A, Zhu J, Sliva D. 2007. Combined effect of green tea and Ganoderma lucidum on invasive behavior of breast cancer cells. Int J Oncol 30: 963-969.
90. Trautner C, Haastert B, Spraul M et al. 2001. Unchanged incidence of lower-limb amputations in a German City, 1990-1998. Diabetes Care 24: 855-859.
91. Vaisberg AJ, Milla M, Planas MC et al. 1989. Taspine is the cicatrizant principle in Sangre de Grado extracted from Croton lechleri. Planta Med 55: 140-143.
92. Vibes J, Lasserre B, Gleye J, Declume C. 1994. Inhibition of thromboxane A2 biosynthesis in vitro by the main components of Crataegus oxyacantha (Hawthorn) flower heads. Prostaglandins Leukot Essent Fatty Acids 50: 173-175.
93. Volaco A, Chantelau E, Richter B. 2004. Outcome of critical foot ischaemia in longstanding diabetic patients: a retrospective cohort study in a specialised tertiary care centre. Vasa 33: 36-41.
94. Vuksan V, Sievenpiper JL, Koo VY et al. 2000. American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus. Arch Intern Med 160: 1009-1013.
95. Wang BX, Zhou QL, Yang M et al. 2003. Hypoglycemic mechanism of ginseng glycopeptide. Acta Pharmacol Sin 24: 61-66.
96. Wang SR, Guo ZQ, Liao JZ. 1993. [Experimental study on effects of 18 kinds of Chinese herbal medicine for synthesis of thromboxane A2 and PGI2]. Zhongguo Zhong Xi Yi Jie He Za Zhi 13: 167-170, 134.
97. Winell K, Niemi M, Lepantalo M. 2006. The national hospital discharge register data on lower limb amputations. Eur J Vasc Endovasc Surg 32: 66-70.
98. World Health Organization. 2006. WHO Fact Sheet No 312. WHO: Geneva.
99. Yang T, Jia M, Meng J et al. 2006. Immunomodulatory activity of polysaccharide isolated from Angelica sinensis. Int J Biol Macromol 39: 179-184.
100. Zhang HN, Lin ZB. 2004. Hypoglycemic effect of Ganoderma lucidum polysaccharides. Acta Pharmacol Sin 25: 191-195.
101. Zhang Y, Mills GL, Nair G. 2002. Cyclooxygenase inhibitory and antioxidant compounds from the mycelia of the edible mushroom Grifola frondosa. J Agric Food Chem 50: 7581-7585.
102. Zhou L, Yang Y, Wang X et al. 2007. Berberine stimulates glucose transport through a mechanism distinct from insulin. Metabolism 56: 405-412.
103. Zhu XL, Chen AF, Lin ZB. 2007. Ganoderma lucidum polysaccharides enhance the function of immunological effector cells in immunosuppressed mice. J Ethnopharmacol 111: 219-226.