Tabebuia avellanedae naphtoquinones: Activity against methicillin-resistant staphylococcal strains, cytotoxic activity and in vivo dermal irritability analysis

Annals of Clinical Microbiology and Antimicrobials

Volumn 5, Issue , 2006, Pages

  Pereira, Eliezer Menezes ^a   de Barros Machado, Thelma ^b   Ramos Leal, Ivana Correa ^a   Jesus, Desyreé Murta ^a   de Almeida Damaso, Clarissa Rosa ^a   Pinto, Antonio Ventura ^a   Giambiagi deMarval, Marcia ^a   Kuster, Ricardo Machado ^a   Netto dos Santos, Kátia Regina ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY BETA N LAPACHONE; ALPHA LAPACHONE; ANTIINFECTIVE AGENT; BETA LAPACHONE; LAPACHOL; METICILLIN; NAPHTHOQUINONE; UNCLASSIFIED DRUG; VANCOMYCIN; IRRITANT AGENT; PLANT EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; BACTERIUM ISOLATE; CELL CULTURE; CERCOPITHECIDAE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG STRUCTURE; EUKARYOTIC CELL; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CELL; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTEIN ANALYSIS; RABBIT; STAPHYLOCOCCUS; STAPHYLOCOCCUS EPIDERMIDIS; STAPHYLOCOCCUS HAEMOLYTICUS; TABEBUIA; TOXICITY TESTING; ANIMAL; CELL LINE; CERCOPITHECUS; CHEMISTRY; DRUG EFFECT; ISOLATION AND PURIFICATION; PATHOLOGY; PENICILLIN RESISTANCE; SKIN; STAPHYLOCOCCUS AUREUS;

ANIMALS; CELL LINE; CERCOPITHECUS AETHIOPS; IRRITANTS; METHICILLIN RESISTANCE; NAPHTHOQUINONES; PLANT EXTRACTS; RABBITS; SKIN; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STAPHYLOCOCCUS HAEMOLYTICUS; TABEBUIA;

EID: 33645772004     PISSN: 14760711     EISSN: 14760711     Source Type: Journal    
DOI: 10.1186/1476-0711-5-5     Document Type: Article

References (27)

1. de Santana CF, De Lima O, D'albuquerque IL, Lacerda AL, Martins DG: Antitumorall and toxicological properties of extracts of bark and various wood components of Pau d'arco (Tabebuia avellanedae). Rev Inst Antibiot 1968, 8:89-94.
2. Ueda S, Umemura T, Dohguchi K, Matsuzald T, Tokuda H, Nishino H, Iwashima A: Production of anti-tumour-promoting furanonaphthoquinones in Tabebuia avellanedae cell cultures. Phytochemistry 1994, 36:323-325.
3. Machado TB, Pinto AV, Pinto MCFR, Leal ICR, Silva MG, Amaral ACF, Kuster RM, Santos KRN: In vitro activity of Brazilian medicinal plants, naturally occuring naphthoquinones and their analogues, against methicillin-resistant Staphylococcus aureus. Int J Antim Agents 2003:279-284.
4. Pinto CN, Dantas AP, De Moura KC, Emery FS, Polequevitch PF, Pinto MC, De Castro SL, Pinto AV: Chemical reactivity studies with naphthoquinones from Tabebuia with anti-trypanosomal efficacy. Arzneimittelforschung 2000, 50(12):1120-8.
5. Riffel A, Medina LF, Stefani V, Santos RC, Bizani D, Brandelli A: In vitro antimicrobial activity of a new series of 1,4-naphthoquinones. Braz J Med Biol Res 2002, 35(7):811-8.
6. Miranda FGG, Vilar JC, Alves IAN, Cavalcanti SCH, Antoniolli AR: Antinociceptive and antiedematogenic properties and acute toxicity of Tabebuia ovellanedae Lor. ex Griseb. inner bark aqueous extract. BMC Pharmacol 2001, 1:6.
7. Nunes APF, Teixeira LM, Bastos CCR, Silva MG, Ferreira RB, Fonseca LS, Santos KRN: Genomic characterization of oxacillin-resistant Staphylococcus epidermidis and Staphylococcus haermolyticus isolated from Brazilian medical centers. J Hosp Infect 2005, 59(1):19-26.
8. Diekema DJ, Pfaller MA, Schmitz FJ, Smayevsky J, Bell J, Jones RN, Beach M, SENTRY Participants Group: Survey of infections due to Staphylococcus species: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, Latin America, Europe, and the Western Pacific region for the SENTRY Antimicrobial Surveillance Program, 1997-1999. Clin Infect Dis 2001, 32(S12):S 114-32.
9. Karchmer AW: Nosocomial bloodstream infections: organisms, risk factors, and implications. Clin Inf Dis 2000,31(Suppl 4): S139-S143.
10. Romero-Vivas J, Rubio M, Fernandez C, Picazo JJ: Mortality associated with nosocomial bacteremia due to methicillin resistance Staphylococcus aureus. Clin Infect Dis 1995, 21:1417-1423.
11. Nunes APF, Teixeira LM, Bastos CCR, Fonseca LS, Santos KRN: Susceptibility of Brazilian staphylococcall strains to glycopeptides evaluated by different testing methods. Curr Microbial 2002, 44:385-390.
12. Hiramatsu K. Vancomycin-resistant Staphylococcus aureus: a new model of antibiotic resistance. Lancet Infect Dis 2001, 1(3):147-55.
13. Shin DY, Kim SN, Chae JH, Hyun SS, Seo SY, Lee YS, Lee KO, Kim SH, Lee YS, Jeong JM, Choi NS, Suh YG: Syntheses and anti-MRSA activities of the C3 analogs of mansonone F, a potent antibacterial sesquiterpenoid: insights into its structural requirements for anti-MRSA activity. Bioorg Med Chem Lett 2004, 14(17):4519-23.
14. Cruz FS, Docampo R, De Souza W: Effect of beta-lapachone on hydrogen peroxide production in Trypanosoma cruzi. Acta Trap 1978, 3S(1):35-40.
15. Miguel Del Corral JM, Castro MA, Gordaliza M, Martin ML, Gualberto SA, Gamito AM, Cuevas C, San Feliciano A: Synthesis and cytotoxicity of new aminoterpenylquinones. Bioorg Med Chem 2005, 13(3):631-44.
16. National Committee for Clinical Laboratory Standards: Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically;Approved Standard - Eighth edition. NCCLS document M7-A6. NCCLS, Wayne, Pennsylvania, USA 2003.
17. Thompson KD: Antiviral activity of viracea against acyclovir susceptible and acyclovir resistant strains of herpes simplex virus. Antiviral Res 1998,39:55-61.
18. Paternó E: Richerce sull acido lapachico. Gazz Chem Ital 1882, 12:337-92.
19. Hooker SC: The constitution of lapachic acid (lapachol) and its derivatives. J Chem Soc 1892, 6:611-51.
20. Pinto AV, Pinto MCFR, Oliveira CGT: Sintese de α e β-nor-lapachonas. Propriedades em meio ácido e reações com N- bromosuccinamida. Ann Acad Bras Ci 1992, 54:107-14.
21. Isenberg HD: Clinical Microbiology Procedures Handbook Vol 1. ASM Washington, DC 1992. Sec. 5.16
22. 6 compounds prevent the death of yeast cells due to menadione, a reactive oxygen generator. Biochim Bioph Acta (BBA) 2005, 1722:84-91.
23. Laport MS, De Castro AC, Villardo A, Lemos JA, Bastos MC, Giambiagi-de-Marval M: Expression of the major heat shock proteins DnaK and GroEL in Streptococcus pyogenes: a comparison to Enterococcus faecalis and Staphylococcus aureus. Curr Microbiol 2000, 42(4):264-8.
24. Draize JH, Woodward G, Calvery HO: Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes. J Pharmacol EKptl Therap 1944, 82:377.
25. de Witte NV, Stoppani AO, Dubin M: 2-Phenyl-beta-lapachone can affect mitochondrial function by redox cycling mediated oxidation. Arch Biochern Biophys 2004, 432(2):129-35.
26. Pouzaud F, Bernard-Beaubois K, Thevenin M, Warnet JM, Hayern G, Rat P: In vitro discrimination of fluoroquinolones toxicity on tendon cells: involvement of oxidative stress. J Pharmacol Exp Ther 2004, 308(1):394-402.
27. Xu RH, Pelicano H, Zhou Y, Carew JS, Feng L, Bhalla KN, Keating Mj, Huang P: Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia. Cancer Res 2005, 65(2):613-21.