Human dendritic cells infected with an adenoviral vector suppress proliferation of autologous and allogeneic T cells

Immunology

Volumn 125, Issue 4, 2008, Pages 469-479

  Newton, Katy R ^a   Sala Soriano, Emma ^a   Varsani, Hemlata ^a   Stephenson, John R ^b   Goldblatt, David ^a   Wedderburn, Lucy R ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

Anergy suppression tolerance; Dendritic cells; Gene therapy

Indexed keywords

ADENOVIRUS VECTOR; B7 ANTIGEN; CD40 ANTIGEN; CD83 ANTIGEN; CD86 ANTIGEN; CELL SURFACE MARKER; CYTOKINE; GAMMA INTERFERON; HLA DR ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; PHYTOHEMAGGLUTININ; PROSTAGLANDIN E2; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL VIABILITY; CLONAL ANERGY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; FLOW CYTOMETRY; GENE THERAPY; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE PROLIFERATION; MIXED LYMPHOCYTE REACTION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; VIRUS INFECTION;

ADENOVIRIDAE; ADENOVIRIDAE INFECTIONS; ANTIBODIES, BLOCKING; CELLS, CULTURED; CLONAL ANERGY; CULTURE MEDIA, CONDITIONED; CYTOKINES; DENDRITIC CELLS; FLOW CYTOMETRY; GENETIC VECTORS; HUMANS; IMMUNE TOLERANCE; IMMUNOSUPPRESSION; INTERLEUKIN-10; LYMPHOCYTE CULTURE TEST, MIXED; T-LYMPHOCYTES; TRANSDUCTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 55449125843     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2008.02860.x     Document Type: Article

References (37)

1. Roy-Chowdhury J, Horwitz MS. Evolution of adenoviruses as gene therapy vectors. Mol Ther 2002 5 : 340 4.
2. Kanerva A, Hemminki A. Modified adenoviruses for cancer gene therapy. Int J Cancer 2004 110 : 475 80.
3. Raper SE, Wilson JM, Yudkoff M, Robinson MB, Ye X, Batshaw ML. Developing adenoviral-mediated in vivo gene therapy for ornithine transcarbamylase deficiency. J Inherit Metab Dis 1998 21 (Suppl 1 119 37.
4. Raper SE, Yudkoff M, Chirmule N et al. A pilot study of in vivo liver-directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiency. Hum Gene Ther 2002 13 : 163 75.
5. Kanerva A, Bauerschmitz GJ, Yamamoto M, Lam JT, Alvarez RD, Siegal GP, Curiel DT, Hemminki A. A cyclooxygenase-2 promoter-based conditionally replicating adenovirus with enhanced infectivity for treatment of ovarian adenocarcinoma. Gene Ther 2004 11 : 552 9.
6. Breidenbach M, Rein DT, Everts M et al. Mesothelin-mediated targeting of adenoviral vectors for ovarian cancer gene therapy. Gene Ther 2005 12 : 187 93.
7. Barouch DH, Nabel GJ. Adenovirus vector-based vaccines for human immunodeficiency virus type 1. Hum Gene Ther 2005 16 : 149 56.
8. Chen PW, Wang M, Bronte V, Zhai Y, Rosenberg SA, Restifo NP. Therapeutic antitumor response after immunization with a recombinant adenovirus encoding a model tumor-associated antigen. J Immunol 1996 156 : 224 31.
9. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998 392 : 245 52.
10. Philip R, Alters SE, Brunette E, Ashton J, Gadea J, Yau J, Lebkowski J, Philip M. Dendritic cells loaded with MART-1 peptide or infected with adenoviral construct are functionally equivalent in the induction of tumor-specific cytotoxic T lymphocyte responses in patients with melanoma. J Immunother 2000 23 : 168 76.
11. Wold WS, Doronin K, Toth K, Kuppuswamy M, Lichtenstein DL, Tollefson AE. Immune responses to adenoviruses: viral evasion mechanisms and their implications for the clinic. Curr Opin Immunol 1999 11 : 380 6.
12. Fooks AR, Schadeck E, Liebert UG, Dowsett AB, Rima BK, Steward M, Stephenson JR, Wilkinson GW. High-level expression of the measles virus nucleocapsid protein by using a replication-deficient adenovirus vector: induction of an MHC-1-restricted CTL response and protection in a murine model. Virology 1995 210 : 456 65.
13. Horwitz MS. Adenovirus immunoregulatory genes and their cellular targets. Virology 2001 279 : 1 8.
14. Horwitz MS. Function of adenovirus E3 proteins and their interactions with immunoregulatory cell proteins. J Gene Med 2004 6 (Suppl 1 S172 83.
15. Tuettenberg A, Jonuleit H, Tuting T, Bruck J, Biermann V, Kochanek S, Knop J, Enk AH. Early adenoviral gene expression mediates immunosuppression by transduced dendritic cell (DC): implications for immunotherapy using genetically modified DC. J Immunol 2004 172 : 1524 30.
16. Mahnke K, Schmitt E, Bonifaz L, Enk AH, Jonuleit H. Immature, but not inactive: the tolerogenic function of immature dendritic cells. Immunol Cell Biol 2002 80 : 477 83.
17. Mellor AL, Munn DH. IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol 2004 4 : 762 74.
18. Barrat FJ, Cua DJ, Boonstra A et al. In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J Exp Med 2002 195 : 603 16.
19. Pedersen AE, Gad M, Walter MR, Claesson MH. Induction of regulatory dendritic cells by dexamethasone and 1alpha,25-Dihydroxyvitamin D(3). Immunol Lett 2004 91 : 63 9.
20. Oh S, Eichelberger MC. Polarization of allogeneic T-cell responses by influenza virus-infected dendritic cells. J Virol 2000 74 : 7738 44.
21. Servet-Delprat C, Vidalain PO, Bausinger H et al. Measles virus induces abnormal differentiation of CD40 ligand-activated human dendritic cells. J Immunol 2000 164 : 1753 60.
22. Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 1994 179 : 1109 18.
23. Diss JK, Archer SN, Hirano J, Fraser SP, Djamgoz MB. Expression profiles of voltage-gated Na(+) channel alpha-subunit genes in rat and human prostate cancer cell lines. Prostate 2001 48 : 165 78.
24. Diss JK, Faulkes DJ, Walker MM, Patel A, Foster CS, Budhram-Mahadeo V, Djamgoz MB, Latchman DS. Brn-3a neuronal transcription factor functional expression in human prostate cancer. Prostate Cancer Prostatic Dis 2006 9 : 83 91.
25. Tan PH, Beutelspacher SC, Xue SA et al. Modulation of human dendritic-cell function following transduction with viral vectors: implications for gene therapy. Blood 2005 105 : 3824 32.
26. Arthur JF, Butterfield LH, Roth MD et al. A comparison of gene transfer methods in human dendritic cells. Cancer Gene Ther 1997 4 : 17 25.
27. Rea D, Schagen FH, Hoeben RC, Mehtali M, Havenga MJ, Toes RE, Melief CJ, Offringa R. Adenoviruses activate human dendritic cells without polarization toward a T-helper type 1-inducing subset. J Virol 1999 73 : 10245 53.
28. Schumacher L, Ribas A, Dissette VB, McBride WH, Mukherji B, Economou JS, Butterfield LH. Human dendritic cell maturation by adenovirus transduction enhances tumor antigen-specific T-cell responses. J Immunother 2004 27 : 191 200.
29. Takahashi T, Kuniyasu Y, Toda M, Sakaguchi N, Itoh M, Iwata M, Shimizu J, Sakaguchi S. Immunologic self-tolerance maintained by CD25 + CD4 + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol 1998 10 : 1969 80.
30. Jonuleit H, Tuting T, Steitz J, Bruck J, Giesecke A, Steinbrink K, Knop J, Enk AH. Efficient transduction of mature CD83 + dendritic cells using recombinant adenovirus suppressed T cell stimulatory capacity. Gene Ther 2000 7 : 249 54.
31. Zhong L, Granelli-Piperno A, Choi Y, Steinman RM. Recombinant adenovirus is an efficient and non-perturbing genetic vector for human dendritic cells. Eur J Immunol 1999 29 : 964 72.
32. Rea D, Laface D, Hutchins B, Kwappenberg K, Melief CJ, Hoeben RC, Offringa R. Recombinant adenovirus-transduced human dendritic cells engineered to secrete interleukin-10 (IL-10) suppress Th1-type responses while selectively activating IL-10-producing CD4 + T cells. Hum Immunol 2004 65 : 1344 55.
33. Miller G, Lahrs S, Pillarisetty VG, Shah AB, DeMatteo RP. Adenovirus infection enhances dendritic cell immunostimulatory properties and induces natural killer and T-cell-mediated tumor protection. Cancer Res 2002 62 : 5260 6.
34. Morelli AE, Larregina AT, Ganster RW et al. Recombinant adenovirus induces maturation of dendritic cells via an NF-kappaB-dependent pathway. J Virol 2000 74 : 9617 28.
35. Philpott NJ, Nociari M, Elkon KB, Falck-Pedersen E. Adenovirus-induced maturation of dendritic cells through a PI3 kinase-mediated TNF-alpha induction pathway. Proc Natl Acad Sci U S A 2004 101 : 6200 5.
36. Bergelson JM, Cunningham JA, Droguett G et al. Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science 1997 275 : 1320 3.
37. Bartz H, Buning-Pfaue F, Turkel O, Schauer U. Respiratory syncytial virus induces prostaglandin E2, IL-10 and IL-11 generation in antigen presenting cells. Clin Exp Immunol 2002 129 : 438 45.