Neurochemical dementia diagnostics: Assays in CSF and blood

European Archives of Psychiatry and Clinical Neuroscience

Volumn 258, Issue SUPPL. 5, 2008, Pages 44-49

  Lewczuk, Piotr ^a   Hornegger, Joachim ^b   Zimmermann, Rüdiger ^a   Otto, Markus ^c   Wiltfang, Jens ^d   Kornhuber, Johannes ^a  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c UNIVERSITY OF ULM   (Germany)

^d UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Alzheimer's disease; Amyloid; Cerebrospinal fluid; Dementia; Tau

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; PHOSPHOPROTEIN; TAU PROTEIN;

ALZHEIMER DISEASE; BLOOD ANALYSIS; CEREBROSPINAL FLUID ANALYSIS; CONFERENCE PAPER; DEMENTIA; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST; DIFFERENTIAL DIAGNOSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN DETERMINATION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

AMYLOID BETA-PROTEIN; ANIMALS; DEMENTIA; HUMANS; NEUROCHEMISTRY; PHOSPHORYLATION; TAU PROTEINS;

EID: 55449124542     PISSN: 09401334     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00406-008-5005-3     Document Type: Conference Paper

References (59)

1. N Andreasen L Minthon A Clarberg P Davidsson J Gottfries E Vanmechelen H Vanderstichele B Winblad K Blennow 1999 Sensitivity, specificity, and stability of CSF-tau in AD in a community-based patient sample Neurology 53 1488 1494
2. N Andreasen L Minthon P Davidsson E Vanmechelen H Vanderstichele B Winblad K Blennow 2001 Evaluation of CSF-tau and CSF-Aβ42 as diagnostic markers for Alzheimer disease in clinical practice Arch Neurol 58 373 379
3. M Bibl B Mollenhauer H Esselmann P Lewczuk HW Klafki K Sparbier A Smirnov L Cepek C Trenkwalder E Ruther J Kornhuber M Otto J Wiltfang 2006 CSF amyloid-beta-peptides in Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease dementia Brain 129 1177 1187
4. M Bibl B Mollenhauer P Lewczuk H Esselmann S Wolf C Trenkwalder M Otto G Stiens E Ruther J Kornhuber J Wiltfang 2007 Validation of amyloid-beta peptides in CSF diagnosis of neurodegenerative dementias Mol Psychiatry 12 671 680
5. M Bibl B Mollenhauer S Wolf H Esselmann P Lewczuk J Kornhuber J Wiltfang 2007 Reduced CSF carboxyterminally truncated Abeta peptides in frontotemporal lobe degenerations J Neural Transm 114 621 628
6. K Blennow H Hampel 2003 CSF markers for incipient Alzheimer's disease Lancet Neurol 2 605 613
7. K Blennow E Vanmechelen H Hampel 2001 CSF total tau, Aβ42 and phosphorylated tau protein as biomarkers for Alzheimer's disease Mol Neurobiol 24 87 97
8. K Blennow A Wallin O Hager 1993 Low frequency of post-lumbar puncture headache in demented patients Acta Neurol Scand 88 221 223
9. M Citron TS Diehl G Gordon AL Biere P Seubert DJ Selkoe 1996 Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities Proc Natl Acad Sci USA 93 13170 13175
10. M Di Luca L Pastorino A Bianchetti J Perez LA Vignolo GL Lenzi M Trabucchi F Cattabeni A Padovani 1998 Differential level of platelet amyloid β precursor protein isoforms: an early marker for Alzheimer disease Arch Neurol 55 1195 1200
11. S Engelborghs K De Vreese T Van de Casteele H Vanderstichele B Van Everbroeck P Cras JJ Martin E Vanmechelen PP De Deyn 2008 Diagnostic performance of a CSF-biomarker panel in autopsy-confirmed dementia Neurobiol Aging 29 1143 1159
12. RA Fuentealba G Farias J Scheu M Bronfman MP Marzolo NC Inestrosa 2004 Signal transduction during amyloid-beta-peptide neurotoxicity: role in Alzheimer disease Brain Res Brain Res Rev 47 275 289
13. D Galasko L Chang R Motter CM Clark J Kaye D Knopman R Thomas D Kholodenko D Schenk I Lieberburg B Miller R Green R Basherad L Kertiles MA Boss P Seubert 1998 High cerebrospinal fluid tau and low amyloid β42 levels in the clinical diagnosis of Alzheimer disease and relation to apolipoprotein E genotype Arch Neurol 55 937 945
14. NR Graff-Radford JE Crook J Lucas BF Boeve DS Knopman RJ Ivnik GE Smith LH Younkin RC Petersen SG Younkin 2007 Association of low plasma abeta42/abeta40 ratios with increased imminent risk for mild cognitive impairment and Alzheimer disease Arch Neurol 64 354 362
15. I Grundke-Iqbal K Iqbal YC Tung M Quinlan HM Wisniewski LI Binder 1986 Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology Proc Natl Acad Sci USA 83 4913 4917
16. H Hampel K Buerger R Kohnken SJ Teipel R Zinkowski HJ Moeller SI Rapoport P Davies 2001 Tracking of Alzheimer's disease progression with cerebrospinal fluid tau protein phosphorylated at threonine 231 Ann Neurol 49 545 546
17. H Hampel K Buerger R Zinkowski SJ Teipel A Goernitz N Andreasen M Sjoegren J DeBernardis D Kerkman K Ishiguro H Ohno E Vanmechelen H Vanderstichele C McCulloch HJ Moller P Davies K Blennow 2004 Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: a comparative cerebrospinal fluid study Arch Gen Psychiatry 61 95 102
18. O Hansson H Zetterberg P Buchhave E Londos K Blennow L Minthon 2006 Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study Lancet Neurol 5 228 234
19. C Hesse L Rosengren N Andreasen P Davidsson H Vanderstichele E Vanmechelen K Blennow 2001 Transient increase in total tau but not phospho-tau in human cerebrospinal fluid after acute stroke Neurosci Lett 297 187 190
20. (1-42) and tau levels in CSF Neurology 52 1555 1562
21. N Ida T Hartmann J Pantel J Schröder R Zerfass H Förstl R Sandbrink CL Masters K Beyreuther 1996 Analysis of heterogeneous βA4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay J Biol Chem 271 22908 22914
22. K Iqbal I Grundke-Iqbal T Zaidi PA Merz GY Wen SS Shaikh HM Wisniewski I Alafuzoff B Winblad 1986 Defective brain microtubule assembly in Alzheimer's disease Lancet 2 421 426
23. J Kang HG Lemaire A Unterbeck JM Salbaum CL Masters KH Grzeschik G Multhaup K Beyreuther B Muller-Hill 1987 The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor Nature 325 733 736
24. H Klafki D Abramowski R Swoboda PA Paganetti M Staufenbiel 1996 The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities J Biol Chem 271 28655 28659
25. HW Klafki M Staufenbiel J Kornhuber J Wiltfang 2006 Therapeutic approaches to Alzheimer's disease Brain 129 2840 2855
26. YM Kuo TA Kokjohn MD Watson AS Woods RJ Cotter LI Sue WM Kalback MR Emmerling TG Beach AE Roher 2000 Elevated Aβ42 in skeletal muscle of Alzheimer disease patients suggests peripheral alterations of AβPP metabolism Am J Pathol 156 797 805
27. P Lewczuk G Beck H Esselmann R Bruckmoser R Zimmermann M Fiszer M Bibl JM Maler J Kornhuber J Wiltfang 2006 Effect of sample collection tubes on cerebrospinal fluid concentrations of Tau proteins and amyloid β peptides Clin Chem 52 332 334
28. P Lewczuk G Beck O Ganslandt H Esselmann F Deisenhammer A Regeniter HF Petereit H Tumani A Gerritzen P Oschmann J Schroder P Schonknecht K Zimmermann H Hampel K Burger M Otto S Haustein K Herzog R Dannenberg U Wurster M Bibl JM Maler U Reubach J Kornhuber J Wiltfang 2006 International quality control survey of neurochemical dementia diagnostics Neurosci Lett 409 1 4
29. P Lewczuk H Esselmann M Bibl G Beck JM Maler M Otto J Kornhuber J Wiltfang 2004 Tau protein phosphorylated at threonine 181 in CSF as a neurochemical biomarker in Alzheimer's disease: original data and review of the literature J Mol Neurosci 23 115 122
30. P Lewczuk H Esselmann M Bibl S Paul J Svitek J Miertschischk R Meyrer A Smirnov JM Maler C Klein M Otto S Bleich W Sperling J Kornhuber E Ruther J Wiltfang 2004 Electrophoretic separation of amyloid beta peptides in plasma Electrophoresis 25 3336 3343
31. P Lewczuk H Esselmann M Otto JM Maler AW Henkel MK Henkel O Eikenberg C Antz WR Krause U Reulbach J Kornhuber J Wiltfang 2004 Neurochemical diagnosis of Alzheimer's dementia by CSF Aβ42, Aβ42/Aβ40 ratio and total tau Neurobiol Aging 25 273 281
32. Lewczuk P, Kamrowski-Kruck H, Peters O, Heuser I, Jessen F, Popp J, Burger K, Hampel H, Frolich L, Wolf S, Prinz B, Jahn H, Luckhaus C, Perneczky R, Hull M, Schroder J, Kessler H, Pantel J, Gertz H-J, Klafki H-W, Kolsch H, Reulbach U, Esselmann H, Maler JM, Bibl M, Kornhuber J, Wiltfang J (2008) Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study. Mol Psychiatry (in press)
33. P Lewczuk J Kornhuber H Vanderstichele E Vanmechelen H Esselmann M Bibl S Wolf M Otto U Reulbach H Kolsch F Jessen J Schroder P Schonknecht H Hampel O Peters E Weimer R Perneczky H Jahn C Luckhaus U Lamla T Supprian JM Maler J Wiltfang 2008 Multiplexed quantification of dementia biomarkers in the CSF of patients with early dementias and MCI: a multicenter study Neurobiol Aging 29 812 818
34. P Lewczuk J Kornhuber J Wiltfang 2006 The german competence net dementias: standard operating procedures for the neurochemical dementia diagnostics J Neural Transm 113 1075 1080
35. P Lewczuk J Wiltfang 2008 Neurochemical dementia diagnostics: state of the art and research perspectives Proteomics 8 1292 1301
36. SF Lichtenthaler D Beher HS Grimm R Wang MS Shearman CL Masters K Beyreuther 2002 The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain Proc Natl Acad Sci USA 99 1365 1370
37. R Mayeux 1998 Evaluation and use of diagnostic tests in Alzheimer's disease Neurobiol Aging 19 139 143
38. R Mayeux LS Honig MX Tang J Manly Y Stern N Schupf PD Mehta 2003 Plasma Aβ40 and Aβ42 and Alzheimer's disease: relation to age, mortality, and risk Neurology 61 1185 1190
39. PD Mehta T Pirttila BA Patrick M Barshatzky SP Mehta 2001 Amyloid [beta] protein 1-40 and 1-42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease Neurosci Lett 304 102 106
40. A Mudher S Lovestone 2002 Alzheimer's disease-do tauists and baptists finally shake hands? Trends Neurosci 25 22 26
41. M Otto H Esselmann W Schulz-Shaeffer M Neumann A Schroter P Ratzka L Cepek I Zerr P Steinacker O Windl J Kornhuber HA Kretzschmar S Poser J Wiltfang 2000 Decreased β-amyloid1-42 in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease Neurology 54 1099 1102
42. M Otto P Lewczuk J Wiltfang 2008 Neurochemical approaches of cerebrospinal fluid diagnostics in neurodegenerative diseases Methods 44 289 298
43. M Otto J Wiltfang L Cepek M Neumann B Mollenhauer P Steinacker B Ciesielczyk W Schulz-Schaeffer HA Kretzschmar S Poser 2002 Tau protein and 14-3-3 protein in the differential diagnosis of Creutzfeldt-Jakob disease Neurology 58 192 197
44. M Otto J Wiltfang H Tumani I Zerr M Lantsch J Kornhuber T Weber HA Kretzschmar S Poser 1997 Elevated levels of tau-protein in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease Neurosci Lett 225 210 212
45. RL Ownby E Crocco A Acevedo V John D Loewenstein 2006 Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis Arch Gen Psychiatry 63 530 538
46. L Parnetti A Lanari S Amici V Gallai E Vanmechelen F Hulstaert 2001 CSF phosphorylated tau is a possible marker for discriminating Alzheimer's disease from dementia with Lewy bodies. Phospho-Tau International Study Group Neurol Sci 22 77 78
47. S Ray M Britschgi C Herbert Y Takeda-Uchimura A Boxer K Blennow LF Friedman DR Galasko M Jutel A Karydas JA Kaye J Leszek BL Miller L Minthon JF Quinn GD Rabinovici WH Robinson MN Sabbagh YT So DL Sparks M Tabaton J Tinklenberg JA Yesavage R Tibshirani T Wyss-Coray 2007 Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins Nat Med 13 1359 1362
48. M Riemenschneider M Schmolke N Lautenschlager H Vanderstichele E Vanmechelen WG Guder A Kurz 2002 Association of CSF apolipoprotein E, A[beta]42 and cognition in Alzheimer's disease Neurobiol Aging 23 205 211
49. M Sjögren M Gisslen E Vanmechelen K Blennow 2001 Low cerebrospinal fluid β-amyloid 42 in patients with acute bacterial meningitis and normalization after treatment Neurosci Lett 314 33 36
50. X Sun DC Steffens R Au M Folstein P Summergrad J Yee I Rosenberg DM Mwamburi WQ Qiu 2008 Amyloid-associated depression: a prodromal depression of Alzheimer disease? Arch Gen Psychiatry 65 542 550
51. The Working Group on: "Molecular and Biochemical Markers of Alzheimer's Disease" 1998 Consensus report of the working group on: "Molecular and Biochemical Markers of Alzheimer's Disease". The Ronald and Nancy Reagan Research Institute of the Alzheimer's Association and the National Institute on Aging Working Group Neurobiol Aging 19 109 116
52. M van Oijen A Hofman HD Soares PJ Koudstaal MM Breteler 2006 Plasma Abeta(1-40) and Abeta(1-42) and the risk of dementia: a prospective case-cohort study Lancet Neurol 5 655 660
53. H Vanderstichele E Van Kerschaver C Hesse P Davidsson MA Buyse N Andreasen L Minthon A Wallin K Blennow E Vanmechelen 2000 Standardization of measurement of beta-amyloid(1-42) in cerebrospinal fluid and plasma Amyloid 7 245 258
54. Vanmechelen E, Van Kerschaver E, Blennow K, De Deyn PP, Gartner FH, Parnetti L, Sindic CJM, Arai H, Riemenschneider M, Hampel H, Pottel H, Valgaeren A, Hulstaert F, Vanderstichele H (2001) CSF-Phospho-tau (181P) as a promising marker for discriminating Alzheimer's disease from dementia with Lewy bodies. In: Iqbal K, Sisodia SS, Winblad B (eds) Alzheimer's disease: advances in etiology, pathogenesis and therapeutics. Wiley, Chichester, pp 285-291
55. J Wiltfang H Esselmann M Bibl M Hull H Hampel H Kessler L Frolich J Schroder O Peters F Jessen C Luckhaus R Perneczky H Jahn M Fiszer JM Maler R Zimmermann R Bruckmoser J Kornhuber P Lewczuk 2007 Amyloid beta peptide ratio 42/40 but not A beta 42 correlates with phospho-Tau in patients with low- and high-CSF A beta 40 load J Neurochem 101 1053 1059
56. J Wiltfang H Esselmann P Cupers M Neumann H Kretzschmar M Beyermann D Schleuder H Jahn E Rüther J Kornhuber W Annaert B De Strooper P Saftig 2001 Elevation of β-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells J Biol Chem 276 42645 42657
57. J Wiltfang H Esselmann A Smirnov M Bibl L Cepek P Steinacker B Mollenhauer K Buerger H Hampel S Paul M Neumann M Maler I Zerr J Kornhuber HA Kretzschmar S Poser M Otto 2003 β-amyloid peptides in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease Ann Neurol 54 263 267
58. I Zerr M Bodemer O Gefeller M Otto S Poser J Wiltfang O Windl HA Kretzschmar T Weber 1998 Detection of 14-3-3 protein in the cerebrospinal fluid supports the diagnosis of Creutzfeldt-Jakob disease Ann Neurol 43 32 40
59. H Zetterberg LO Wahlund K Blennow 2003 Cerebrospinal fluid markers for prediction of Alzheimer's disease Neurosci Lett 352 67 69