Irsogladine maleate suppresses indomethacin-induced elevation of proinflammatory cytokines and gastric injury in rats

World Journal of Gastroenterology

Volumn 14, Issue 30, 2008, Pages 4784-4790

  Zhang, Xin ^a   Tajima, Koyuki ^a   Kageyama, Kiyoto ^a   Kyoi, Takashi ^a  

^a NIPPON SHINYAKU CO LTD   (Japan)

Author keywords

Cytokine; Gastric injury; Indomethacin; Irsogladine; Myeloperoxidase

Indexed keywords

ANTIULCER AGENT; INDOMETACIN; INTERLEUKIN 1BETA; INTERLEUKIN 8; IRSOGLADINE MALEATE; MYELOPEROXIDASE; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; IRSOGLADINE; PEROXIDASE; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV; TRIAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MECHANISM; MALE; MUCOSA INFLAMMATION; NEUTROPHIL CHEMOTAXIS; NONHUMAN; RAT; STOMACH MUCOSA INJURY; STOMACH MUCOSA LESION; STOMACH PROTECTION; ANIMAL; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; IMMUNOLOGY; METABOLISM; PATHOLOGY; STOMACH MUCOSA; STOMACH ULCER; TIME;

ANIMALS; ANTI-ULCER AGENTS; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; CYTOKINES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GASTRIC MUCOSA; INDOMETHACIN; INTERLEUKIN-1BETA; INTERLEUKIN-8; MALE; PEROXIDASE; PHOSPHODIESTERASE INHIBITORS; RATS; STOMACH ULCER; TIME FACTORS; TRIAZINES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 55449119185     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.14.4784     Document Type: Article

References (29)

1. Simmons DL, Botting RM, Hla T. Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition. Pharmacol Rev 2004; 56: 387-437
2. Wolfe MM, Lichtenstein DR, Singh G. Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. N Engl J Med 1999; 340: 1888-1899
3. Singh G, Ramey DR, Morfeld D, Shi H, Hatoum HT, Fries JF. Gastrointestinal tract complications of nonsteroidal anti-inflammatory drug treatment in rheumatoid arthritis. A prospective observational cohort study. Arch Intern Med 1996; 156: 1530-1536
4. Yoshikawa T, Naito Y, Kishi A, Tomii T, Kaneko T, Iinuma S, Ichikawa H, Yasuda M, Takahashi S, Kondo M. Role of active oxygen, lipid peroxidation, and antioxidants in the pathogenesis of gastric mucosal injury induced by indomethacin in rats. Gut 1993; 34: 732-737
5. Okada A, Kinoshita Y, Waki S, Fukui H, Maekawa T, Matsushima Y, Kawanami C, Kishi K, Nakata H, Wang HY, Hassan S, Chiba T. Rat gastric mucosal cells express ICAM-1 and proinflammatory cytokines during indomethacin-induced mucosal injury. J Lab Clin Med 1998; 131: 538-547
6. Wallace JL, Keenan CM, Granger DN. Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process. Am J Physiol 1990; 259: G462-G467
7. Ueda F, Aratani S, Mimura K, Kimura K, Nomura A, Enomoto H. Effect of 2,4-diamino-6-(2,5-dichlorophenyl)- s-triazine maleate (MN-1695) on gastric ulcers and gastric secretion in experimental animals. Arzneimittelforschung 1984; 34: 474-477
8. Ueda F, Aratani S, Mimura K, Kimura K, Nomura A, Enomoto H. Effect of 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate (MN-1695) on gastric mucosal damage induced by various necrotizing agents in rats. Arzneimittelforschung 1984; 34: 478-484
9. Kyoi T, Oka M, Noda K, Ukai Y. Irsogladine prevents monochloramine-induced gastric mucosal lesions by improving the decrease in mucosal blood flow due to the disturbance of nitric oxide synthesis in rats. J Pharmacol Sci 2003; 93: 314-320
10. Kamei K, Kubo Y, Kato N, Hatazawa R, Amagase K, Takeuchi K. Prophylactic Effect of Irsogladine Maleate Against Indomethacin-Induced Small Intestinal Lesions in Rats. Dig Dis Sci 2008
11. Kyoi T, Oka M, Noda K, Ukai Y. Phosphodiesterase inhibition by a gastroprotective agent irsogladine: preferential blockade of cAMP hydrolysis. Life Sci 2004; 75: 1833-1842
12. Kyoi T, Noda K, Oka M, Ukai Y. Irsogladine, an anti-ulcer drug, suppresses superoxide production by inhibiting phosphodiesterase type 4 in human neutrophils. Life Sci 2004; 76: 71-83
13. Kyoi T, Kitazawa S, Tajima K, Zhang X, Ukai Y. Phosphodiesterase type IV inhibitors prevent ischemiareperfusion-induced gastric injury in rats. J Pharmacol Sci 2004; 95: 321-328
14. Klemm P, Harris HJ, Perretti M. Effect of rolipram in a murine model of acute inflammation: comparison with the corticoid dexamethasone. Eur J Pharmacol 1995; 281: 69-74
15. Kasyapa CS, Stentz CL, Davey MP, Carr DW. Regulation of IL-15-stimulated TNF-alpha production by rolipram. J Immunol 1999; 163: 2836-2843
16. Sanz MJ, Cortijo J, Taha MA, Cerda-Nicolas M, Schatton E, Burgbacher B, Klar J, Tenor H, Schudt C, Issekutz AC, Hatzelmann A, Morcillo EJ. Roflumilast inhibits leukocyte-endothelial cell interactions, expression of adhesion molecules and microvascular permeability. Br J Pharmacol 2007; 152: 481-492
17. Watanabe T, Higuchi K, Hamaguchi M, Shiba M, Tominaga K, Fujiwara Y, Matsumoto T, Arakawa T. Monocyte chemotactic protein-1 regulates leukocyte recruitment during gastric ulcer recurrence induced by tumor necrosis factor-alpha. Am J Physiol Gastrointest Liver Physiol 2004; 287: G919-G928
18. Yoshikawa T, Takano H, Naito Y, Oyamada H, Ueda S, Kondo M. Augmentative effects of tumor necrosis factor-alpha (human, natural type) on polymorphonuclear leukocyte-derived superoxide generation induced by various stimulants. Int J Immunopharmacol 1992; 14: 1391-1398
19. Kokura S, Wolf RE, Yoshikawa T, Granger DN, Aw TY. T-lymphocyte-derived tumor necrosis factor exacerbates anoxia-reoxygenation-induced neutrophil-endothelial cell adhesion. Circ Res 2000; 86: 205-213
20. Kahky MP, Daniel CO, Cruz AB, Gaskill HV 3rd. Portal infusion of tumor necrosis factor increases mortality in rats. J Surg Res 1990; 49: 138-145
21. Toroudi HP, Rahgozar M, Bakhtiarian A, Djahanguiri B. Potassium channel modulators and indomethacin-induced gastric ulceration in rats. Scand J Gastroenterol 1999; 34: 962-966
22. Santucci L, Fiorucci S, Giansanti M, Brunori PM, Di Matteo FM, Morelli A. Pentoxifylline prevents indomethacin induced acute gastric mucosal damage in rats: role of tumour necrosis factor alpha. Gut 1994; 35: 909-915
23. Santucci L, Fiorucci S, Di Matteo FM, Morelli A. Role of tumor necrosis factor alpha release and leukocyte margination in indomethacin-induced gastric injury in rats. Gastroenterology 1995; 108: 393-401
24. Hamlet A, Lindholm C, Nilsson O, Olbe L. Aspirin-induced gastritis, like Helicobacter pylori-induced gastritis disinhibits acid secretion in humans: relation to cytokine expression. Scand J Gastroenterol 1998; 33: 346-356
25. Tanaka J, Yuda Y, Yamakawa T. Mechanism of superoxide generation system in indomethacin-induced gastric mucosal injury in rats. Biol Pharm Bull 2001; 24: 155-158
26. Odashima M, Otaka M, Jin M, Komatsu K, Wada I, Horikawa Y, Matsuhashi T, Hatakeyama N, Oyake J, Ohba R, Watanabe S, Linden J. Attenuation of gastric mucosal inflammation induced by aspirin through activation of A2A adenosine receptor in rats. World J Gastroenterol 2006; 12: 568-573
27. Wallace JL. Nonsteroidal anti-inflammatory drugs and gastroenteropathy: the second hundred years. Gastroenterology 1997; 112: 1000-1016
28. Anthony A, Sim R, Dhillon AP, Pounder RE, Wakefield AJ. Gastric mucosal contraction and vascular injury induced by indomethacin precede neutrophil infiltration in the rat. Gut 1996; 39: 363-368
29. Nakamura C, Otaka M, Odashima M, Jin M, Konishi N, Horikawa Y, Matsuhashi T, Watanabe S. Rolipram, a specific type IV phosphodiesterase inhibitor, ameliorates indomethacin-induced gastric mucosal injury in rats. Pathophysiology 2003; 9: 195-200