Prophylactic effect of irsogladine maleate against indomethacin-induced small intestinal lesions in rats

Digestive Diseases and Sciences

Volumn 53, Issue 10, 2008, Pages 2657-2666

  Kamei, Kohei ^a   Kubo, Yoshikazu ^a   Kato, Naho ^a   Hatazawa, Ryo ^a   Amagase, Kikuko ^a   Takeuchi, Koji ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Indomethacin induced small intestinal lesion; Irsogladine; Mucosal protective drug; Phosphodiesterase type IV; Rat

Indexed keywords

AMPICILLIN; INDOMETACIN; INDUCIBLE NITRIC OXIDE SYNTHASE; IRSOGLADINE MALEATE; PHOSPHODIESTERASE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; INTESTINE INJURY; MALE; MUCUS SECRETION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTI-ULCER AGENTS; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; DISEASE MODELS, ANIMAL; ENTEROBACTERIACEAE; GASTROINTESTINAL MOTILITY; ILEAL DISEASES; INDOMETHACIN; INTESTINAL DISEASES; INTESTINAL MUCOSA; JEJUNAL DISEASES; MALE; NITRIC OXIDE SYNTHASE TYPE II; PEROXIDASE; RATS; RATS, SPRAGUE-DAWLEY; TRIAZINES; ULCER;

EID: 50949093817     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-008-0199-9     Document Type: Article

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