Phosphodiesterase inhibition by a gastroprotective agent irsogladine: Preferential blockade of cAMP hydrolysis

Life Sciences

Volumn 75, Issue 15, 2004, Pages 1833-1842

  Kyoi, Takashi ^a   Oka, Michiko ^a   Noda, Kumiko ^a   Ukai, Yojiro ^a  

^a NIPPON SHINYAKU CO LTD   (Japan)

Author keywords

cAMP; Gastroprotection; Irsogladine; Phosphodiesterase

Indexed keywords

9 (2 HYDROXY 3 NONYL)ADENINE; ANTIULCER AGENT; BRAIN ENZYME; CILOSTAMIDE; CYCLIC AMP; CYCLIC GMP; CYCLIC NUCLEOTIDE; HEART ENZYME; IRSOGLADINE MALEATE; ISOBUTYLMETHYLXANTHINE; ISOENZYME; PHOSPHODIESTARASE 2 INHIBITOR; PHOSPHODIESTERASE; PHOSPHODIESTERASE 1 INHIBITOR; PHOSPHODIESTERASE III INHIBITOR; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV INHIBITOR; ROLIPRAM; UNCLASSIFIED DRUG; VINPOCETINE;

ANIMAL TISSUE; ARTICLE; BRAIN; CATTLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEGRADATION; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG SELECTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; HEART; HYDROLYSIS; INHIBITION KINETICS; MALE; MEASUREMENT; NONHUMAN; PROTEIN PURIFICATION; RAT; STOMACH; STOMACH PROTECTION;

1-METHYL-3-ISOBUTYLXANTHINE; ANIMALS; ANTI-ULCER AGENTS; BRAIN; CATTLE; CYCLIC AMP; CYCLIC GMP; HYDROLYSIS; ISOENZYMES; MALE; MYOCARDIUM; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; RATS; RATS, SPRAGUE-DAWLEY; STOMACH; TRIAZINES;

BOVINAE;

EID: 4043158547     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2004.03.022     Document Type: Article

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