Coenzyme Q1 redox metabolism during passage through the rat pulmonary circulation and the effect of hyperoxia

Journal of Applied Physiology

Volumn 105, Issue 4, 2008, Pages 1114-1126

  Audi, Said H ^a,c,d   Merker, Marilyn P ^c,d   Krenz, Gary S ^b   Ahuja, Taniya ^a   Roerig, David L ^c,d   Bongard, Robert D ^c  

^a Marquette University

^b MARQUETTE UNIVERSITY   (United States)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

^d CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Mathematical modeling; NAD(P)H: quinone oxidoreductase 1; NADH: ubiquinone oxidoreductase; Ubiquinol cytochrome c oxidoreductase

Indexed keywords

DICOUMAROL; DIPEPTIDYL CARBOXYPEPTIDASE; HYDROQUINONE; MITOCHONDRIAL COMPLEX 2; OXIDOREDUCTASE; ROTENONE; UBIQUINOL CYTOCHROME C REDUCTASE; UBIQUINONE; UBIQUINONE HOMOLOG COENZYME; UNCLASSIFIED DRUG; ENZYME INHIBITOR; NQO1 PROTEIN, RAT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); UBIQUINONE Q1;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME METABOLISM; HYPEROXIA; KINETICS; LUNG CAPACITY; LUNG CIRCULATION; LUNG PERFUSION; LUNG PRESSURE; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; ANIMAL; BIOLOGICAL MODEL; BLOOD; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; LUNG; METABOLISM; MITOCHONDRION; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT; VASCULARIZATION;

ANIMALS; DISEASE MODELS, ANIMAL; ELECTRON TRANSPORT COMPLEX I; ELECTRON TRANSPORT COMPLEX III; ENZYME INHIBITORS; HYPEROXIA; KINETICS; LUNG; MITOCHONDRIA; MODELS, CARDIOVASCULAR; NAD(P)H DEHYDROGENASE (QUINONE); OXIDATION-REDUCTION; OXIDOREDUCTASES; PULMONARY CIRCULATION; RATS; RATS, SPRAGUE-DAWLEY; UBIQUINONE;

EID: 55449085551     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00177.2008     Document Type: Article

References (63)

1. Anusevicius Z, Sarlauskas J, Cenas N. Two-electron reduction of quinones by rat liver NAD(P)H:quinone oxidoreductase: quantitative structure-activity relationships. Arch Biochem Biophys 404: 254-262, 2002.
2. Audi SH, Bongard RD, Dawson CA, Siegel D, Roerig DL, Merker MP. Duroquinone reduction during passage through the pulmonary circulation. Am J Physiol Lung Cell Mol Physiol 285: L1116-L1131, 2003.
3. Audi SH, Bongard RD, Krenz GS, Rickaby DA, Haworth ST, Eisenhauer J, Roerig DL, Merker MP. Effect of chronic hyperoxic exposure on duroquinone reduction in adult rat lungs. Am J Physiol Lung Cell Mol Physiol 289: L788-L797, 2005.
4. Audi SH, Bongard RD, Okamoto Y, Merker MP, Roerig DL, Dawson CA. Pulmonary reduction of an intravascular redox polymer. Am J Physiol Lung Cell Mol Physiol 280: L1290-L1299, 2001.
5. Audi SH, Dawson CA, Ahlf SB, Roerig DL. Oxygen dependency of monoamine oxidase activity in the intact lung. Am J Physiol Lung Cell Mol Physiol 281: L969-L981, 2001.
6. Audi SH, Dawson CA, Linehan JH, Krenz GS, Ahlf SB, Roerig DL. Pulmonary disposition of lipophilic amine compounds in the isolated perfused rabbit lung. J Appl Physiol 84: 516-530, 1998.
7. Audi SH, Linehan JH, Krenz GS, Dawson CA. Accounting for the heterogeneity of capillary transit times in modeling multiple indicator dilution data. Ann Biomed Eng 26: 914-930, 1998.
8. Audi SH, Linehan JH, Krenz GS, Dawson CA, Ahlf SB, Roerig DL. Estimation of the pulmonary capillary transport function in isolated rabbit lungs. J Appl Physiol 78: 1004-1014, 1995.
9. Audi SH, Olson LE, Bongard RD, Roerig DL, Schulte ML, Dawson CA. Toluidine blue O and methylene blue as endothelial redox probes in the intact lung. Am J Physiol Heart Circ Physiol 278: H137-H150, 2000.
10. Audi SH, Zhao H, Bongard RD, Hogg N, Kettenhofen NJ, Kalyanaraman B, Dawson CA, Merker MP. Pulmonary arterial endothelial cells affect the redox status of coenzyme Q0. Free Radic Biol Med 34: 892-907, 2003.
11. Barrientos A, Moraes CT. Titrating the effects of mitochondrial complex I impairment in the cell physiology. J Biol Chem 274: 16188-16197, 1999.
12. Bassingthwaighte JB, Goresky CA, Linehan JH. (editors). Whole Organ Approaches to Cellular Metabolism: Permeation, Cellular Uptake, and Product Formation. New York: Springer, 1998.
13. Beard DA, Bassingthwaighte JB, Greene AS. Computational modeling of physiological systems. Physiol Genomics 23: 1-4, 2005.
14. Beyer RE, Segura-Aguilar J, Di Bernardo S, Cavazzoni M, Fato R, Fiorentini D, Galli MC, Setti M, Landi L, Lenaz G. The role of DT-diaphorase in the maintenance of the reduced antioxidant form of coenzyme Q in membrane systems. Proc Natl Acad Sci USA 93: 2528-2532, 1996.
15. Block ER, Fisher AB. Depression of serotonin clearance by rat lungs during oxygen exposure. J Appl Physiol 42: 33-38, 1977.
16. Bongard RD, Krenz GS, Linehan JH, Roerig DL, Merker MP, Widell JL, Dawson CA. Reduction and accumulation of methylene blue by the lung. J Appl Physiol 77: 1480-1491, 1994.
17. Bongard RD, Merker MP, Shundo R, Okamoto Y, Roerig DL, Linehan JH, Dawson CA. Reduction of thiazine dyes by bovine pulmonary arterial endothelial cells in culture. Am J Physiol Lung Cell Mol Physiol 269: L78-L84, 1995.
18. Brueckl C, Kaestle S, Kerem A, Habazettl H, Krombach F, Kuppe H, Kuebler WM. Hyperoxia-induced reactive oxygen species formation in pulmonary capillary endothelial cells in situ. Am J Respir Cell Mol Biol 34: 453-463, 2006.
19. Budinger GR, Sznajder JI. To live or die: a critical decision for the lung. J Clin Invest 115: 828-830, 2005.
20. Cadenas E. Antioxidant and prooxidant functions of DT-diaphorase in quinone metabolism. Biochem Pharmacol 49: 127-140, 1995.
21. Cadenas E, Boveris A, Ragan CI, Stoppani AO. Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria. Arch Biochem Biophys 180: 248-257, 1977.
22. Campian JL, Qian M, Gao X, Eaton JW. Oxygen tolerance and coupling of mitochondrial electron transport. J Biol Chem 279: 46580-46587, 2004.
23. Chan TS, Teng S, Wilson JX, Galati G, Khan S, O'Brien PJ. Coenzyme Q cytoprotective mechanisms for mitochondrial complex I cytopathies involves NAD(P)H: quinone oxidoreductase 1(NQO1). Free Radic Res 36: 421-427, 2002.
24. Chen YR, Chen CL, Zhang L, Green-Church KB, Zweier JL. Superoxide generation from mitochondrial NADH dehydrogenase induces self-inactivation with specific protein radical formation. J Biol Chem 280: 37339-37348, 2005.
25. Cho HY, Jedlicka AE, Reddy SP, Kensler TW, Yamamoto M, Zhang LY, Kleeberger SR. Role of NRF2 in protection against hyperoxic lung injury in mice. Am J Respir Cell Mol Biol 26: 175-182, 2002.
26. Crapo JD, Barry BE, Foscue HA, Shelburne J. Structural and biochemical changes in rat lungs occurring during exposures to lethal and adaptive doses of oxygen. Am Rev Respir Dis 122: 123-143, 1980.
27. Dawson CA, Audi SH, Bongard RD, Okamoto Y, Olson L, Merker MP. Transport and reaction at endothelial plasmalemma: distinguishing intra- from extracellular events. Ann Biomed Eng 28: 1010-1018, 2000.
28. Dawson CA, Audi SH, Krenz GS, Roerig DL. Endothelium and Compound Transfer. In: Molecular Nuclear Medicine: The Challenge of Genomics and Proteomics to Clinical Practice, edited by Feinendegen LE, Eckelman WC, Bahk YW, and Wagner Jr. HN. New York: Springer, 2003, p. 201-216.
29. Degli Esposti M, Ngo A, McMullen GL, Ghelli A, Sparla F, Benelli B, Ratta M, Linnane AW. The specificity of mitochondrial complex I for ubiquinones. Biochem J 313: 327-334, 1996.
30. + pump by exogenous quinones in intact mitochondria. J Biol Chem 257: 4106-4113, 1982.
31. Dinkova-Kostova AT, Talalay P. Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen. Free Radic Biol Med 29: 231-240, 2000.
32. Dragan M, Dixon SJ, Jaworski E, Chan TS, O'Brien PJ, Wilson JX. Coenzyme Q(1) depletes NAD(P)H and impairs recycling of ascorbate in astrocytes. Brain Res 1078: 9-18, 2006.
33. Faig M, Bianchet MA, Talalay P, Chen S, Winski S, Ross D, Amzel LM. Structures of recombinant human and mouse NAD(P)H:quinone oxidoreductases: species comparison and structural changes with substrate binding and release. Proc Natl Acad Sci USA 97: 3177-3182, 2000.
34. Fato R, Bernardo SD, Estornell E, Parentic Castelli G, Lenaz G. Saturation kinetics of coenzyme Q in NADH oxidation: rate enhancement by incorporation of excess quinone. Mol Aspects Med 18, Suppl: S269-S273, 1997.
35. Fato R, Estornell E, Di Bernardo S, Pallotti F, Parenti Castelli G, Lenaz G. Steady-state kinetics of the reduction of coenzyme Q analogs by complex I (NADH:ubiquinone oxidoreductase) in bovine heart mitochondria and submitochondrial particles. Biochemistry 35: 2705-2716, 1996.
36. 2. J Appl Physiol 45: 56-59, 1978.
37. Freeman BA, Crapo JD. Hyperoxia increases oxygen radical production in rat lungs and lung mitochondria. J Biol Chem 256: 10986-10992, 1981.
38. Haugaard N. Cellular mechanisms of oxygen toxicity. Physiol Rev 48: 311-373, 1968.
39. Huet S, Bouvier A, Pourat MA, Jolivet E. Statistical Tools For Nonlinear Regression. New York: Springer, 2004.
40. Jaiswal AK. Regulation of genes encoding NAD(P)H:quinone oxidoreductases. Free Radic Biol Med 29: 254-262, 2000.
41. Kadokura H, Bader M, Tian H, Bardwell JC, Beckwith J. Roles of a conserved arginine residue of DsbB in linking protein disulfide-bond-formation pathway to the respiratory chain of Escherichia coli. Proc Natl Acad Sci USA 97: 10884-10889, 2000.
42. Kauten R, Tsai AL, Palmer G. The kinetics of reduction of yeast complex III by a substrate analog. J Biol Chem 262: 8658-8667, 1987.
43. 2. Am Rev Respir Dis 118: 622-625, 1978.
44. Landaw EM, DiStefano JJ 3rd. Multiexponential, multicompartmental, and noncompartmental modeling. II. Data analysis and statistical considerations. Am J Physiol Regul Integr Comp Physiol 246: R665-R677, 1984.
45. Lenaz G. Quinone specificity of complex I. Biochim Biophys Acta 1364: 207-221, 1998.
46. Lenaz G, Fato R, Baracca A, Genova ML. Mitochondrial quinone reductases: complex I. Methods Enzymol 382: 3-20, 2004.
47. Merker MP, Audi SH, Bongard RD, Lindemer BJ, Krenz GS. Influence of pulmonary arterial endothelial cells on quinone redox status: effect of hyperoxia induced NAD(P)H:quinone oxidoreductase 1 (NQO1). Am J Physiol Lung Cell Mol Physiol 290: L607-L619, 2006.
48. Merker MP, Audi SH, Lindemer BJ, Krenz GS, Bongard RD. Role of mitochondrial electron transport complex I in coenzyme Q1 reduction by intact pulmonary arterial endothelial cells and the effect of hyperoxia. Am J Physiol Lung Cell Mol Physiol 293: L809-L819, 2007.
49. Merker MP, Bongard RD, Kettenhofen NJ, Okamoto Y, Dawson CA. Intracellular redox status affects transplasma membrane electron transport in pulmonary arterial endothelial cells. Am J Physiol Lung Cell Mol Physiol 282: L36-L43, 2002.
50. Merker MP, Bongard RD, Krenz GS, Zhao H, Fernandes VS, Kalyanaraman B, Hogg N, Audi SH. Impact of pulmonary arterial endothelial cells on duroquinone redox status. Free Radic Biol Med 37: 86-103, 2004.
51. Merker MP, Bongard RD, Linehan JH, Okamoto Y, Vyprachticky D, Brantmeier BM, Roerig DL, Dawson CA. Pulmonary endothelial thiazine uptake: separation of cell surface reduction from intracellular reoxidation. Am J Physiol Lung Cell Mol Physiol 272: L673-L680, 1997.
52. Rauchova H, Fato R, Drahota Z, Lenaz G. Steady-state kinetics of reduction of coenzyme Q analogs by glycerol-3-phosphate dehydrogenase in brown adipose tissue mitochondria. Arch Biochem Biophys 344: 235-241, 1997.
53. Rich PR, Harper R. Partition coefficients of quinones and hydroquinones and their relation to biochemical reactivity. FEBS Lett 269: 139-144, 1990.
54. Sanders SP, Zweier JL, Kuppusamy P, Harrison SJ, Bassett DJ, Gabrielson EW, Sylvester JT. Hyperoxic sheep pulmonary microvascular endothelial cells generate free radicals via mitochondrial electron transport. J Clin Invest 91: 46-52, 1993.
55. Schwab AJ, Goresky CA. Hepatic uptake of protein-bound ligands: effect of an unstirred Disse space. Am J Physiol Gastrointest Liver Physiol 270: G869-G880, 1996.
56. Siegel D, Gustafson DL, Dehn DL, Han JY, Boonchoong P, Berliner LJ, Ross D. NAD(P)H:quinone oxidoreductase 1: role as a superoxide scavenger. Mol Pharmacol 65: 1238-1247, 2004.
57. Stocker R, Suarna C. Extracellular reduction of ubiquinone-1 and -10 by human Hep G2 and blood cells. Biochim Biophys Acta 1158: 15-22, 1993.
58. Storrie B, Madden EA. Isolation of subcellular organelles. Methods Enzymol 182: 203-225, 1990.
59. Turrens JF. Mitochondrial formation of reactive oxygen species. J Physiol 552: 335-344, 2003.
60. Waters CM. Reactive oxygen species in mechanotransduction. Am J Physiol Lung Cell Mol Physiol 287: L484-L485, 2004.
61. Weiss M, Kang W. P-glycoprotein inhibitors enhance saturable uptake of idarubicin in rat heart: pharmacokinetic/pharmacodynamic modeling. J Pharmacol Exp Ther 300: 688-694, 2002.
62. Wright MV, Kuhn TB. CNS neurons express two distinct plasma membrane electron transport systems implicated in neuronal viability. J Neurochem 83: 655-664, 2002.
63. Zierhut ML, Gardner JC, Spilker ME, Sharp JT, Vicini P. Kinetic modeling of contrast-enhanced MRI: an automated technique for assessing inflammation in the rheumatoid arthritis wrist. Ann Biomed Eng 35: 781-795, 2007.