P-glycoprotein inhibitors enhance saturable uptake of idarubicin in rat heart: Pharmacokinetic/pharmacodynamic modeling

Journal of Pharmacology and Experimental Therapeutics

Volumn 300, Issue 2, 2002, Pages 688-694

  Weiss, Michael ^a   Kang, Wonku ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMIODARONE; GLYCOPROTEIN P; IDARUBICIN; VERAPAMIL;

ANIMAL TISSUE; ARTICLE; CARDIOTOXICITY; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG UPTAKE; HEART LEFT VENTRICLE PRESSURE; INOTROPISM; ISOLATED HEART; MALE; NONHUMAN; NONLINEAR REGRESSION ANALYSIS; PRIORITY JOURNAL; RAT; TOXICOKINETICS; TRANSPORT KINETICS;

ALGORITHMS; AMIODARONE; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CALCIUM CHANNEL BLOCKERS; DEPRESSION, CHEMICAL; ENZYME INHIBITORS; HEART; HEART RATE; IDARUBICIN; KINETICS; MALE; MODELS, BIOLOGICAL; MYOCARDIUM; NONLINEAR DYNAMICS; P-GLYCOPROTEIN; RATS; RATS, SPRAGUE-DAWLEY; VERAPAMIL;

EID: 0036156298     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.300.2.688     Document Type: Article

References (37)

1. P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain
2. 3H]daunomycin and MDR reversing agents
3. Distribution and activity of doxorubicin combined with SDZ PSC 833 in mice with P388 and P388/DOX leukaemia
4. P-glycoprotein is more efficient at limiting uptake than inducing efflux of colchicine and vinblastine in HL-60 cells
5. 1 kidney epithelial cell line
6. Effect of PSC 833, verapamil and amiodarone on adriamycin toxicity in cultured rat cardiomyocytes
7. Biochemistry of multidrug resistance mediated by the multidrug transporter
8. Understanding the dose-effect relationship: Clinical application of pharmacokinetic-pharmacodynamic models
9. Patterns of interaction between anthraquinone drugs and the calcium-release channel from cardiac sarcoplasmic reticulum
10. Evaluation of a minimal experimental design for determination of enzyme kinetic parameters and inhibition mechanism
11. Influence of P-glycoprotein modulators on cardiac uptake, metabolism, and effects of idarubicin
12. Comparative intracellular uptake of adriamycin and 4′-deoxydoxorubicin by non-small cell lung tumor cells in culture and ist relationship to cell survival
13. Anti-arrhythmic effect of amiodarone on doxorubicin acute toxicity in working rat hearts
14. Resistance mechanisms associated with altered intracellular distribution of anticancer agents
15. A calcium antagonist protects against doxorubicin-induced impairment of calcium handling in neonatal rat cardiac myocytes
16. Pharmacodynamic modeling of time-dependent transduction systems
17. 2+ handling
18. Transport mechanism of anthracycline derivatives in human leukemia cell lines: Uptake and efflux of pirarubicin in HL60 and pirarubicin-resistant HL60 cells
19. Transport mechanisms of idarubicin, an anthracycline derivative, in human leukemia HL60 cells and mononuclear cells, and comparison with those of its analogs
20. Influx of daunorubicin in multidrug resistant Ehrlich ascites tumour cells: Correlation to expression of P-glycoprotein and efflux. Influence of verapamil
21. Sarcoplasmic reticulum calcium release is stimulated and inhibited by daunorubicin and daunorubicinol
22. Pharmacokinetic-pharmacodynamic modeling of the anticonvulsant and electroencephalogram effects of phenytoin in rats
23. P-Glycoprotein in clinical cardiology
24. 1
25. Carrier-mediated transport of daunorubicin, adriamycin, and rubidazone in Ehrlich ascites tumour cells
26. Kinetics of the multidrug transporter (P-glycoprotein) and its reversal
27. 2- loading and inotropic effects of doxorubicin in atrial muscle preparations isolated from rat or guinea-pig hearts
28. 2+ sensitivity of contractile proteins
29. The uptake and efflux of doxorubicin by a sensitive human bladder cancer cell line and doxorubicin-resistant subline
30. Comparative pharmacokinetics of vinblastine after a 96-hour continuous infusion in wild-type mice and mice lacking mdrla P-glycoprotein
31. Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdrla P-glycoprotein
32. Distribution of multi-drug resistance-associated P-glycoprotein in normal and neoplastic human tissues
33. 2+ exchange current in guinea-pig cardiac myocytes
34. Pharmacokinetics in organs and the intact body: Model validation and reduction
35. The relative importance of passive and P-glycoprotein mediated anthracycline efflux from multidrug-resistant cells