Apoptotic pulsed dendritic cells induce a protective immune response against Toxoplasma gondii

Parasite Immunology

Volumn 30, Issue 11-12, 2008, Pages 620-629

  Bertaux, L ^a   Mevelec, M N ^a   Dion, S ^a   Suraud, V ^a   Gregoire, M ^b   Berthon, P ^b   Dimier Poisson, I ^a,c  

^a UNIVERSITÉ DE TOURS   (France)

^b UR1282   (France)

^c UFR des Sciences Pharmaceutiques   (France)

Author keywords

Apoptosis; Dendritic cell; Immunization; Toxoplasma gondii

Indexed keywords

ANTIGEN; DENDRITIC CELL VACCINE; HEAT SHOCK PROTEIN 70;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; FEASIBILITY STUDY; FEMALE; HISTOPATHOLOGY; HUMORAL IMMUNITY; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TOXOPLASMA GONDII; TOXOPLASMOSIS;

ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES, PROTOZOAN; APOPTOSIS; CELL PROLIFERATION; CELLS, CULTURED; CYTOKINES; DENDRITIC CELLS; FEMALE; LEUKOCYTES, MONONUCLEAR; LYMPH NODES; MICE; MICE, INBRED CBA; SPLEEN; TOXOPLASMA; TOXOPLASMOSIS; VACCINATION;

MUS; PROTOZOA; TOXOPLASMA; TOXOPLASMA GONDII;

EID: 55349120542     PISSN: 01419838     EISSN: 13653024     Source Type: Journal    
DOI: 10.1111/j.1365-3024.2008.01064.x     Document Type: Article

References (28)

1. Ruiz S, Beauvillain C, Breton P, Bout D Dimier-Poisson I. A novel CD8α + murine dendritic cell line confers syngeneic and allogenic vaccine-mediated protection against parasitic infection. Cell Microbiol 2005 11 : 1659 1671.
2. Banchereau J Steinman RM. Dendritic cells and the control of immunity. Nature 1998 392 : 245 252.
3. Albert ML, Sauter B Bhardwaj N. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 1998 392 : 86 89.
4. Blachère N, Darnell R Albert M. Apoptotic cells deliver processed antigen to dendritic cells for cross-presentation. PLoS Biol 2005 185 : 1070 1078.
5. Agrewala JN, Suvas S, Singh V Vohra H. Delivery of antigen in allogeneic cells preferentially generates CD (4+) Th1 cells. Clin Exp Immunol 2003 134 : 13 22.
6. Matzinger P. Tolerance, danger, and the extended family. Annu Rev Immunol 1994 12 : 991 1045.
7. Feng H, Zeng Y, Graner MW Katsanis E. Stressed apoptotic tumor cells stimulate dendritic cells and induce specific cytotoxic T cells. Blood 2002 100 : 4108 4115.
8. Shi Y, Zheng W Rock KL. Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses. Proc Natl Acad Sci USA 2000 97 : 14590 14595.
9. Chardes T, Bourguin I, Mevelec MN, Dubremetz JF Bout D. Antibody responses to Toxoplasma gondii in sera, intestinal secretions, and milk from orally infected mice and characterization of target antigens. Infect Immun 1990 58 : 1240 1246.
10. Dimier-Poisson I, Aline F, Mevelec MN, Beauvillain C, Buzoni-Gatel D Bout D. Protective mucosal Th2 immune response against Toxoplasma gondii by murine mesenteric lymph node dendritic cells. Infect Immun 2003 71 : 5254 5265.
11. Tesniere A, Panaretakis T, Kepp O, et al. Molecular characteristics of immunogenic cancer cell death. Cell Death Differ 2008 15 : 3 12.
12. Feng H, Zeng Y, Graner MW, Likhacheva A Katsanis E. Exogenous stress proteins enhance the immunogenicity of apoptotic tumor cells and stimulate antitumor immunity. Blood 2003 101 : 245 252.
13. McBride S, Hoebe K, Georgel P Janssen E. Cell-associated double-stranded RNA enhances antitumor activity through the production of type I IFN. J Immunol 2006 177 : 6122 6128.
14. Shi Y Rock KL. Cell death releases endogenous adjuvants that selectively enhance immune surveillance of particulate antigens. Eur J Immunol 2002 32 : 155 162.
15. Gazzinelli RT, Wysocka M, Hieny S, et al. In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-γ and TNF-α. J Immunol 1996 157 : 798 805.
16. Khan IA, Ely KH Kasper LH. Antigen-specific CD8+ T cell clone protects against acute Toxoplasma gondii infection in mice. J Immunol 1994 152 : 1856 1860.
17. d-restricted resistance to Toxoplasmic encephalitis and their critical dependence on parasite strain. J Immunol 2002 169 : 966 973.
18. Henry F, Boisteau O, Bretaudeau L, Lieubeau B, Meflah K Gregoire M. Antigen-presenting cells that phagocytose apoptotic tumor-derived cells are potent tumor vaccines. Cancer Res 1999 59 : 3329 3332.
19. Fonteneau JF, Kavanagh DG, Lirvall M, et al. Characterization of the MHC class I cross-presentation pathway for cell-associated antigens by human dendritic cells. Blood 2003 102 : 4448 4455.
20. Rovere P, Vallinoto C, Bondanza A, et al. Bystander apoptosis triggers dendritic cell maturation and antigen-presenting function. J Immunol 1998 161 : 4467 4471.
21. Araujo FG. Depletion of L3T4+ (CD4+) lymphocytes-T prevents development of resistance to Toxoplasma-gondii in mice. Infect Immun 1991 59 : 1614 1619.
22. Chen W, Frank ME, Jin W Wahl SM. TGF-β released by apoptotic T cells contributes to an immunosuppressive milieu. Immunity 2001 14 : 715 725.
23. Ronchetti A, Rovere P, Iezzi G, et al. Immunogenicity of apoptotic cells in vivo: role of antigen load, antigen-presenting cells, and cytokines. J Immunol 1999a 163 : 130 136.
24. Savill J. Apoptosis. Phagocytic docking without shocking. Nature 1998 392 : 442 443.
25. Menoret A, Patry Y, Burg C Le Pendu J. Co-segregation of tumor immunogenicity with expression of inducible but not constitutive Hsp70 in rat colon carcinomas. J Immunol 1995 155 : 740 747.
26. Stuart LM, Lucas M, Simpson C, Lamb J, Savill J Lacy-Hulbert A. Inhibitory effects of apoptotic cell ingestion upon endotoxin-driven myeloid dendritic cell maturation. J Immunol 2002 168 : 1627 1635.
27. Aliberti J, Valenzuela JG, Carruthers VB, et al. Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells. Nat Immunol 2003 4 : 485 490.
28. Yaovinsky F, Zhang D, Andersen JF, et al. TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science 2005 308 : 1626 1629.