Protective mucosal Th2 immune response against Toxoplasma gondii by murine mesenteric lymph node dendritic cells

Infection and Immunity

Volumn 71, Issue 9, 2003, Pages 5254-5265

  Dimier Poisson, Isabelle ^a,b   Aline, Fleur ^a   Mévélec, Marie Noëlle ^a   Beauvillain, Céline ^a   Buzoni Gatel, Dominique ^a   Bout, Daniel ^a  

^a CEMAGREF   (France)

^b UFR des Sciences Pharmaceutiques   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADOPTIVE TRANSFER; ANIMAL CELL; ANTIGEN RECOGNITION; ARTICLE; CELL PROTECTION; CYTOKINE RELEASE; DENDRITIC CELL; IMMUNE RESPONSE; IMMUNOGENICITY; INTESTINE EPITHELIUM; MESENTERY LYMPH NODE; MOUSE; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TH2 CELL; TOXOPLASMA GONDII; TOXOPLASMOSIS;

ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; CYTOKINES; DENDRITIC CELLS; FEMALE; HUMANS; IMMUNITY, MUCOSAL; IMMUNOGLOBULIN A, SECRETORY; IMMUNOGLOBULIN G; IMMUNOPHENOTYPING; INTESTINES; LYMPH NODES; LYMPHOCYTE ACTIVATION; MESENTERY; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; SPLEEN; TH1 CELLS; TH2 CELLS; TOXOPLASMA; TOXOPLASMOSIS, ANIMAL;

EID: 0042324189     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.71.9.5254-5265.2003     Document Type: Article

References (34)

1. Anjuere, F., P. Martin, I. Ferrero, M. L. Fraga, G. M. del Hoyo, N. Wright, and C. Ardavin. 1999. Definition of dendritic cell subpopulations present in the spleen, Peyer's patches, lymph nodes, and skin of the mouse. Blood 93:590-598.
2. Bourguin, I., M. Moser, D. Buzoni-Gatel, F. Tielemans, D. Bout, J. Urbain, and O. Leo. 1998. Murine dendritic cells pulsed in vitro with Toxoplasma gondii antigens induce protective immunity in vivo. Infect. Immun. 66:4867-4874.
3. Buzoni-Gatel, D., A. C. Lepage, I. H. Dimier-Poisson, D. T. Bout, and L. H. Kasper. 1997. Adoptive transfer of gut intraepithelial lymphocytes protects against murine infection with Toxoplasma gondii. J. Immunol. 158:5883-5889.
4. + T cells. Infect. Immun. 70:434-443.
5. Chang, C.-C., A. Wright, and J. Punnonen. 2000. Monocyte-derived CD1a+ and CD1a- dendritic cell subsets differ in their cytokine production profiles, susceptibilities to transfection, and capacities to direct Th cell differentiation. J. Immunol. 165:3584-3591.
6. Chardes, T., I. Bourguin, M. N. Mevelec, J. F. Dubremetz, and D. Bout. 1990. Antibody responses to Toxoplasma gondii in sera, intestinal secretions, and milk from orally infected mice and characterization of target antigens. Infect. Immun. 58:1240-1246.
7. Chardes, T., F. Velge-Roussel, P. Mevelec, M. N. Mevelec, D. Buzoni-Gatel, and D. Bout. 1993. Mucosal and systemic cellular immune responses induced by Toxoplasma gondii antigens in cyst orally infected mice. Immunology 78:421-429.
8. Chen, Y., J. Inobe, R. Marks, P. Gonnella, V. K. Kuchroo, and H. L. Weiner. 1995. Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature 376:177-180.
9. Cook, D. N., D. M. Prosser, R. Forster, J. Zhang, N. A. Kuklin, S. J. Abbondanzo, X. D. Niu, S. C. Chen, D. J. Manfra, M. T. Wiekowski, L. M. Sullivan, S. R. Smith, H. B. Greenberg, S. K. Narula, M. Lipp, and S. A. Lira. 2000. CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue. Immunity 12:495-503.
10. Daynes, R. A., B. A. Araneo, T. A. Dowell, K. Huang, and D. Dudley. 1990. Regulation of murine lymphokine production in vivo III. The lymphoid tissue microenvironment exerts regulatory influences over T helper cell function. J. Exp. Med. 171:979-996.
11. Everson, M. P., D. S. McDuffie, D. G. Lemak, W. J. Koopman, J. R. McGhee, and K. W. Beagley. 1996. Dendritic cells from different tissues induce production of different T cell cytokine profiles. J. Leukoc. Biol. 59:494-498.
12. Frenkel, J. 1988. Pathophysiology of toxoplasmosis. Parasitol. Today 4:273-278.
13. Gazzinelli, R. T., F. T. Hakim, S. Hieny, A. Cheever, and A. Sher. 1991. Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine. J. Immunol. 146:286-292.
14. Gazzinelli, R. T., E. Y. Denkers, and A. Sher. 1993. Host resistance to Toxoplasma gondii: model for studying the selective induction of cell-mediated immunity by intracellular parasites. Infect. Agents Dis. 2:139-149.
15. Inaba, K., M. Inaba, N. Romani, H. Aya, M. Deguchi, S. Ikehara, S. Muramatsu, and R. M. Steinman. 1992. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 176:1693-1702.
16. Iwasaki, A., and B. L. Kelsall. 1999. Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells. J. Exp. Med. 190:229-239.
17. Johnson, L. L., and P. C. Sayles. 1997. Interleukin-12, dendritic cells, and the initiation of host-protective mechanisms against Toxoplasma gondii. J. Exp. Med. 186:1799-1802.
18. Johnson, L. L., and P. C. Sayles. 2002. Deficient humoral responses underlie susceptibility to Toxoplasma gondii in CD4-deficient mice. Infect. Immun. 70:185-191.
19. Kang, H. J. S. Remington, and Y. Suzuki. 2000. Decreased resistance of B cell-deficient mice to infection with Toxoplasma gondii despite unimpaired expression of IFN-gamma, TNF-alpha, and inducible nitric oxide synthase. J. Immunol. 164:2629-2634.
20. Kjerrulf, M., D. Grdic, M. Kopf, and N. Lycke. 1998. Induction of gut mucosal immune responses: importance of genetic background and Th1/Th2 cross-regulation. Scand. J. Immunol. 47:401-407.
21. Kupiec-Weglinski, J. W., J. M. Austyn, and P. J. Morris. 1988. Migration patterns of dendritic cells in the mouse. Traffic from the blood, and T cell-dependent and -independent entry to lymphoid tissues. J. Exp. Med. 167:632-645.
22. Lafferty, K. J., A. Bootes, G. Dart, and D. W. Talmage. 1976. Effect of organ culture on the survival of thyroid allografts in mice. Transplantation 22:138-149.
23. Liesenfeld, O., J. Kosek, J. S. Remington, and Y. Suzuki. 1996. Association of CD4+ T cell-dependent, interferon-gamma-mediated necrosis of the small intestine with genetic susceptibility of mice to peroral infection with Toxoplasma gondii. J. Exp. Med. 184:597-607.
24. Morikawa, Y., M. Furotani, K. Kuribayashi, N. Matsuura, and K. Kakudo. 1992. The role of antigen-presenting cells in the regulation of delayed-type hypersensitivity. I. Spleen dendritic cells. Immunology 77:81-87.
25. Morikawa, Y., K. Tohya, H. Ishida, N. Matsuura, and K. Kakudo. 1995. Different migration patterns of antigen-presenting cells correlate with Th1/Th2-type responses in mice. Immunology 85:575-581.
26. Pugh, C. W., G. G. MacPherson, and H. W. Steer. 1983. Characterization of nonlymphoid cells derived from rat peripheral lymph. J. Exp. Med. 157:1758-1779.
27. Remington, J. S., R. McLeod, and G. Desmonts. 1995. Toxoplasmosis, p. 140. In J. S. Remington and J. O. Klein (ed.), Infectious diseases of the fetus and newborn infant, 4th ed. The W. B. Saunders Co., Philadelphia, Pa.
28. Sayles, P. C., G. W. Gibson, and L. L. Johnson. 2000. B cells are essential for vaccination-induced resistance to virulent Toxoplasma gondii. Infect. Immun. 68:1026-1033.
29. Sharma, S. D., J. Mullenax, F. G. Araujo, H. A. Erlich, and J. S. Remington. 1983. Western blot analysis of the antigens of Toxoplasma gondii recognized by human IgM and IgG antibodies. J. Immunol. 131:977-983.
30. Steinman, R. M., and M. C. Nussenzweig. 1980. Dendritic cells: features and functions. Immunol. Rev. 53:127-147.
31. Stumbles, P. A., J. A. Thomas, C. L. Pimm, P. T. Lee, T. J. Venaille, S. Proksch, and P. G. Holt. 1998. Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity. J. Exp. Med. 188:2019-2031.
32. Takahashi, H., Y. Nakagawa, K. Yokomuro, and J. A. Berzofsky. 1993. Induction of CD8+ cytotoxic T lymphocytes by immunization with syngeneic irradiated HIV-1 envelope derived peptide-pulsed dendritic cells. Int. Immunol. 5:849-857.
33. Toes, R. E., E. I. van der Voort, S. P. Schoenberger, J. W. Drijfhout, L. van Bloois, G. Storm, W. M. Kast, R. Offringa, and C. J. Melief. 2000. Enhancement of tumor outgrowth through CTL tolerization after peptide vaccination is avoided by peptide presentation on dendritic cells. J. Immunol. 160:4449-4456.
34. Yap, G., M. Pesin, and A. Sher. 2000. Cutting edge: IL-12 is required for the maintenance of IFN-gamma production in T cells mediating chronic resistance to the intracellular pathogen, Toxoplasma gondii. J. Immunol. 165:628-631.