In vitro experiments demonstrate that monocytes and dendritic cells are rendered apoptotic by extracorporeal photochemotherapy, but exhibit unaffected surviving and maturing capacity after 30 Gy gamma irradiation

Scandinavian Journal of Immunology

Volumn 68, Issue 6, 2008, Pages 645-651

  Rao, V ^a,b   Saunes, M ^c   Jorstad S ^c   Moen, T ^c  

^a Children's and Women's Health ^*  (Norway)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^c TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; METHOXSALEN;

APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DENDRITIC CELL; GAMMA IRRADIATION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IN VITRO STUDY; INTERMETHOD COMPARISON; LYMPHOCYTE; MONOCYTE; NORMAL HUMAN; PHOTOCHEMOTHERAPY; PRIORITY JOURNAL; PUVA; RADIATION DOSE;

ANTIGENS, CD14; APOPTOSIS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELLS, CULTURED; DENDRITIC CELLS; GAMMA RAYS; HUMANS; LECTINS, C-TYPE; LIPOPOLYSACCHARIDES; MANNOSE-BINDING LECTINS; MONOCYTES; PHOTOPHERESIS; RECEPTORS, CELL SURFACE;

EID: 55349091374     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2008.02179.x     Document Type: Article

References (40)

1. Yoo EK, Rook AH, Elenitsas R, Gasparro FP, Vowels BR. Apoptosis induction of ultraviolet light A and photochemotherapy in cutaneous T-cell Lymphoma: relevance to mechanism of therapeutic action. J.Invest Dermatol 1996 107 : 235 42.
2. Edelson R, Berger C, Gasparro F et al. Treatment of cutaneous T-cell lymphoma by extracorporeal photochemotherapy. Preliminary results. N.Engl.J.Med 1987 316 : 297 303.
3. Greinix HT, Volc-Platzer B, Kalhs P et al. Extracorporeal photochemotherapy in the treatment of severe steroid-refractory acute graft-versus-host disease: a pilot study. Blood 2000 96 : 2426 31.
4. Barr ML, Baker CJ, Schenkel FA et al. Prophylactic photopheresis and chronic rejection: effects on graft intimal hyperplasia in cardiac transplantation. Clin Transplant 2000 14 : 162 6.
5. Dall'Amico R, Murer L, Montini G et al. Successful treatment of recurrent rejection in renal transplant patients with photopheresis. J Am Soc Nephrol 1998 9 : 121 7.
6. Lehrer MS, Rook AH, Tomaszewski JE, DeNofrio D. Successful reversal of severe refractory cardiac allograft rejection by photopheresis. J Heart Lung Transplant 2001 20 : 1233 6.
7. Villanueva J, Bhorade SM, Robinson JA, Husain AN, Garrity ER Jr. Extracorporeal photopheresis for the treatment of lung allograft rejection. Ann Transplant 2000 5 : 44 7.
8. Faresjo MK, Ernerudh J, Berlin G, Garcia J, Ludvigsson J. The immunological effect of photopheresis in children with newly diagnosed type 1 diabetes. Pediatr Res 2005 58 : 459 66.
9. Knobler RM, French LE, Kim Y et al. A randomized, double-blind, placebo-controlled trial of photopheresis in systemic sclerosis. J Am Acad Dermatol 2006 54 : 793 9.
10. Enomoto DN, Schellekens PT, Yong SL, ten B, I Mekkes JR, Bos JD. Extracorporeal photochemotherapy (photopheresis) induces apoptosis in lymphocytes: a possible mechanism of action of PUVA therapy. Photochem Photobiol 1997 65 : 177 80.
11. Lamioni A, Parisi F, Isacchi G et al. The immunological effects of extracorporeal photopheresis unraveled: induction of tolerogenic dendritic cells in vitro and regulatory T cells in vivo. Transplantation 2005 79 : 846 50.
12. Tambur AR, Ortegel JW, Morales A, Klingemann H, Gebel HM, Tharp MD. Extracorporeal photopheresis induces lymphocyte but not monocyte apoptosis. Transplant Proc 2000 32 : 747 8.
13. Berger CL, Hanlon D, Kanada D, Girardi M, Edelson RL. Transimmunization, a novel approach for tumor immunotherapy. Transfus Apher Sci 2002 26 : 205 16.
14. Lim HW, Edelson RL. Photopheresis for the treatment of cutaneous T-cell lymphoma. Hematol Oncol Clin North Am 1995 9 : 1117 26.
15. Oliven A, Shechter Y. Extracorporeal photopheresis: a review. Blood Rev 2001 15 : 103 8.
16. Russo GG, Mullen C. Cutaneous and noncutaneous disorders treated with extracorporeal photopheresis. Int J Dermatol 2001 40 : 89 100.
17. Rook AH, Suchin KR, Kao DM et al. Photopheresis: clinical applications and mechanism of action. J Investig Dermatol Symp Proc 1999 4 : 85 90.
18. Berger CL, Xu AL, Hanlon D et al. Induction of human tumor-loaded dendritic cells. Int J Cancer 2001 91 : 438 47.
19. Merrick A, Errington F, Milward K et al. Immunosuppressive effects of radiation on human dendritic cells: reduced IL-12 production on activation and impairment of naive T-cell priming. Br J Cancer 2005 92 : 1450 8.
20. Zhou LJ, Tedder TF. CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells. Proc Natl Acad Sci USA 1996 93 : 2588 92.
21. Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 1994 179 : 1109 18.
22. Sallusto F, Cella M, Danieli C, Lanzavecchia A. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J Exp Med 1995 182 : 389 400.
23. Romani N, Reider D, Heuer M et al. Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability. J Immunol Methods 1996 196 : 137 51.
24. Reddy A, Sapp M, Feldman M, Subklewe M, Bhardwaj N. A monocyte conditioned medium is more effective than defined cytokines in mediating the terminal maturation of human dendritic cells. Blood 1997 90 : 3640 6.
25. Cochand L, Isler P, Songeon F, Nicod LP. Human lung dendritic cells have an immature phenotype with efficient mannose receptors. Am J Respir Cell Mol Biol 1999 21 : 547 54.
26. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998 392 : 245 52.
27. Banchereau J, Briere F, Caux C et al. Immunobiology of dendritic cells. Annu Rev Immunol 2000 18 : 767 811.
28. Zhou LJ, Tedder TF. Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. J Immunol 1995 154 : 3821 35.
29. Heng AE, Sauvezie B, Genestier L, Demeocq F, Dosgilbert A, Deteix P. PUVA apoptotic response in activated and resting human lymphocytes. Transfus Apher Sci 2003 28 : 43 50.
30. Bredberg A, Jonsson S, Lindblom A, Bjork P. Clinical-scale generation of strongly CD83-expressing dendritic cells using extracorporeal photopheresis. Photodermatol Photoimmunol Photomed 2007 23 : 113 9.
31. Legitimo A, Consolini R, Di SR, Bencivelli W, Mosca F. Psoralen and UVA light: an in vitro investigation of multiple immunological mechanisms underlying the immunosuppression induction in allograft rejection. Blood Cells Mol Dis 2002 29 : 24 34.
32. Maeda A, Schwarz A, Kernebeck K et al. Intravenous infusion of syngeneic apoptotic cells by photopheresis induces antigen-specific regulatory T cells. J Immunol 2005 174 : 5968 76.
33. Setterblad N, Garban F, Weigl R et al. Extracorporeal photophoresis increases sensitivity of monocytes from patients with graft-versus-host disease to HLA-DR-mediated cell death. Transfusion 2008 48 : 169 77.
34. Gerber A, Bohne M, Rasch J, Struy H, Ansorge S, Gollnick H. Investigation of annexin V binding to lymphocytes after extracorporeal photoimmunotherapy as an early marker of apoptosis. Dermatology 2000 201 : 111 7.
35. Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J Immunol Methods 1995 184 : 39 51.
36. Spisek R, Gasova Z, Bartunkova J. Maturation state of dendritic cells during the extracorporeal photopheresis and its relevance for the treatment of chronic graft-versus-host disease. Transfusion 2006 46 : 55 65.
37. Girardi M, Berger CL, Wilson LD et al. Transimmunization for cutaneous T cell lymphoma: a Phase I study. Leuk Lymphoma 2006 47 : 1495 503.
38. Rao V, Ryggen K, Aarhaug M, Dai H, Jorstad S, Moen T. Extracorporeal photochemotherapy in patients with cutaneous T-cell lymphoma: is clinical response predictable? J Eur Acad Dermatol Venereol 2006 20 : 1100 7.
39. Gaudernack G. Prospects for vaccine therapy for pancreatic cancer. Best Pract Res Clin Gastroenterol 2006 20 : 299 314.
40. Peritt D. Potential mechanisms of photopheresis in hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2006 12 : 7 12.