Motoneuronotrophic factor analog GM6 reduces infarct volume and behavioral deficits following transient ischemia in the mouse

Brain Research

Volumn 1238, Issue , 2008, Pages 143-153

  Yu, Jin ^a   Zhu, Hong ^a   Ko, Dorothy ^b   Kindy, Mark S ^a,c,d  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b Genervon Biopharmaceuticals   (United States)

^c RALPH H JOHNSON VA MEDICAL CENTER   (United States)

^d Neurological Testing Service Inc   (United States)

Author keywords

Middle cerebral artery occlusion; Mouse; Neuroprotection; Stroke; Trophic factor

Indexed keywords

GM 6; NEUROTROPHIN; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BLOOD BRAIN BARRIER; BRAIN INFARCTION; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG PENETRATION; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; TRANSIENT ISCHEMIC ATTACK;

ANIMALS; APOPTOSIS; BEHAVIOR, ANIMAL; BRAIN; ENZYME-LINKED IMMUNOSORBENT ASSAY; IN SITU NICK-END LABELING; INFLAMMATION; ISCHEMIC ATTACK, TRANSIENT; MICE; MICE, INBRED C57BL; NERVE GROWTH FACTORS; NEUROGENESIS; NEUROPROTECTIVE AGENTS; PEPTIDES;

MUS;

EID: 55349088207     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2008.08.053     Document Type: Article

References (61)

1. American Heart Association, Heart Disease and Stroke Statistics - 2006 Update, http://www.americanheart.org/downloadable/heart/ 1136308648540Statupdate2006.pdf.
2. Arumugam T.V., Selvaraj P.K., Woodruff T.M., and Mattson M.P. Targeting ischemic brain injury with intravenous immunoglobulin Expert. Opin. Ther. Targets 12 2008 19 29
3. Barde Y.A. What, if anything, is a neurotrophic factor? TINS 11 1988 343 346
4. Barde Y.A. Trophic factors and neuronal survival Neuron 2 1989 1525 1534
5. Borsello T., and Forloni G. JNK signalling: a possible target to prevent neurodegeneration Curr. Pharm. Des. 13 2007 1875 1886
6. Burek M.J., and Oppenheim R.W. Programmed cell death in the developing nervous system Brain Pathol. 6 1996 427 446
7. Buss R.R., and Oppenheim R.W. Role of programmed cell death in normal neuronal development and function Anat. Sci. Int. 79 2004 191 197
8. Chau, R.M.W., 2001. Polynucleotides encoding motoneuronotrophic factors. US Patent #6,309,877.
9. Chau, R.M.W., 2005. Methods and use of motoneuronotrophic factors. US Patent #6,841,531.
10. Chau, R.M.W., 2007. MNTF peptides and compositions and methods of use. US Patent #7,183,373.
11. Chau R.M.W., Wu X.Y., Zhao L.P., Ren F., and Jen J.S. Neuronotrophic factor Chin. J. Neuroanat. 6 1990 129 138
12. Chau R.M.W., Zhao L.P., and Jen L.S. The effect of a 30 kDa protein from tectal extract on cultured retinal ganglion cell Scient. Sin. B1 1991 50 53
13. Chau R.M.W., Zhao L.P., and Jen L.S. The effect of a 30 kDa protein from tectal extract on cultured retinal neuron Sci. China 34 1991 33 39
14. Chau R.M.W., Ren F., Huang W., and Jen L.S. Muscle neurotrophic factors specific for anterior horn motoneurons of rat spinal cord Recent Adv. Cell Mol. Biol. 5 1992 89 94
15. Chau, R.M.W., Ren, F., Liang, Z.H., 1993. Cloning of genes for muscle-derived motoneuronotrophic factor 1 (MNTF1) and its receptor by monoclonal antibody probes. Soc. Neurosci. 19, 252, #109.23.
16. Di X., and Huang W. Localization and morphometric study on motoneuronotrophic factor 1 and its receptor in developing chorionic villi of human placenta Acta Anat. Sin. 29 1998 86 89
17. Di X., Huang W.Q., and Sun L. Immunohistochemical localization of c-fos p53 protein and MNTF1 receptor in early human placental villi Acta Anat. Sin. 28 1997 404 406
18. Dubal D.B., Zhu H., Yu J., Rau S.W., Shughrue P.J., Merchenthaler I., Kindy M.S., and Wise P.M. Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury Proc. Natl. Acad. Sci. U. S. A. 98 2001 1952 1957
19. Ducruet A.F., Hassid B.G., Mack W.J., Sosunov S.A., Otten M.L., Fusco D.J., Hickman Z.L., Kim G.H., Komotar R.J., Mocco J., and Connolly E.S. C3a receptor modulation of granulocyte infiltration after murine focal cerebral ischemia is reperfusion dependent J. Cereb. Blood Flow Metab. 28 2008 1048 1058
20. Edgar D. Nerve growth factors and molecules of the extracellular matrix in neuronal development J. Cell Sci. (Suppl. 3) 1985 107 113
21. Ekshyyan O., and Aw T.Y. Apoptosis in acute and chronic neurological disorders Front Biosci. 9 2004 1567 1576
22. Ellsworth J.L., Garcia R., Yu J., and Kindy M.S. Fibroblast growth factor-18 reduced infarct volumes and behavioral deficits after transient occlusion of the middle cerebral artery in rats Stroke 34 2003 1507 1512
23. Ellsworth J.L., Garcia R., Yu J., and Kindy M.S. Time window of fibroblast growth factor-18-mediated neuroprotection after occlusion of the middle cerebral artery in rats J. Cereb. Blood Flow Metab. 24 2004 114 123
24. Gary D.S., Bruce-Keller A.J., Kindy M.S., and Mattson M.P. Ischemic and excitotoxic brain injury is enhanced in mice lacking the p55 tumor necrosis factor receptor J. Cereb. Blood Flow Metab. 18 1998 1283 1287
25. Grupper M., Eran A., and Shifrin A. Ischemic stroke, aortic dissection, and thrombolytic therapy-the importance of basic clinical skills J. Gen. Intern. Med. 22 2007 1370 1372
26. Hennigan A., O'Callaghan R.M., and Kelly A.M. Neurotrophins and their receptors: roles in plasticity, neurodegeneration and neuroprotection Biochem. Soc. Trans. 35 2007 424 427
27. Hollyday M., and Hamburger V. Reduction in naturally occurring motor neuron loss by enlargement of the periphery J. Comp. Neurol. 170 1976 311 320
28. Huang Z., Huang P.L., Ma J., Meng W., Ayata C., Fishman M.C., and Moskowitz M.A. Enlarged infarcts in endothelial nitric oxide synthase knockout mice are attenuated by nitro-l-arginine J. Cereb. Blood Flow Metab. 16 1996 981 987
29. Kahles T., Luedike P., Endres M., Galla H.J., Steinmetz H., Busse R., Neumann-Haefelin T., and Brandes R.P. NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke Stroke 38 2007 3000 3006
30. Kempermann G., Gast D., Kronenberg G., Yamaguchi M., and Gage F.H. Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice Development 130 2003 391 399
31. Khan M., Sekhon B., Jatana M., Giri S., Gilg A.G., Sekhon C., Singh I., and Singh A.K. Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke J. Neurosci. Res. 76 2004 519 527
32. Kindy M.S., Bhat A.N., and Bhat N.R. Transient ischemia stimulates glial fibrillary acid protein and vimentin gene expression in the gerbil neocortex, striatum and hippocampus Brain Res. Mol. Brain Res. 13 1992 199 206
33. Krieglstein K., Strelau J., Schober A., Sullivan A., and Unsicker K. TGF-β and the regulation of neuron survival and death J. Physiol. 96 2002 25 30
34. Kuno M. Target dependence of motoneuronal survival: the current status Neurosci. Res. 9 1990 155 172
35. Levi-Montalcini R. Developmental neurobiology and the natural history of nerve growth factor Annu. Rev. Neurosci. 5 1982 341 362
36. Liu J., Solway K., Messing R.O., and Sharp F.R. Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils J. Neurosci. 18 1998 7768 7778
37. Mattson M.P., Zhu H., Yu J., and Kindy M.S. Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis J. Neurosci. 20 2000 1358 1364
38. McManaman J.L., Crawford F.G., Stewart S.S., and Appel S.H. Purification of a skeletal muscle polypeptide which stimulates choline acetyltransferase activity in cultured spinal cord neurons J. Biol. Chem. 263 1988 5890 5897
39. McManaman J.L., Oppenheim R.W., Prevette D., and Marchetti D. Rescue of motoneuron from cell death by a purified skeletal muscle polypeptide: effects of the ChAT development factor, CDF Neuron 9 1990 155 172
40. Mennerick S., and Zorumski C.F. Neural activity and survival in the developing nervous system Mol. Neurobiol. 22 2000 41 54
41. O'Brien R.J., and Fischbach G.D. Modulation of embryonic chick motoneuron glutamate sensitivity by interneurons and agonists J. Neurosci. 6 1986 3290 3296
42. Oppenheim R.W. The neurotrophic theory and naturally occurring motoneuron death Trends Neurosci. 12 1989 252 255
43. Oppenheim R.W., and Haverkamp L.J. Neurotrophic interactions in the development of spinal cord motoneurons Ciba Found Symp. 138 1988 152 171
44. Petito C.K., Olarte J.P., Roberts B., Nowak T.S. Jr., and Pulsinelli W.A. Selective glial vulnerability following transient global ischemia in rat brain J. Neuropathol. Exp. Neurol. 57 1998 231 238
45. Rami A., Bechmann I., and Stehle J.H. Exploiting endogenous anti-apoptotic proteins for novel therapeutic strategies in cerebral ischemia Prog. Neurobiol. 85 2008 273 296
46. Rodríguez-Yáñez M., and Castillo J. Role of inflammatory markers in brain ischemia Curr. Opin. Neurol. 21 2008 353 357
47. Rothwell N.J., and Luheshi G.N. Brain TNF: damage limitation or damaged reputation? Nat. Med. 2 1996 746 747
48. Sendtner M., Pei G., Beck M., Schweizer U., and Wiese S. Developmental motoneuron cell death and neurotrophic factors Cell Tissue Res. 301 2000 71 84
49. Sivilia S., Giuliani A., Del Vecchio G., Giardino L., and Calza L. Age-dependent impairment of hippocampal neurogenesis in chronic cerebral hypoperfusion Neuropath. Appl. Neurobiol. 34 2008 52 61
50. Smith R.G., Vaca K., McManaman J., and Appel S.H. Selective effects of skeletal muscle extract fractions on motoneuron development in vitro J. Neurosci. 6 1986 439 447
51. Thoenen H., and Edgar D. Neurotrophic factors Science 229 1985 238 242
52. Varon S., Manthorpe M., Davis G.E., Williams L.R., and Skaper S.D. Growth factors Adv. Neurol. 47 1988 493 521
53. Wachs F.P., Winner B., Couillard-Despres S., Schiller T., Aigner R., Winkler J., Bogdahn U., and Aigner L. Transforming growth factor-beta1 is a negative modulator of adult neurogenesis J. Neuropathol. Exp. Neurol. 65 2006 358 370
54. Wang A.M., Chau R.M.W., Chow S.P., Zhang Z.Y., and Li Z.M. Effects of myogenic 22 and 35 kD neurotrophic factors on axonal regeneration in free peripheral autografts into rat spinal cord Chin. J. Spine Spinal Cord 5 1995 248 252
55. Wang Y., Jin K., and Greenberg D.A. Neurogenesis associated with endothelin-induced cortical infarction in the mouse Brain Res. 1167 2007 118 122
56. Wong C.H., and Crack P.J. Modulation of neuro-inflammation and vascular response by oxidative stress following cerebral ischemia-reperfusion injury Curr. Med. Chem. 15 2008 1 14
57. Young A.R., Ali C., Duretête A., and Vivien D. Neuroprotection and stroke: time for a compromise J. Neurochem. 103 2007 1302 1309
58. Zhou M.H., Wu X.Y., Ren F., Zhao L.P., Huang W.Q., Yang Z.Y., and Ren L.S. Effect of 22kD, 35 kD molecules from skeletal muscle extract on ant. Horn motoneuron of lumbar spine in rat Chin. Sci. Bull. 37 1992 1742 1745
59. Zhou M.H., Yu W.H., and Reb F. Changes in MNTF and its receptor in tongue muscle post-denervation of the hypoglossal nerve Acta Anat. Sin. 24 1993 391 395
60. Zhou M.H. Immunohistochemical localization of Motoneuronotrophic factor in fetal and neonatal rats Acta Anat. Sin. 25 1994 189 192
61. Zhou M.H., Wu X., and Chen S. Distribution of MNTF1 in spinal cord and limb muscles of mice with motoneuron disease Acta Acad. Med. Sin. 19 1997 171 178