The protozoan toxin climacostol inhibits growth and induces apoptosis of human tumor cell lines

Chemico-Biological Interactions

Volumn 176, Issue 2-3, 2008, Pages 151-164

  Buonanno, Federico ^a,b   Quassinti, Luana ^b   Bramucci, Massimo ^b   Amantini, Consuelo ^b   Lucciarini, Roberta ^b   Santoni, Giorgio ^b   Iio, Hideo ^c   Ortenzi, Claudio ^a,b  

^a UNIVERSITY OF MACERATA   (Italy)

^b UNIVERSITY OF CAMERINO   (Italy)

^c Osaka Prefecture University   (Japan)

Author keywords

Anticancer; Apoptosis; Climacostol; Cytotoxicity

Indexed keywords

ACETYLCYSTEINE; ANTINEOPLASTIC AGENT; CASPASE; CLIMACOSTOL; PHOSPHATIDYLSERINE; REACTIVE OXYGEN METABOLITE; TOXIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL STRAIN HL 60; CELL VIABILITY; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DRUG SYNTHESIS; ENZYME ACTIVATION; HUMAN; HUMAN CELL;

ACETYLCYSTEINE; APOPTOSIS; CASPASE 3; CASPASE 8; CELL PROLIFERATION; CELL SURVIVAL; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; NEOPLASMS; PHOSPHATIDYLSERINES; REACTIVE OXYGEN SPECIES; RESORCINOLS; TIME FACTORS; TUMOR CELLS, CULTURED;

CLIMACOSTOMUM VIRENS; MYXOZOA; PROTOZOA;

EID: 55249117932     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2008.07.007     Document Type: Article

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